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England To Reopen Temporary Field Hospitals For Inpatients - 0 views

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    England is set to reopen temporary field hospitals to contain a possible overspill of inpatients due to a surge in coronavirus cases, the national health service said Thursday. Fuelled by the highly contagious Omicron variant, daily cases have ballooned, standing at more than 183,000 on Wednesday. NHS England said it would start building the structures in the grounds of eight hospitals in cities including London, Bristol and Leeds from this week, with each designed to house around 100 extra patients. "Given the high level of Covid-19 infections and increasing hospital admissions, the NHS is now on a war footing," National medical director Stephen Powis said. The extra beds are designed for patients who are recovering from illnesses, including those who no longer have Covid, to free up space and staff to treat large numbers of virus cases.
Nathan Goodyear

Hypercalcemia of malignancy and new treatment options - 0 views

  • Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
  • ectopic secretion of parathyroid hormone (PTH) has been implicated
  • Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
  • ...22 more annotations...
  • Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
  • 20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
  • Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
  • In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
  • In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
  • Macrophage inflammation protein 1-alpha (MIP 1-alpha)
  • hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
  • 1% of cases
  • increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
  • 1-α-hydroxylase in the kidney, a process regulated by PTH
  • in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
  • this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
  • Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
  • primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
  • an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
  • Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
  • Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
  • mildly symptomatic disease
  • marked symptoms
  • hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
  • denosumab
  • Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
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    hypercalcemia in cancer and treatments.
arunaraayala

Justin Bieber and Usher Cleared "Somebody to Love" Case| Locality News - 0 views

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    Pop sensation Justin Bieber and Usher within the clear when decide laid-off a replica case filed against them over the song 'Somebody to love.'
Nathan Goodyear

Cardiovascular Diabetology | Full text | Improvement of the diabetic foot upon testoste... - 0 views

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    Case report of 3 cases finds improvement in diabetic foot complications, including neuropathy, in men treated with Testosterone.  This makes sense as the Testosterone will improve insulin function, improve HgbA1c and reduce inflammation in these men.
Nathan Goodyear

Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People ... - 0 views

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    Case study of 3 patients with Pancreatic cancer treated with IV alpha lipoic acid and LDN therapy.  This is a f/u to a patient treated and still living--case study published in '06.  Only, the abstract is currently available to the general public.  
Nathan Goodyear

Celiac Disease Presenting as Autism - 0 views

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    This case study shows the link between gastrointestinal inflammation and the brain. This case is of a child diagnosed with autism that recovered once a gluten free diet was instituted.
Nathan Goodyear

How a charity oversells mammography | BMJ - 1 views

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    This article reveals how data is massaged to promote a viewpoint. In this case mammograms.  Don't let your passions get the best of you, objectively review the data.  Scientists are not doing that these days. Mammograms do help and are needed in the screening, however, mammograms do cause harm and help to promote the same disease it seeks to detect early.  This is in some cases. Also, remember, mammograms are early detection, not prevention.
Nathan Goodyear

The Relationships Between Testosterone, Body Composition, and Insulin Resistance - 0 views

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    case study that showed removal of testosterone secreting adrenal tumor worsened insulin function and contributed to weight gain 9 months post surgery.  This is a case study and far from conclusive.
Nathan Goodyear

Harriet Lane Handbook: Progesterone regulates the phosphorylation of protein phosphatas... - 0 views

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    rat model finds that progesterone effects internal cell enzyme activity.  In this case, progesterone increased PP2A in the cerebellum and in the hyippocampus.  Interesting, that E2 priming decreased the effects on the hippocampus, but not the cerebellum.  This reveals a biochemical link between sex hormones, progesterone in this case, and the brain.  Studies have shown progesterone to be neuroprotective in TBI.  This may be one mechanism.
Nathan Goodyear

Dramatic improvement in sexual function induced by... [J Sex Med. 2012] - PubMed - NCBI - 0 views

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    limited study as it is a case study of 1.  However, there was improvement with libido, erection, and orgasm in this case study of 1 with intranasal oxytocin.
Nathan Goodyear

Approach To A Patient With Elevated Serum Alkaline Phosphatase - 0 views

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    case review of patient with elevated alkaline phosphatase. This case study includes a nice review of bile formation/function.
Nathan Goodyear

Vitamin D for Cancer Prevention: Global Perspective - 0 views

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    Only abstract available here.  The authors of the this epidemiologic article estimate that 58,000 cases of breast cancer and 49,000 cases of colorectal cancer can be prevented annually by raising levels to 40-60.  The study also points to a new cancer model that Vitamin D has a positive effect at each step.  The acronym is DINOMIT and this stands for disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition.
wheelchairindia9

Chair For Cerebral Palsy Child - 0 views

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    Cerebral palsy (CP) is a group of conditions caused by medical abnormalities in the development of a fetus or the early life of a child. These lead to damage or delayed development in the brain. The disorder is permanent and, though it does not worsen with age, the level of functionality of a person with cerebral palsy varies widely: in some cases, effects may be very minor, while in others, movement is impaired to the extent that a wheelchair is required. Common complications associated with CP vary by the type of CP disorder but can include vision problems, seizures, learning disabilities, and issues speaking, writing, and performing other tasks. Cerebral palsy causes problems with muscle tone, movement, balance and/or coordination. Symptoms and effects range from mild to severe. In some infants, problems are evident soon after birth. In others, diagnosis comes in later infancy or toddlerhood. Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg Folding action. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cerebral Palsy Wheelchair Recline system: Recline system provides kids with the most comfortable resting environment. It also allows stretching abdomin
Nathan Goodyear

Cases Journal | Full text | Sudden elevation of liver enzymes in a 64-year-old patient:... - 0 views

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    case study of elevated liver enzymes induced by antibiotics.
Nathan Goodyear

Review of high-dose intravenous vitami... [Asia Pac J Clin Oncol. 2014] - PubMed - NCBI - 0 views

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    Study reviews the studies of IV vitamin C and cancer.  The authors discuss the mechanism of action of the high dose vitamin C.  The authors are correct in their conclusion that a large body of evidence is lacking and that the majority are case study.  However, to even discount these in the face of the safety and the reduction in side effects associated with chemotherapy by IV vitamin C would be unacceptable. To delay recommendation due to a full lack of understanding would be unacceptable as well.   No deaths have been reported due to IV vitamin C.  Contrast this with chemotherapy.  However, case studies have pointed to IV vitamin C as a positive tool to attach cancer.  
Nathan Goodyear

Acute Hepatitis Treated with High Doses of Vitamin C - 0 views

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    Old case study of IV vitamin C, not high dose, used to treat acute case of hepatitis C.
Nathan Goodyear

High dose intravenous vitamin c and metastatic pancreatic cancer: Two cases - 0 views

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    2 case studies of high dose vitamin C in pancreatic cancer with good results.  The important thing here is the imaging and biomarkers were initiated and followed.  Progressive cancers, like pancreatic cancer, require more frequent dosing of IVC.
Nathan Goodyear

Tips for writing a case report for the novice author - 0 views

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    Case study design
Nathan Goodyear

Guidelines to the writing of case studies - 0 views

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    Good read on creating a case study.
Nathan Goodyear

Cureus | Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet,... - 1 views

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    Asking questions that challenge dogma is difficult.  This individual case study just does that.  Case study finds that ketogenic diet, hyperthermic therapy, and hyperbaric oxygen reduce the side effects of chemo, improved quality of life, and at the time of the publication, remission of disease.
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