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Nathan Goodyear

T3 increases mitochondrial ATP production in oxidative muscle despite increased express... - 0 views

ajpendo.physiology.org/...E761.full.pdf

T3 hypothyroid hypothyroidism Cancer

shared by Nathan Goodyear on 28 Jun 13 - No Cached
  • Nathan Goodyear on 28 Jun 13
     
    T3 increases mitochondrial oxidative phosphorylation. This has huge impacts on which hypothyroidism is currently managed (only evaluate TSH and T4) and disease implication. We know that decoupling of oxidative phosporylation and a shift to glycolysis and glutaminolysis (substrate-level phosphorylation) results in genomic mutability and cancer, then a low T3 has implications in cancer prevention
Nathan Goodyear

T3 increases mitochondrial ATP production in oxidative muscle despite increased express... - 0 views

ajpendo.physiology.org/...E761.long

T3 hypothyroid hypothyroidism cancer oxidative phosphorylation mitochondria thyroid hormone hormones atp

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    This study finds that T3 increases enzymes in the oxidative phosphorylation pathways and not in the glycolytic pathways in mitochondria.  This has enormous health implications, especially in cancer.  This also casts doubt on the current traditional medical dogma of hypothyroid evaluation and management which gives no regard to T3 in testing or therapy.
Nathan Goodyear

Hypothyroidism and hyponatraemia: diagnostic relevance of ADH measurement - 0 views

www.endocrine-abstracts.org/...ea0015p364.htm

hypothyroidism hyponatraemia

shared by Nathan Goodyear on 15 Aug 16 - No Cached
  • Nathan Goodyear on 15 Aug 16
     
    hypothyroidism and hyponatraemia.  Interesting point that the patient was started on T4/T3 therapy.
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

jcem.endojournals.org/...1172.full

free T3 fT3 heart cardiac MI myocardial infarction hypothyroidism hypothyroid CHF congestive heart failure hormone hormones thyroid

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
Nathan Goodyear

The Influence of Age on the Relationship between Subclinical Hypothyroidism and Ischemi... - 0 views

jcem.endojournals.org/...2998.long

subclinical hypothyroidism ischemic heart disease heart heart disease thyroid disease thyroid

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    subclinical hypothyroidism is associated with an increase in ischemic heart disease in those <65.
Nathan Goodyear

Thyroid hormone and heart failure. [Curr Heart Fail Rep. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16914103

hypothyroidism hypothyroid low T3 heart failure thyroid hormone

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    Hypothyroidism is found to be associated with low T3, reduced heart contractility, and poor prognosis in heart failure
Nathan Goodyear

Arch Intern Med -- Abstract: Subclinical Hypothyroidism and the Risk of Heart Failure, ... - 0 views

archinte.ama-assn.org/...2460

subclinical hypothyroidism heart failure CHF

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    subclinical hypothyroidism associated with increased risk of heart failure
Nathan Goodyear

Brazilian Journal of Medical and Biological Research - Is the infertility in hypothyroi... - 0 views

www.scielo.br/scielo.php

functional hypothyroidism prolactin elevated gonadotropins infertility LH FSH

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    functional hypothyroidism associated with elevated prolactin levels and thus gonadotropin dysfunction and infertility
Nathan Goodyear

Risk of Hypothyroidism following Hemithyroidectomy: Systematic Review and Meta-Analysis... - 0 views

jcem.endojournals.org/...2243.abstract

hypothyroidism thyroidectomy

shared by Nathan Goodyear on 01 Aug 12 - No Cached
  • Nathan Goodyear on 01 Aug 12
     
    hypothyroidism is a side effect of partial thyroidectomy in about 20% of individuals.
Nathan Goodyear

ACTH-secreting pituitary microadenomas... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22587880

saliva salivary hormone hormones cortisol microadenomas hypothyroidism hypothyroid ACTH

shared by Nathan Goodyear on 26 Sep 12 - No Cached
  • Nathan Goodyear on 26 Sep 12
     
    Individuals with ACTH secreting microadenomas have a higher incidence of hypothyroidism and should be evaluated. This only makes physiologic sense, knowing the impact on 5'deiodinase, and TSH production. Also of importance, is the methodology of cortisol evaluation.  They used salivary cortisol levels to follow.  This study was conducted at John Hopkins school of Medicine, Division of Endocrinology.  Some how others here in Louisiana have missed this (Namely LSBME and BCBS).
Nathan Goodyear

Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Car... - 0 views

press.endocrine.org/...jc.2013-3591

subclinical hypothyroidism weight elderly cardiovascular health

shared by Nathan Goodyear on 16 Apr 14 - No Cached
  • Nathan Goodyear on 16 Apr 14
     
    Study found no significant effect of subclinical hypothyroidism on weight in the elderly.  However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Nathan Goodyear

Serum TSH, T4, and Thyroid Antibodies in the United States Population (1988 to 1994): N... - 0 views

press.endocrine.org/...jcem.87.2.8182

hypothyroid hypothyroidism thyroid TSH hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    This article finds the mean TSH level in the "healthy" population to be 1.5.  Calls into question any level above that with symptoms of hypothyroid.  Full, adequate thyroid including free T3 and rT3 must be done.
Nathan Goodyear

A rare case of amiodarone-induced hypothyroidis... [Int J Angiol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22942634

CVD cardiovascular disease cardiovascular disease prescription medications prescriptions hypothyroid hypothyroidism heart

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Very interesting case study of amiodarone induced hypothyroidism that resulted in pericardial effusion and cardiac tamponade.
Nathan Goodyear

Effects of thyroxine as compared with thyroxine pl... [N Engl J Med. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9971866

T3 T4 hypothyroidism armour thyroid USP

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • n patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function;
  • Nathan Goodyear on 19 Nov 10
     
    Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Nathan Goodyear

Hypothyroidism (Feb/March 2007) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...hypothyroid0207.htm

Armour thyroid treatment Hypothyroid synthroid USP hypothyroidism

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Great discussion of Thyroid therapy
Nathan Goodyear

Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and durin... - 0 views

www.clinchem.org/...1738

homocysteine hypothyroid hypothryoidism

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    hypothyroid patients have higher homocysteine levels than hyperthyroid patients; Elevated homocysteine is predictive of cardiovascular disease
Nathan Goodyear

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in... - 0 views

endo.endojournals.org/...2490

hypothyroid hypothyroidism T4 T3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Combined replacement therapy with T4 and T3 (in proportions similar to those secreted by the normal rat thyroid) completely restored euthyroidism in thyroidectomized rats at much lower doses of T4 than those needed to normalize T3 in most tissues when T4 alone was used
  • Nathan Goodyear on 08 Mar 11
     
    combined T4/T3 therapy the best approach in hypothyroidism
Nathan Goodyear

Replacement therapy for hypothyroidism with thyrox... [J Clin Invest. 1995] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...8675653

hypothyroidism replacement therapy T4 T3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • No single dose of T4 was able to restore normal plasma thyrotropin, T4 and T3, as well as T4 and T3 in all tissues, or at least to restore T3 simultaneously in plasma and all tissues. Moreover, in most tissues, the dose of T4 needed to ensure normal T3 levels resulted in supraphysiological T4 concentrations.
  • Nathan Goodyear on 08 Mar 11
     
    replacement therapy for hypothyroidism must include both T4 and T3
Nathan Goodyear

Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid ... - 0 views

onlinelibrary.wiley.com/...abstract

thyroid hypothyroid hypothyroidism leptin obesity overweight

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The data are consistent with the hypothesis that leptin and the pituitary–thyroid axis interact in the euthyroid state, and that hypothyroidism reversibly increases leptin concentrations
  • Nathan Goodyear on 08 Mar 11
     
    thyroid and leptin interact to control weight
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

jcem.endojournals.org/...6403

hormone thyroid concentrations rT3 reverse T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
  • Nathan Goodyear on 08 Mar 11
     
    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
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