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Interaction of 5-methyltetrahydrofolate and tetrah... [Am J Physiol Heart Circ Physiol.... - 0 views

www.ncbi.nlm.nih.gov/...12003825

5-methyltetrahydrofolate tetrahydropbiopterin NO endothelial vascular function cardiovascular disease

shared by Nathan Goodyear on 29 Apr 11 - No Cached

We demonstrate that 5-methyltetrahydrofolate binds the active site of nitric oxide synthase and mimics the orientation of tetrahydrobiopterin
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5-methyltetrahydrofolate attenuates superoxide production (induced by inhibition of tetrahydrobiopterin synthesis) and improves endothelial function
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e suggest that 5-methyltetrahydrofolate directly interacts with nitric oxide synthase to promote nitric oxide (vs. superoxide) production and improve endothelial function
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...1 more annotation...
5-Methyltetrahydrofolate may represent an important strategy for intervention aimed at improving tetrahydrobiopterin bioavailability.
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Nathan Goodyear on 29 Apr 11

5-methyltetrahydrofolate promotes NO synthase and improves endothelial vascular function; proposed as way to increase tetrahydropbiopterin

<div class="cArrow"> </div><div class="cContentInner">5-methyltetrahydrofolate promotes NO synthase and improves endothelial vascular function; proposed as way to increase tetrahydropbiopterin</div>

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5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide... - 0 views

circ.ahajournals.org/...1193.long

BH4 5-methyltetrahydrofolate tetrahydrobiopterine MTHFR MTHFR A1298C eNOS NO nitric oxide atherosclerosis cardiovascular disease CVD

shared by Nathan Goodyear on 14 Sep 17 - No Cached

Nathan Goodyear on 14 Sep 17

5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis. Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.

<div class="cArrow"> </div><div class="cContentInner">5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis. Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.</div>

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Influence of Oral S-Adenosylmethionine on Plasma 5-Methyltetrahydrofolate, S-Adenosylho... - 0 views

jpet.aspetjournals.org/...845.long

SAMe 5-MTHF homocysteine

shared by Nathan Goodyear on 25 Jun 12 - No Cached

Nathan Goodyear on 25 Jun 12

SAMe replacement, 400 mg, did not raise homocysteine. But, it did increase 5-MTHF.

<div class="cArrow"> </div><div class="cContentInner">SAMe replacement, 400 mg, did not raise homocysteine. But, it did increase 5-MTHF.</div>

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