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Nathan Goodyear

Low-dose metronomic chemotherapy as an efficient treatment option in metastatic breast ... - 0 views

link.springer.com/...s10549-020-05711-5

MTD metastatic LDMC breast low-dose chemotherapy low-dose metronomic chemotherapy cancer) maximum tolerated chemotherapy

shared by Nathan Goodyear on 23 Feb 23 - No Cached
  • Nathan Goodyear on 23 Feb 23
     
    LDMC equal to out performing MTD in metastatic breast cancer.
Nathan Goodyear

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SA... - 0 views

www.ncbi.nlm.nih.gov/...PMC10222767

spike protein spike proteins IgG4 COVID19 COVID-19 COVID vaccination SARS-CoV-2

shared by Nathan Goodyear on 01 Jun 23 - No Cached
  • These mRNA vaccines represented a new type of vaccine that comprises synthetic mRNA molecules that contain the coding sequence necessary to build the SARS-CoV-2 Spike protein, which is encased in the lipid nanoparticles (LNPs) to allow for the delivery of mRNA to cells.
  • proteins are synthesized within the host cells
  • they can induce significant neutralizing anti-spike IgG and IgA response
  • ...3 more annotations...
  • Lethal COVID-19 cases have been linked to higher levels of IgG4 antibodies
  • mRNA vaccines trigger their synthesis
  • provide the scientific rationale suggesting that repeated vaccination with mRNA vaccines could generate an immune tolerance mechanism, thereby favoring unopposed SARS-CoV-2 replication.
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