Skip to main content

Home/ Dr. Goodyear/ Group items tagged (IJ)

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Aerobic fitness in late adolescence and the risk of early death: a prospective cohort s... - 0 views

ije.oxfordjournals.org/...ije.dyv321

exercise aerobic exercise fitness obesity

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    study finds death rates of obese, physically active individuals exceeds that of normal weight individuals that don't exercise.
Nathan Goodyear

Cytokines in the Progression of Pancreatic β-Cell Dysfunction - 0 views

www.hindawi.com/...515136

inflammation cytokines inflammatory pancreas DM diabetes type II diabetes metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    inflammatory cytokines lead to progressive pancreatic Beta islet cells dysfunction and resultant diabetes.
Nathan Goodyear

Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Ca... - 0 views

www.hindawi.com/...6437585

low T low Testosterone Testosterone SHBG hormones male hormones

shared by Nathan Goodyear on 30 Nov 16 - No Cached
  • Nathan Goodyear on 30 Nov 16
     
    SHBG plays an important role in Testosterone's cellular effect. Every man should have SHBG checked with Testosterone
ind swift

Gynecology Drugs| Pharmaceutical Formulations Development | Indian Drug Manufacturers - 1 views

www.indswiftltd.com/gyno_swift_division.php

DISTONE (IJ) 1X24

shared by ind swift on 14 Aug 12 - No Cached
ind swift liked it
  • ind swift on 14 Aug 12
     
    4 ANAPROCT CAP Each Capsule Contains: Neem (Azadirachta Indica) 25 Mg Suran (Amorphophallus Companulatus) 25 Mg Yashtimadhu (Glycirrhiza Glabra) 25 Mg Haritaki (Terminalia Chebula) 25 Mg Kumarighansatva (Aloe Vera) 50 Mg Mukta Shukti Bhasma(Pearl Oyster) 75 Mg Arishtak (Sapindus Trifoliatus) 75 Mg Saphatika Bhasma (Potash Alum) 100 Mg Daruhaldi Ghansatva(Ext.Berberis Aristata)100 Mg Capsule Anit-Haemorroidal Haemostat 5 ANAPROCT OINTMENT Lidocaine U.S.P.
Nathan Goodyear

Bisphenol A and Metabolic Syndrome: Results from NHANES - 0 views

www.hindawi.com/...598180

metabolic syndrome MetS bisphenol A BPA EDC endocrine disruptors

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Bisphenol A clearly associated with increased risk of MetS.
Nathan Goodyear

Effect of a High Protein Weight Loss Diet on Weight, High-Sensitivity C-Reactive Protei... - 0 views

www.hindawi.com/...971724

weight loss overweight obesity weight loss CRP protein diet

shared by Nathan Goodyear on 07 Aug 13 - No Cached
  • Nathan Goodyear on 07 Aug 13
     
    This study concludes that a energy restricted, high protein diet is more effective at weight loss than just a high protein diet.  There were also positive impacts on blood pressure, glucose, cholesterol, and hsCRP.
Nathan Goodyear

Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic rev... - 0 views

ije.oxfordjournals.org/...189.long

metabolic syndrome hormone hormones Testosterone SHBG

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    large meta analysis finds low Total Testosterone associated with in men and high Total Testosterone associated with MetS in women.  lower SHBG is associated with MetS
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.hindawi.com/...143763

low T Testosterone obesity type II diabetes diabetes health wellness metabolic syndrome lipids cholesterol hypogonadism TDS testicular dysgenesis syndrome men male hormone hormones prostate cancer

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
      Nathan Goodyear on 13 May 14
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
  • ...36 more annotations...
  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • A decline was noted in IL6 and TNF-alpha
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
Nathan Goodyear

Vitamin D and all-cause mortality among adults in USA: findings from the National Healt... - 0 views

ije.oxfordjournals.org/...998.abstract

vitamin vitamin d mortality nutrition health

shared by Nathan Goodyear on 10 Sep 11 - No Cached
  • Nathan Goodyear on 10 Sep 11
     
    low Vitamin D inversely related to mortality rates
Nathan Goodyear

Diagnosing Growth Hormone Deficiency in Adults - 0 views

www.hindawi.com/...972617

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • it is clear that serum IGF-1 and or IGFBP-3 can be normal in patients with undisputed GHD
  • Various investigators have reported normal IGF-1 values in 37–70% of GH deficient adults
  • The co-administration of arginine and GHRH (the combined test) is a powerful stimulus for GH production and has gained increasing acceptance as a useful method of diagnosing GHD [34]. This test has been advocated as a suitable alternative to ITT
  • ...12 more annotations...
  • The glucagon stimulation test (GST) is a reliable, safe alternative to the ITT in the diagnosis of GHD
  • An intravenous infusion of arginine (0.5 g/kg body weight) together with an intravenous bolus of GHRH (1 mcg/kg body weight) is administered [30]. Serum samples for GH are then obtained every 15–30 minutes for two hours.
  • Obesity, particularly marked obesity, is associated with blunted GH secretion in response to provocative stimuli
  • It has also been suggested that that even mildly increased BMI (25–30 kg/m2) can result in diminished stimulated GH production in 13% of healthy subjects
  • Corneli et al. have defined BMI-specific cut-off points for diagnosing adult-onset GHD using GHRH + arginine—11.5 ng/mL for those with BMI < 25 kg/m2, 8.0 ng/mL for BMI 25–30 kg/m2, 4.2 ng/mL for those with BMI > 30 kg/m2
  • GH levels are higher during the luteal phase in comparison with the follicular phase of the cycle
  • Oral, in contrast to transdermal oestrogen, lowers IGF-1 levels and is associated with increased GH levels
  • Adequate pituitary replacement with thyroxine and hydrocortisone are needed for optimal GH production
  • one cannot rely on a low IGF-1 to diagnose GHD in women taking oral oestrogen preparations.
  • Numerous GH secretagogues are available with the insulin tolerance test being the gold standard and the glucagon stimulation test or the GHRH + arginine as acceptable alternatives
  • ain et al. found the GST to be at least as good as the ITT in provoking GH secretion
  • the GST is safe, with almost no contraindications, it causes nausea and sometimes vomiting in 15–20% of subjects
  • Nathan Goodyear on 04 Nov 14
     
    Nice, more recent analysis, of HGH testing.
Nathan Goodyear

Sarcopenia and Age-Related Endocrine Function - 0 views

www.hindawi.com/...cta

Testosterone low T low testosterone low T muscle mass sarcopenia aging

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Good discussion of sarcopenia.  They article looked at the evidence of Testosterone and found the evidence pointed to improved lean muscle mass; but not a direct cause effect of low T and sarcopenia.
Nathan Goodyear

Effects of Long-Term Testosterone Therapy on Patients with "Diabesity": Results of Obse... - 0 views

www.hindawi.com/...683515

Testosterone therapy treatment men male hormone hormones diabetes hypogonadism health obese obesity glucose HgbA1c blood pressure hypertension CRP liver enzymes waist circumference low Testosterone low weight low T

shared by Nathan Goodyear on 15 Aug 14 - No Cached
  • Nathan Goodyear on 15 Aug 14
     
    Six years of Testosterone therapy in men with obesity, low T, and type II Diabetes was found to decrease waist circumference, decrease weight, decrease fasting glucose, decrease in HgbA1c and improved systolic/diastolic blood pressure, lipids, CRP, and liver enzymes.
Nathan Goodyear

The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers - 0 views

www.hindawi.com/...259676

CBD endocannabinoid cancer

shared by Nathan Goodyear on 13 Feb 19 - No Cached
  • Nathan Goodyear on 13 Feb 19
     
    Endocannabinoids and cancer.
1 - 14 of 14
Showing 20▼ items per page