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Nathan Goodyear

Low-Dose Transdermal Testosterone Therapy Improves Angina Threshold in Men With Chronic... - 0 views

circ.ahajournals.org/...1906.abstract

Testosterone therapy angina ST depression heart cardiovascular disease men male hormone hormones

shared by Nathan Goodyear on 03 Dec 13 - No Cached
  • Nathan Goodyear on 03 Dec 13
     
    Small study finds low dose Testosterone, 5 mg over 12 weeks, reduced exercise induce myocardial ischemia through an increase in time to ST segment depression.
Nathan Goodyear

Cyclooxygenase inhibition reduces blood p... [Clin Exp Hypertens. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10744360

cyclooxygenase NO Hg mercury heart health COX cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.
Nathan Goodyear

Endothelial dysfunction of rat coronary arteries after exposure to low concentrations o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3081124

Hg mercury NO cardiovascular disease heart health ROS reactive oxygen species oxidative stress

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    low dose, chronic exposure induces ROS and decreased NO availability.  This decrease in NO will result in increase vasoconstriction.  This will have localized effects and will result in increased central pressure as a result of the increased peripheral pressure.  In addition, inhibition of COMT will result in increase in catecholeamines.
Nathan Goodyear

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks - 0 views

hyper.ahajournals.org/...463.long

Pb lead hypertension CVD cardiovascular disease heart health

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Lead is associated with elevated blood pressure in black people, though no association is found in white people.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehv346

low T low Testosterone men Testosterone mortality stroke MI CVD cardiovascular disease hormones male

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Normalized-TRT group had significantly fewer deaths than no-TRT
  • Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
  • the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
  • ...10 more annotations...
  • normalized-TRT group showed lower risk of MI than non-normalized-TRT (HR: 0.82, CI 0.71–0.95, P = 0.008) and no-TRT
  • normalized-TRT group had significantly lower stroke events compared with non-normalized-TRT (HR: 0.70, CI 0.51–0.96, P = 0.028) and no-TRT
  • study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes
  • retrospective study
  • the first study to demonstrate that significant benefit is observed only if the dose is adequate to normalize the TT levels
  • Patients who failed to achieve the therapeutic range after TRT did not see a reduction in MI or stroke and had significantly less benefit on mortality
  • selected patients without any previous history of MI or stroke prior to initiation of TRT to reduce bias related to CV outcomes
  • currently only half of the men on TRT had been diagnosed with hypogonadism.
  • 25% of users did not have their T concentrations tested prior to initiating therapy, and 21% of those prescribed TRT did not have their levels tested at any time during treatment.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • Nathan Goodyear on 11 Aug 15
     
    Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.
Nathan Goodyear

Interaction of 5-methyltetrahydrofolate and tetrah... [Am J Physiol Heart Circ Physiol.... - 0 views

www.ncbi.nlm.nih.gov/...12003825

5-methyltetrahydrofolate tetrahydropbiopterin NO endothelial vascular function cardiovascular disease

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • We demonstrate that 5-methyltetrahydrofolate binds the active site of nitric oxide synthase and mimics the orientation of tetrahydrobiopterin
  • 5-methyltetrahydrofolate attenuates superoxide production (induced by inhibition of tetrahydrobiopterin synthesis) and improves endothelial function
  • e suggest that 5-methyltetrahydrofolate directly interacts with nitric oxide synthase to promote nitric oxide (vs. superoxide) production and improve endothelial function
  • ...1 more annotation...
  • 5-Methyltetrahydrofolate may represent an important strategy for intervention aimed at improving tetrahydrobiopterin bioavailability.
  • Nathan Goodyear on 29 Apr 11
     
    5-methyltetrahydrofolate promotes NO synthase and improves endothelial vascular function;  proposed as way to increase tetrahydropbiopterin
Nathan Goodyear

http://eurheartj.oxfordjournals.org/content/26/16/1633.full.pdf - 0 views

eurheartj.oxfordjournals.org/...1633.full.pdf

Lp(a) lipoprotein(a) cardiovascular disease risk heart health

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Lp(a) associated with increased risk at levels > 30 in women.  The risk is double.
Nathan Goodyear

Coronary Artery Calcium Scores: Current Thinking and Clinical Applications - 0 views

www.ncbi.nlm.nih.gov/...PMC2627524

coronary artery calcium cardiovascular disease heart health risk

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    coronary artery calcium scores
Nathan Goodyear

Apolipoproteins versus lipids as indices of coronary risk and as targets for statin tre... - 0 views

www.thelancet.com/...fulltext

lipoproteins Apolipoprotein B apo B CVD cardiovascular disease risk heart health

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    apo B is a surrogate marker for LDL particle #.  However, it is an independent risk biomarker itself.
Nathan Goodyear

High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fat... - 0 views

www.thelancet.com/...fulltext

lipoproteins apolipoproteins apo B apo A1 Apo B:Apo A1 Apolipoprotein B Apolipoprotien A1 cholesterol heart health cardiovascular disease risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Study finds strong correlation between Apo B and Apo B:apo A1 in fatal MI risk in men and women.  Apo B was a stronger than LDL in predicting risk in men and women.  Apo A1 was noted to be protective, but the stats were less strong.
Nathan Goodyear

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D and Postoperative Outcome in Cardiac Surge... - 0 views

press.endocrine.org/...jc.2014-3013

vitamin D CVD cardiovascular disease heart health cerebrovascular CVA surgery

shared by Nathan Goodyear on 14 Jan 15 - No Cached
  • Nathan Goodyear on 14 Jan 15
     
    low vitamin D predicts increased risk of Major adverse cardiac and/or cerebrovascular events after cardiac surgery.  The definition of low D was <30.  A better study would have been to stratify by 10s the risk.
Nathan Goodyear

Reverse T3 as a parameter of myocardial functi... [Int J Cardiol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19428128

thyroid hormone hormones reverse T3 fT3_rT3 rT3 heart failure CHF cardiovascular disease.

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Another study regarding reverse T3 that many Endocrinologists need to read.  In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV.  This MFI class IV was also found associated with a decreased fT3/rT3.
Nathan Goodyear

Risk of Myocardial Infarction in Older Men Receiving Testosterone Therapy - 0 views

aop.sagepub.com/...1138.abstract

testosterone therapy treatment MI heart disease cardiovascular men male hormone hormones health men's health

shared by Nathan Goodyear on 15 Aug 14 - No Cached
  • Nathan Goodyear on 15 Aug 14
     
    Testosterone therapy in older men found to provide no increase in MI risk.  In fact, those men with high MI risk, Testosterone provided protection against MI.
Nathan Goodyear

http://circ.ahajournals.org/content/109/7/837.full.pdf - 0 views

circ.ahajournals.org/...837.full.pdf

LP-PLA2 lipoprotein-associated phospholipase A2 CVD cardiovascular disease heart heath CHD hsCRP

shared by Nathan Goodyear on 15 Apr 15 - No Cached
  • Nathan Goodyear on 15 Apr 15
     
    LP-PLA2 (Lipoprotein-Associated Phospholipase A2) with hs-CRP are associated with increased CHD events in those with low LDL-C.
Nathan Goodyear

American College of Cardiology Foundation | Article - 0 views

content.onlinejacc.org/...article.aspx

CoQ10 aged garlic extract AGE LP-PLA2 heart health lipoprotein-associated phospholipase A2 CAD CVD cardiovascular disease

shared by Nathan Goodyear on 15 Apr 15 - No Cached
  • Nathan Goodyear on 15 Apr 15
     
    Poster found that aged garlic extract plus CoQ10 slowed coronary artery calcification and decreased Lp-PLA2 compared to placebo.
Nathan Goodyear

Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Ty... - 0 views

annals.org/article.aspx

wine CVD cardiovascular disease heart health diabetes mediterranean diet alcohol

shared by Nathan Goodyear on 10 Dec 15 - No Cached
  • Nathan Goodyear on 10 Dec 15
     
    wine, red and white, with a mediterranean diet reduced cardiometabolic risk  in individuals with diabetes.  The volume of nightly intake of wine was 5 oz.
golibeetscardio

Goli Nutrition Beets Cardio Gummies- Goli Beets Cardio Gummies, Reviews! - 1 views

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started by golibeetscardio on 05 Aug 23 no follow-up yet
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