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Nathan Goodyear

Hepatoprotective Effect of Vitamin C (Ascorbic Acid) - 0 views

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    Vitamin C is hepatoprotective.  This review highlights the proposed methods by which vitamin C reduces ALT, AST, alkaline phosphatase, LDH, malondialdegyde...
Nathan Goodyear

Obesity - Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relati... - 0 views

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    obesity is dynamically complex!
Nathan Goodyear

Obesity - Abstract of article: Body Weight Loss and Weight Maintenance in Relation to H... - 0 views

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    oolong green tea shown to work synergistically with caffeine to increase thermogenesis and fat oxidation resulting in weight loss.  Nature always seems to provide the right balance of chemicals to give the best results. 
Nathan Goodyear

Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic... - 0 views

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    Testosterone therapy followed over 5 years in hypogonadal men found physiologic replacement of Testosterone decreased Total cholesterol, decreased LDL, increased HDL, decreased blood pressure, decreased blood glucose, decreased HgbA1c, decreased CRP, ALT, and AST. All men with metabolic syndrome  should have appropriate hormone evaluation done.
Nathan Goodyear

Transaminase Levels and Vigorous Exercise - 0 views

  • We accept 1–2 times the upper limit of normal to be attributable to exercise
  • Some physicians, whether they are gastroenterol-ogists or internists, forget that exercise can cause this abnormality
  • it is good for patients with liver disease to exercise, particularly those with fatty liver disease
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  • we see a trend toward improved ALT and AST levels in patients performing moderate exercise, regardless of the etiology of their liver disease
  • We therefore discourage very heavy exercise in these patients, but a moderate amount does not cause a problem
  • once enzymes are abnormal, they remain abnormal for up to 1 week. Were subjects to exercise vigorously again during that week, transaminase levels could increase further
  • there is a ratio that in healthy individuals is considered normal. AST levels normally measure at approximately 0.8 of ALT levels. A dysregularity of this ratio can also signal hepatic illness but usually inflammation of any kind affects both measures
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    Vigorous exercise yields abnormal liver enzymes.  How one defines vigorous exericse is going to vary from person to person.
Nathan Goodyear

American Journal of Hypertension - Abstract of article: Superoxide Scavenging Effects o... - 0 views

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    IV vitamin C therapy shown to improved the response of blood pressure to acetylcholine and nitroprusside in those patients with essential hypertension.  This effect was not found in NAC.  Vitamin C acts as a superoxide scavenger and glutathione recycler.
Nathan Goodyear

Obesity - Relationship of Plasma Adiponectin With Sex Hormone and Insulin-like Growth F... - 0 views

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    adiponectin inversely associated with estrogen levels.  
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

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    Nice review of elevated liver enzymes.
Nathan Goodyear

Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in ... - 0 views

  • Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P<0.05)
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    study finds soccer training is associated with increased oxidative stress as measured by TBARS, SOD, superoxide anion and other oxidative stress load biomarkers.  Astaxanthin was associated with less oxidative stress.
Nathan Goodyear

Annals of Occupational and Environmental Medicine | Full text | The Relationship of Liv... - 0 views

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    Lead and organic solvent exposure associated with increased liver function tests, indicating liver damage.
Nathan Goodyear

Evaluation of abnormal liver function tests | Postgraduate Medical Journal - 0 views

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    Nice review on liver function tests.
Nathan Goodyear

The Contribution of Cytotoxic Chemotherapy to 5-year Survival in Adult Malignancies | C... - 0 views

  • In this group, the 5-year survivalrateduesolelytocytotoxicchemotherapywas14%
  • There is also no convincing evidence that usingregimens with newer and more expensive drugs are anymore beneficial than the regimens used in the 1970s
  • two systematic reviews of chemotherapy inrecurrent or metastatic breast cancer have not been able toshow any survival benefit
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  • The five most common adult malignancies (colorectal, breast, prostate, melanoma and lung cancer)
  • n breast cancer, the optimal regimen(s) for cytotoxicchemotherapy in recurrent/metastatic disease are still notdefined, despite over 30 years of ‘research’ and a plethora of RCTs since the original Cooper regimen was published in1969
  • The five most ‘chemo-sensitive’ cancers,namely testis, Hodgkin’s disease and non-Hodgkin’s lym- phoma, cervix and ovary
  • only 13 out of the 22 malignancies evaluated showed any improvement in 5-year survival, and theimprovement was greater than 10% in only three of those13 malignancies
  • the contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults is 2.3% in Australia and 2.1% in the USA
  • a benefit of less than 2.5% is likely to be applicable in other developed countries
  •   Overview The Contribution o
  • the benefit of cytotoxic chemotherapy may have been overestimated for cancers of oesophagus, stomach,rectum and brain.
  • this reflects the presentation of results as a ‘reduction in risk’ rather than asan absolute survival benefit[89,90]and by exaggerating theresponse rates by including ‘stable disease’
  • recent studies have documented impaired cognitive function inwomen receiving adjuvant treatment for breast cancer
  • the 5-year survival rate due solely to cytotoxicchemotherapy was 1.6%
  • the value of palliative chemotherapy has beenquestioned
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    Incredibly low impact of cytotoxic chemotherapy despite its wide spread utilization.  This article referenced cost yet did not evaluate the cost of cytotoxic side effect.  The question to answer: is Cytotoxic chemotherapy a valid treatment, at all, for the majority of cancers.
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