Endothelial dysfunction of rat coronary arteries after exposure to low concentrations o... - 0 views
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low dose, chronic exposure induces ROS and decreased NO availability. This decrease in NO will result in increase vasoconstriction. This will have localized effects and will result in increased central pressure as a result of the increased peripheral pressure. In addition, inhibition of COMT will result in increase in catecholeamines.
Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views
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Normalized-TRT group had significantly fewer deaths than no-TRT
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Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
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the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
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Interaction of 5-methyltetrahydrofolate and tetrah... [Am J Physiol Heart Circ Physiol.... - 0 views
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We demonstrate that 5-methyltetrahydrofolate binds the active site of nitric oxide synthase and mimics the orientation of tetrahydrobiopterin
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5-methyltetrahydrofolate attenuates superoxide production (induced by inhibition of tetrahydrobiopterin synthesis) and improves endothelial function
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e suggest that 5-methyltetrahydrofolate directly interacts with nitric oxide synthase to promote nitric oxide (vs. superoxide) production and improve endothelial function
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