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Nathan Goodyear

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mecha... - 0 views

www.ncbi.nlm.nih.gov/...PMC5592784

Chemotherapy metastasis cancer TMEMs 'tumor microenvironment of metastasis' "chemotherapy metastasis"

shared by Nathan Goodyear on 22 Jan 19 - No Cached
  • Nathan Goodyear on 22 Jan 19
     
    Study looked at tumor microenvironment of metastasis structures (TMEMs) involved in metastasis. It has also been shown that taxane-based chemotherapies promote tumor regrowth by inducing angiogenesis. In this study, the tumor growth was slowed with taxanes chemotherapies, but it increased TMEMs and thus metastatic potential.
Nathan Goodyear

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mecha... - 0 views

stm.sciencemag.org/...eaan0026

chemotherapy TMEM tumor microenvironment of metastasis metastasis cancer

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • We found about a twofold increase in circulating tumor cells (CTCs) (P < 0.05) after paclitaxel treatment in all experimental models examined
  • We found an increase in both the metastatic incidence (at least one micrometastatic focus of more than five tumor cells) (Fig. 3I) and the number of cancer cell micrometastases in the lungs of paclitaxel-treated mice
  • in early-stage breast cancers, chemotherapy increases vascular permeability at TMEM sites, which is accompanied by increased cancer cell dissemination.
  • ...1 more annotation...
  • significant ~1.3-fold (P = 0.027) increase in the number of CTCs
  • Nathan Goodyear on 11 Jul 17
     
    New study suggests chemotherapy may increase metastasis  via increase in TMEM.  I wonder if this increases recurrence as well.  Could the very corner stone of Cancer therapy actually increase metastatic risk potential?
Nathan Goodyear

Signatures of breast cancer metastasis at a glance - 1 views

www.ncbi.nlm.nih.gov/...PMC4893654

tumor microenvironment of metastasis TMEM cancer metastasis chemotherapy

shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Nathan Goodyear on 13 Apr 20
     
    To be read
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