The importance of calcium, potassium, and acid-base homeostasis in bone health and osteoporosis prevention.
Tylavsky FA, Spence LA, Harkness L.
J Nutr. 2008 Jan;138(1):164S-165S.
PMID: 18156418
In concert with the acid-base literature, protein intake is considered to be a net acid-producing substance and thus a net negative risk factor for bone dissolution. However, substantial literature supports the beneficial effects on skeletal metabolism when higher protein levels are consumed in concert with adequate calcium, potassium, and other minerals, regardless of the source of protein (24-26). The Dietary Approaches to Stopping Hypertension (DASH) diet (27) is a calcium-rich diet that emphasizes fruits, vegetables, and low-fat dairy products. This diet underscores the importance of consuming a complement of foods from meats, grains, dairy, fruits, and vegetables as prudent for promoting optimal bone health. In the following articles, Rafferty and Lanham-New carefully review the evidence on the interaction of specific diet components that impact bone health and conclude that a balanced diet with recommended servings of dairy products and a variety of fruits and vegetables is prudent for optimal bone health. Additionally, they comment on future research directions for consideration by the scientific community.
Our findings suggest that administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters.
N-3 fatty acids, cancer and cachexia: a systematic review of the literature.
Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C.
Br J Nutr. 2007 May;97(5):823-31. Review.
PMID: 17408522
doi:10.1017/S000711450765795X
[Effects of dietetic supplementation with L-arginine in cancer patients. A review of the literature]
Novaes MR, Lima LA.
Arch Latinoam Nutr. 1999 Dec;49(4):301-8. Review. Portuguese.
PMID: 10883292
Vitamin D deficiency: a worldwide problem with health consequences.
Holick MF, Chen TC.
Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. Review.
PMID: 18400738
A reevaluation needs to take place of what the adequate intakes of vitamin D should be for children and adults. The literature over the past decade suggests that the Institute of Medicine recommendations in 1997 (83) are inadequate, and some experts including us suggest that both children and adults should take ≥800-1000 IU vitamin D/d from dietary and supplemental sources (4, 9, 77) when sunlight is unable to provide it. This recommendation, however, has not yet been embraced either by official government or pediatric organizations in the United States, Canada, or Europe for either children or adults.
Dietary Reference Intakes for Vitamin D and Calcium
An IOM committee has been named to undertake a study to assess current relevant data and update as appropriate the DRIs for vitamin D and calcium. The review will include consideration of chronic and non-chronic disease indicators. The study will also incorporate, as appropriate, systematic evidence-based reviews of the literature and an assessment of potential indicators of adequacy and of excess intake. Indicators for adequacy and excess will be selected based on the strength and quality of the evidence and the demonstrated public health significance, taking into consideration sources of uncertainty in the evidence.
Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004.
Melamed ML, Muntner P, Michos ED, Uribarri J, Weber C, Sharma J, Raggi P.
Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1179-85. Epub 2008 Apr 16.
PMID: 18417640
doi: 10.1161/ATVBAHA.108.165886
Conclusions- Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association.
Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed.
The review, published in Osteoporosis International, provides a global perspective of vitamin D status across different regions of the world and identifies common and significant determinants of hypovitaminosis D. Six regions of the world were reviewed-Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania-through a survey of published literature.
Active Hexose Correlated Compound (AHCC) is an alpha-glucan rich nutritional supplement produced from the mycelia of shiitake (Lentinula edodes) of the basidiomycete family of mushrooms, and should not be confused or used as a drug or medicine.[1][2] AHCC was originally designed to lower high-blood pressure. However, researchers at Tokyo University found AHCC's influence upon the innate immune system highly beneficial and published the results in 1992, though not in the commonly indexed scientific literature. In this study, researchers found that AHCC significantly increased natural killer (NK) cell activity in cancer patients, and also enhanced the effects of killer T-cells, and cytokines (interferon, IL-12, TNF-alpha
A large number of new vitamin D studies have appeared in the scientific literature since I wrote my plea to the federal government. These studies don't just confirm what we knew 16 months ago-they show that optimizing vitamin D intake will save even more lives than what we projected.
Vitamin D More Effective Than Previously Known
For instance, a study published in June 2008 showed that men with low vitamin D levels suffer 2.42 times more heart attacks. Now look what this means in actual body counts.
Eicosapentaenoic acid (EPA or also icosapentaenoic acid) is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). It also has the trivial name timnodonic acid. Chemically, EPA is a carboxylic acid with a 20-carbon chain and f
Dihomo-gamma-linolenic acid (DGLA) is 20-carbon ω-6 fatty acid. In physiological literature, it is given the name 20:3(n-6). Chemically, DGLA is a carboxylic acid with a 20-carbon chain and three cis double bonds; the first double bond is located at the
"The diet-heart hypothesis is the idea that saturated fat, and in some versions cholesterol, raises blood cholesterol and contributes to the risk of having a heart attack. To test this hypothesis, scientists have been studying the relationship between saturated fat consumption and heart attack risk for more than half a century. To judge by the grave pronouncements of our most visible experts, you would think these studies had found an association between the two. It turns out, they haven't.
The fact is, the vast majority of high-quality observational studies have found no connection whatsoever between saturated fat consumption and heart attack risk. The scientific literature contains dozens of these studies, so let's narrow the field to prospective studies only, because they are considered the most reliable. In this study design, investigators find a group of initially healthy people, record information about them (in this case what they eat), and watch who gets sick over the years."
"One of the very useful oils in the food supply comes from the coconut. Coconut oil has suffered from unjust criticism for more than 30 years in the United States because some of the governmental and food oil organizations, as well as consumer activist organizations such as Center for Science in the Public Interest (CSPI), have claimed that coconut oil as a "saturated fat" is shown to be atherogenic. This is not true.
There is a variety of supportive research published in 2003, 2004, and 2005, which shows the importance of coconut oil. Also, information on coconut oil is currently coming into the research literature from numerous countries, including India, Norway, Iran and the United States.
The following are some of the most recent studies showing the benefits of coconut oil. These studies contradict claims that coconut oil contributes to heart disease and also support earlier research showing an antimicrobial role for the fatty acids in this traditional fat."
"Friday, December 18, 2009
Omega 3 Fatty Acid and Adiponectin Levels
Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects:
* reduces liver glucose production
* increases glucose uptake in the muscles and adipose tissues
* causes oxidation of fats which leads to less lipid production
* has anti-inflammatory properties
* protects the heart against ischemia and reduces myocardial infarct size
* acts as an anti-clotting factor
* increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.
Mooradian AD, Haas MJ, Wong NC.
Endocr Rev. 2006 Feb;27(1):2-16. Epub 2005 Oct 21. Review.
PMID: 16243964
One of the factors contributing to the increased risk of developing premature atherosclerosis is low plasma concentrations of high-density lipoprotein (HDL) cholesterol (HDLc). Multiple potential mechanisms account for the cardioprotective effects of HDL and its main protein apolipoprotein A-I (apo A-I). The low plasma concentrations of HDL could be the result of increased fractional clearance and reduced expression of apo A-I. To this end, nutrients play an important role in modulating the fractional clearance rate, as well as the rate of apo A-I gene expression. Because medical nutrition therapy constitutes the cornerstone of management of dyslipidemias, it is essential to understand the mechanisms underlying the changes in HDL level in response to alterations in dietary intake. In this review, we will discuss the effect of select nutrients on serum HDLc and apo A-I levels. Specifically, we will review the literature on the effect of carbohydrates, fatty acids, and ketones, as well as some of the nutrient-related metabolites, such as glucosamine and the prostanoids, on apo A-I gene expression. Because there are multiple mechanisms involved in the regulation of serum HDLc levels, changes in gene transcription do not necessarily correlate with clinical observations on serum levels of HDLc.
"For what reason I don't know, but this January 2009 editorial by William Faloon of the Life Extension Foundation is making the rounds. Perhaps it just came available on the web.
It's a good read, particularly in light of the billions and trillions of dollars the thieves & thugs in DC are about to flush down the crapper on your behalf. Some notable excerpts.
A large number of new vitamin D studies have appeared in the scientific literature since I wrote my plea to the federal government. These studies don't just confirm what we knew 16 months ago-they show that optimizing vitamin D intake will save even more lives than what we projected.
For instance, a study published in June 2008 showed that men with low vitamin D levels suffer 2.42 times more heart attacks. Now look what this means in actual body counts.
Each year, about 157,000 Americans die from coronary artery disease-related heart attacks. Based on this most recent study, if every American optimized their vitamin D status, the number of deaths prevented from this kind of heart attack would be 92,500.
To put the number of lives saved in context, tens of millions of dollars are being spent to advertise that Lipitor® reduces heart attacks by 37%. This is certainly a decent number, but not when compared with how many lives could be saved by vitamin D. According to the latest study, men with the higher vitamin D levels had a 142% reduction in heart attacks."
Is the MP Treatment for Sarcoidosis Helpful for Other Chronic Diseases?
MP's Vitamin D Theories Are Not Supported by Lab Studies.
Updated July 2, 2008
"The MP treatment plan was originally designed to treat an inflammatory condition known as sarcoidosis. The treatment consists of using the drug Benicar, combined with the avoidance of all sources of vitamin D, and eventually adding various antibiotics, especially minocycline. After being used by sarcoidosis patients for some years, it was then theorized and claimed that the treatment could treat other inflammatory conditions. Eventually it was also claimed that it could treat fibromyalgia and CFS, conditions which are not recognized by the medical literature as being inflammatory in nature. "
Omega 3 fatty acids and the brain: review of studies in depression.
Sinclair AJ, Begg D, Mathai M, Weisinger RS.
Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7. Review.
PMID: 17392137
This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties.
"This is an alphabetical list of Foods containing Lectins, from edible Plant and Animal sources.
Most lectins, in plant species, are NOT ABO blood type specific. Even fewer EDIBLE plants have lectins that are ABO type specific.
This list does conflict with the information of the various incarnations of 'blood type diets', as far as specific foods agglutinating certain of the ABO blood types only. However, this information below has been derived directly from the published scientific literature and studies which are listed in the references which follow this list. It is not known where the authors of these diet books came up with their ABO blood-type agglutination data, it is definitely false when compared to published scientific studies.
The first section has a list of foods, in alphabetical order for easier searching, their scientific names, and which blood types are agglutinated by them."
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