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Nathan Goodyear

Effect of oral administration of testosterone on brachial arterial vasoreactivity in me... - 0 views

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    physiologic replacement of testosterone shown to increase NO synthesis, increased vasorelaxation, and reduced CVD symptoms, like hypertension.
Nathan Goodyear

EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lip... - 0 views

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    This study found that the elimination of hight dose vitamin C in EDTA chelation removed the pro oxidant effect. This provided an antioxidant effect only from EDTA chelation, which is beneficial in the oxidative damage diseases like CVD and Diabetes
Nathan Goodyear

Short-term changes in serum sex steroid levels and cardiac function in healthy young men - 0 views

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    High aromatase activity in men, as a result of abdominal fat associated with increased estrogen production and lowered Testosterone.  The result is increased CVD.  It's a man boob nation.
Nathan Goodyear

Co-occurrence of Cardiovascular and Prothrombotic Risk Facto... : Obstetrics & Gynecology - 0 views

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    preeclampsia should be a history marker that reveals increased cardiovascular disease (CVD).  
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
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  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
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    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

PLOS Medicine: Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Diseas... - 0 views

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    As ED is a cardiovascular problem, it is no surprise that those with ED have an increase in CVD.
Nathan Goodyear

Risk Factors Associated With Cardiovascular Events During Testosterone Administration i... - 0 views

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    This study proves the problems rampant in science today.  This study looked at older men with mobility limitations: safe to say, not optimal health.  They give 10 grams of testosterone daily to these men.  Physiologic doses are 5-10 mg.  And they are surprise that there is an increase in side effects, here in this study CVD.  They did look at cytokines, I'll give them that; but they did not look at aromatase activity and E2, E1 levels which have been shown to be the driving forces behind these inflammatory cytokines in men.  Testosterone has in fact been shown to downregulate these inflammatory cytokines.  Poor study.  No conclusion can be taken from this study.
Nathan Goodyear

Autonomic function and prognosis - 0 views

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    decreased heart rate variability associated with increased CVD and mortality
Nathan Goodyear

Neural regulation of the immune system modulates hypertension-induced target-organ damage - 0 views

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    cool read:  the future of CVD treatment.  The link between neuroimmunology and cardiovascular disease.
Nathan Goodyear

BioPsychoSocial Medicine | Full text | Effects of antidepressant treatment on heart rat... - 0 views

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    antidepressants shown to reduce heart rate variability (HRV) and an increased heart rate (HR), both of which increase cardiovascular disease (CVD).
Nathan Goodyear

http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf - 0 views

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    This is the unified paper theory of CVD and vitamin C as published by Pauling and Rath.  Vitamin C deficiency results in a decrease in the integrity and stability of the vascular wall.  Chronic deficiency results in in an increase in and accumulation of Lp(a) which leads to atherosclerotic plaques.
Nathan Goodyear

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and ... - 0 views

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    study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality.  Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
Nathan Goodyear

Multivitamin Use and the Risk of Cardiovascular Disease in Men. - PubMed - NCBI - 0 views

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    multivitamins associated with a decreased risk of major CVD events in 20 prospective study.  This is likely a component of a healthy lifestyle, but still shows that MVA use does have positive effects over all long duration.
Nathan Goodyear

Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type ... - 0 views

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    proinsulin is a good biomarker to assess insulin resistance in people with diabetes.  Proinsulin levels are associated with atherosclerosis and CVD.
Nathan Goodyear

Muscular strength in male adolescents and premature death: cohort study of one million ... - 0 views

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    low muscle strength associated with increased risk of early mortality and CVD in men.
Nathan Goodyear

Low serum testosterone, arterial stiffness and mortality in male haemodialysis patients - 0 views

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    low testosterone increases CVD and all-cause mortality in me.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease -- Traish et al. ... - 0 views

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    low testosterone is risk factor for CVD in men.  Of course, normalization of testosterone should be employed and followed in those men that have low T.
Nathan Goodyear

Testosterone Making an Entry Into the Cardiometabolic World - 0 views

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    low Testosterone associated with increased CVD and death.
Nathan Goodyear

Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Ca... - 0 views

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    low Testosterone found to be inversely correlated to an increase in CVD and mortality.
Nathan Goodyear

Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients - 0 views

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    low Testosterone associated with increased CVD in male hemodialysis patients
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