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Nathan Goodyear

Cureus | Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet,... - 1 views

www.cureus.com/...-triple-negative-breast-cancer

ketogenic diet hbot hyperbaric oxygen hyperbaric therapy diet nutrition cancer hyperthermic therapy chemotherapy

shared by Nathan Goodyear on 09 Jul 17 - No Cached
  • Nathan Goodyear on 09 Jul 17
     
    Asking questions that challenge dogma is difficult.  This individual case study just does that.  Case study finds that ketogenic diet, hyperthermic therapy, and hyperbaric oxygen reduce the side effects of chemo, improved quality of life, and at the time of the publication, remission of disease.
Nathan Goodyear

Hyperthermia in combined treatment of cancer. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12147435

hyperthermia hyperthermic therapy cancer chemotherapy

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • Nathan Goodyear on 30 Aug 18
     
    Hyperthermic therapy useful as adjunctive therapy as adjunct to radiotherapy and chemotherapy.
Nathan Goodyear

Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally ... - 0 views

ascopubs.org/...JCO.1990.8.11.1818

hyperthermia hyperthermic therapy cancer chemotherapy

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • Nathan Goodyear on 30 Aug 18
     
    Hyperthermic therapy augments chemotherapy for some with advanced sarcomas.  Systemic temperature at 37.4 C in this study.
Nathan Goodyear

Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Amo... - 0 views

jamanetwork.com/...2672386

hyperthermic therapy hyperthermia cancer chemotherapy

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • Heat exposure (40 °C to 43 °C) of cancer cells in preclinical studies, and hyperthermia regionally applied to patients in early randomized clinical studies, have shown synergistic activity with ionizing radiation and chemotherapy
  • For the combination of hyperthermia with chemotherapy, the study group at Munich7 was the first to demonstrate the safety and efficacy of regional hyperthermia (RHT) in patients with high-risk sarcoma.
  • Nathan Goodyear on 30 Aug 18
     
    hyperthermia therapy augments chemo therapy.
Nathan Goodyear

Therapeutic hyperthermia: The old, the new, and the upcoming - Critical Reviews in Onco... - 1 views

www.croh-online.com/...fulltext

hyperthermia hyperthermic therapy cancer oncology

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • not well understood, but it is felt to be a combination of both heat-induced necrosis and of protein inactivation (e.g., repair enzymes) as opposed to DNA damage
  • alterations in tumor cytoskeletal and membrane structures, which disrupt cell motility and intracellular signal transduction
  • A common explanation for HT-enhancement of RT and CT involves inhibition of homologous recombination repair of double-strand DNA breaks, preventing cells from repairing sub-lethal damage
  • ...15 more annotations...
  • it does appear to inhibit rejoining of RT-induced DNA breaks more than is commonly observed after RT alone
  • HT damages cells and enhances RT and CT sensitivity as a function of both temperature and duration of treatment
  • as temperature or duration increase, the rate of cell killing also increases
  • At temperatures above 42 °C, tumor vasculature is damaged, resulting in decreased blood flow
  • Cancer cells are particularly vulnerable to heating; in vivo studies have shown that temperatures in the range of 40–44 °C cause more selective damage to tumor cells
  • cancerous blood vessels are chaotic, leaky, and inefficient
  • selective cytotoxic effect on tumor cells include inhibition of key cancer cell-signaling pathways such as AKT, inducing apoptosis, suppression of cancer stem cell proliferation, and others
  • increase in immunological attacks against tumors after HT, which were believed to be achieved through activation of HSPs and subsequent modulation of the innate and adaptive immune responses against tumor cells
  • HT does lead to activation of the immune system and HSP-induced cell death through modification of the tumor cell surface
  • These HSPs and tumor antigens are taken up by dendritic cells and macrophages and go on to induce specific anti-tumor immunity
  • In vivo studies demonstrate HT-enhancement of NK cell activity, and HT has been shown to increase neutrophilic granulocytes with anti-tumor activity
  • it has become increasingly clear that HT results in immune stimulation, through both direct heat-mediated cell killing as well as innate and adaptive immune system modulation
  • The term hyperthermia is used in this review to refer to heating within the clinically accepted range of 40–45 °C
  • temperatures above 42.5–43 °C the exposure time can be halved with each 1 °C increase while maintaining equivalent cell killing
  • gradual heating at 43 °C for 1 h worked through an apoptotic pathway
  • Nathan Goodyear on 30 Aug 18
     
    Comprehensive review of hyperthemic therapy.
Nathan Goodyear

Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemot... - 2 views

jcmtjournal.com/...2272

hyperthermic therapy Hyperthermia Cancer

shared by Nathan Goodyear on 18 Dec 18 - No Cached
  • Nathan Goodyear on 18 Dec 18
     
    Nice review of the interactions of hyperthermia and the immune system in cancer.
Nathan Goodyear

https://www.researchgate.net/publication/21124247_Effect_of_carboplatin_combined_with_w... - 0 views

www.researchgate.net/...ormal_tissue_and_tumor_in_rats

Hyperthermia hyperthermic therapy Chemotherapy Cancer

shared by Nathan Goodyear on 18 Dec 18 - No Cached
  • Nathan Goodyear on 18 Dec 18
     
    Older study showed that hyperthermia enhanced cytotoxic activities of carboplatin and cisplatin.
Nathan Goodyear

Temperature Matters! And Why It Should Matter to Tumor Immunologists | Cancer Immunolog... - 1 views

cancerimmunolres.aacrjournals.org/...210.full

hyperthermic therapy hyperthermia cancer

shared by Nathan Goodyear on 30 Nov 18 - No Cached
  • Nathan Goodyear on 30 Nov 18
     
    Hyperthermia and the immune system
Nathan Goodyear

Hyperthermia and Chemotherapy - Holland-Frei Cancer Medicine - NCBI Bookshelf - 0 views

www.ncbi.nlm.nih.gov/...NBK13550

Hyperthermia Cancer Chemotherapy hyperthermic therapy

shared by Nathan Goodyear on 18 Dec 18 - No Cached
  • Nathan Goodyear on 18 Dec 18
     
    Brief review from book on severe hyperthermia and chemotherapy: The mechanisms that underlie the synergy may include (1) increased cellular uptake of drug, (2) increased oxygen radical production, and (3) increased DNA damage and inhibition of repair; potential use of HT with many drugs is its ability to reverse, at least partially, drug resistance
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