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Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
Nathan Goodyear

A review on the association between inflammato... [Autoimmun Rev. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24001753

Macrophagic myofasciitis vaccine vaccines vaccinations inflammation

shared by Nathan Goodyear on 01 Oct 14 - No Cached
  • Nathan Goodyear on 01 Oct 14
     
    Author states that there may be a link between vaccine adjuvants and post-vaccine myopathies as in macrophagic myofasciitis.  He concludes with "the concept of a possible causal link between immunization and inflammatory myopathies should not be totally rejected".  Not associated, but causal.
Nathan Goodyear

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 | ... - 0 views

embomolmed.embopress.org/...721.full

NAD nicotinamide riboside mitochondria vitamin B3 ATP disease

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    NAD in the form of nicotinamide riboside found to be effective in treating mitochondrial myopathy in animal model.
Nathan Goodyear

Statin-Associated Myopathy with Normal Creatine Kinase Levels - 0 views

www.annals.org/...581.full.pdf+html

statins statin muscle cells mitochondria CoQ10 energy myopathy necrosis

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    Statins shown to damage the cells ability to make energy and resultant muscle damage occurs.
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