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"We are aware of substantial scientific evidence supporting the role of vitamin D in prevention of cancer. It has been reasonably established that adequate serum vitamin D metabolite levels are associated with substantially lower incidence rates of several types of cancer, including those of the breast, colon, and ovary, and other sites. We have concluded that the vitamin D status of most individuals in North America will need to be greatly improved for substantial reduction in incidence of cancer. Epidemiological studies have shown that higher vitamin D levels are also associated with lower risk of Type I diabetes in children and of multiple sclerosis. Several studies have found that markers of higher vitamin D levels are associated with lower incidence and severity of influenza and several other infectious diseases."

Severe vitamin D deficiency in Swiss hip fracture patients. Bischoff-Ferrari HA, Can U, Staehelin HB, Platz A, Henschkowski J, Michel BA, Dawson-Hughes B, Theiler R. Bone. 2008 Mar;42(3):597-602. Epub 2007 Nov 28. PMID: 18180211 BACKGROUND: Most clinical guidelines for the prevention of hip fractures recommend 800 IU vitamin D per day. This dose shifted serum 25-hydroxyvitamin D levels (25(OH)D) in previous studies to between 60 and 100 nmol/l. AIM: To measure 25(OH)D levels and prevalence of vitamin D supplementation in individuals age 65+ with acute hip fracture. METHODS: 222 consecutive hip fracture patients were investigated over a 12 month period. Mean age of patients was 86 years and 77% were women. RESULTS: Mean serum 25(OH)D levels were low among hip fracture patients admitted from home (34.6 nmol/l), from assisted living (27.7 nmol/l), and from nursing homes (24 nmol/l). Severe vitamin D deficiency below 30 nmol/l was present in 60%, 80% were below 50 nmol/l, and less than 4% reached desirable levels of at least 75 nmol/l. Consistently, only 10% of hip fracture patients had any vitamin D supplementation on admission to acute care with significantly higher 25(OH)D levels among individuals supplemented with 800-880 IU/day (63.5 nmol/l). Controlling for age and gender, vitamin D supplementation, type of dwelling, and season were independently and significantly associated with 25(OH)D levels. CONCLUSION: These data provide evidence that current guidelines for the prevention of hip fractures need further effort to be translated into clinical practice.

Hundreds of miraculous health benefits are associated with the consumption of lemon juice. In this article, I have elaborated on the top ten amongst all the lemon juice benefits. Lemon enjoys a global eminence, thanks to its incredible health benefits. Several advantages are also associated with the consumption of this tangy juice. Scroll down and enjoy the read. Lemon Juice: Prevents Cancer Lemon is well-known for its richness in multipurpose flavonoid compounds which defend your body against different types of cancer. Thus, regular consumption of lemon juice ensures the prevention of cancerous cells. Lemon Juice: Treat the Upset Stomach Lemon juice is a marvellous drink for people who are suffering from an upset stomach. Digestive problems like diarrhoea or constipation make you feel uncomfortable in addition to botching up your daily routine. To deal with such problems, intake one glass lemon water at the start of the new day. You can maximize the benefits by adding one teaspoon of honey to this solution. Lemon Juice: Good for Liver One of the main advantages of lemon juice is its assistance in improving the liver function and flushing out the toxins from the body. This zesty fruit increase the production of bile in the body that is required for breaking down the fats and lipids. Lemon Juice: Assists in dealing with infections Lemons contain a high amount of Vitamin C, which is essential for strengthening the immune system. So, consuming it in any form is a natural way to prevent viral infections like cold and flu. Lemon water also aids in treating urinary tract infections. Lemon Juice: Best for Hypertension Patients People, who don't consume sufficient amount of potassium, are at higher risks of getting affected by cardiological disorders. Lemon juice contains a satisfactory amount of potassium, so it can help in reducing the risks of such problems. Lemon Juice: Acts as Natural Cleanser for Skin The cleansing properties of lemon juice

Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C Salvatore Petta et al. Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009 DOI: 10.1002/hep.23489 Conclusions: G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)

Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. More recently, it has become clear that receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects which extend far beyond control of mineral metabolism. The active form of vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Each of the forms of vitamin D is hydrophobic, and is transported in blood bound to carrier proteins. The major carrier is called, appropriately, vitamin D-binding protein. The halflife of 25-hydroxycholecalciferol is several weeks, while that of 1,25-dihydroxycholecalciferol is only a few hours. The vitamin D receptor binds several forms of cholecalciferol. Its affinity for 1,25-dihydroxycholecalciferol is roughly 1000 times that for 25-hydroxycholecalciferol, which explains their relative biological potencies

Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. Hollis BW, Wagner CL, Drezner MK, Binkley NC. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):631-4. Epub 2007 Jan 10. PMID: 17218096 In the present study, we sought to investigate what circulating 25(OH)D levels would result in populations exhibiting no substrate limitations to the vitamin D-25-hydroxylase. To perform this, we chose two distinct populations. The first were individuals from a year-found sunny environment who spent a good deal of time outdoors. The second were a group of lactating women receiving a substantial daily oral dose of vitamin D3. Surprisingly, a study such as this previously had not been undertaken. There are several reasons for this. First, finding a group of sun-exposed individuals is not an easy task; in fact, we had to go to Hawaii to find them. Secondly, very few studies have been performed where subjects actually received adequate vitamin D3 supplementation to make them replete. Finally, it is very difficult and costly to measure circulating vitamin D3 and relate it to circulating 25(OH)D. The results of our study are far-reaching. This study also demonstrates that individuals can be vitamin D deficient with significant sun exposure if the skin area exposed is limited as was suggested several years ago (19). Finally, whether one receives their vitamin D3 orally or through UV exposure, the vitamin D-25-hydroxylase appears to handle it in an equivalent fashion with respect to maintaining circulating 25(OH)D levels. Thus, we believe that the relationship between circulating vitamin D and 25(OH)D may define adequate nutritional vitamin D status.

[Severe hypercalcemia due to vitamin D intoxication] Chambellan-Tison C, Horen B, Plat-Wilson G, Moulin P, Claudet I. Arch Pediatr. 2007 Nov;14(11):1328-32. Epub 2007 Oct 10. French. PMID: 17931839

Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. Celik GE, Erkekol FO, Misirligil Z, Melli M. Clin Exp Allergy. 2007 Oct;37(10):1494-501. PMID: 17883729 DOI: 10.1111/j.1365-2222.2007.02806.x

Derived from the bulb or clove of the plant. Garlic is used as a spice and to treat hyperlipidemia, hypertension, atherosclerosis, cancer, and infections. Processing can have a substantial effect on the chemical content in garlic; the volatile oil components are sensitive to heat and certain enzymes are acid-labile. Several oral garlic formulations are available, and clinical studies have addressed a variety of the proposed claims. Placebo-controlled trials on the cholesterol lowering effect of garlic yielded mixed results (16) (17) (18) (21) (22) (26). Studies evaluating the antithrombotic effects repeatedly have shown modest reduction in platelet aggregation, but varying levels of fibrinolytic activity. Research shows mixed effects with regard to reductions in blood glucose, blood pressure, or risk of cardiovascular disease (23). Frequently reported adverse events include bad breath, headache, fatigue, GI upset, diarrhea, sweating, and possible hypoglycemia (9). Because garlic is known to decrease platelet aggregation and potentially elevate the INR, it should not be used with anticoagulants or in patients with platelet dysfunction (15). Garlic appears to induce cytochrome p450 3A4 and may enhance metabolism of many medications (e.g. cyclosporin and saquinavir) (12). An analysis of several case-control studies in Europe suggests an inverse association between garlic consumption and risk of common cancers (25).

In April of 2000 a clinical observation published in Archives of Internal Medicine caught my attention. Dr. Anu Prabhala and his colleagues reported on the treatment of five patients confined to wheelchairs with severe weakness and fatigue. Blood tests revealed that all suffered from severe vitamin D deficiency. The patients received 50,000 IU vitamin D per week and all became mobile within six weeks.1\n\nDr. Prabhala's research sparked my interest and led to a search for current information on vitamin D, how it works, how much we really need and how we get it. The following is a small part of the important information that I found.

Vitamin D, aging, and cancer. Tuohimaa P. Nutr Rev. 2008 Oct;66(10 Suppl 2):S147-52. Review. PMID: 18844842 DOI: 10.1111/j.1753-4887.2008.00095.x Deficiency of the prohormone calcidiol (25OH vitamin D3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined.

Vitamin D, nervous system and aging. P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. . Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286 NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION doi:10.1016/j.psyneuen.2009.07.003 This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.

Skin infection is the most annoying one to deal with as this infection causes itching and burning sensation. This is quite disturbing as itching may occur at any time and during this "itching outbreak" you won't be able resist yourself from scratching the affected part. Eczema is one of the skin infections whose exact cause is not clear. But there are treatment options available such as use of clobetasol cream which is also known as Generic Temovate. This is the topical treatment for eczema which known to ease the burning sensation and itching. Eczema is generally defined as atopic dermatitis, characterized by reddening and swelling of the affected area. The body part or the section of the skin which gets affected becomes very itchy. The severity of infection and itching vary from person to person. In mild eczema infection the skin is dry and itchy and hot to touch. A severe infection shows broken, raw and bleeding skin. Skin rashes that itch a lot is the most common symptom of eczema. The reduction in itching is the primary step in the treatment for eczema.

Now food Zinc Gluconate 50 mg, 250-Count for of its insufficiency: Zinc may be used for treatment in addition to deterrence with regard to zinc deficit & it's final results, for example reduced improvement in addition to serious diarrhea inside children, in addition to slow damage recuperation. Zinc for enhancing the body protection System: It's furthermore useful for enhancing the particular disease fighting capability, working most abundant in well-liked frosty in addition to repetitive listening to transmissions, in addition to preventing decrease breathing transmissions. It's furthermore useful for malaria as well as other ailments due to undesirable microorganisms. Now food Zinc Gluconate 50 mg, 250-Count, for the Muscle wellness: Lots of people take advantage of zinc to have interest sickness referred to as muscle destruction, with regard to night lack of view, in addition to regarding cataracts. It's furthermore useful for asthma; diabetes; greater blood stream tension; acquired immunodeficiency condition (AIDS); in addition to skin pores & pores and skin difficulties, for instance psoriasis, eczema, in addition to pimples. Zinc for the entire body illnesses, problems: Extra makes use of contain coping with curiosity deficit-hyperactivity situation (ADHD), blunted sensation related to taste (hypogeusia), ringing in the ears (tinnitus), severe thoughts accidents, Crohn's sickness, Alzheimer's sickness, Reduce condition, Hansen's sickness, ulcerative colitis, peptic ulcers in addition to marketing lbs acquire inside people with eating difficulties for instance anorexia nervosa. Now food Zinc Gluconate 50 mg, 250-Count, with regard to male fertility & your own reproductive system program: Lots of people take advantage of zinc regarding safe prostatic hyperplasia (BPH), guy infertile, hard-on disorder (ED), delicate navicular bone (osteoporosis), rheumatoid arthritis symptoms signs and symptoms, in addition to muscle tissue cramps asso

Choosing protein bars for weight loss have to be done now what are the benefits of protein bars and how to choose best proteins bars which contain mostly natural ingredients & minimum additives & preservatives.The market today is flooded today with several bars carrying the tag of 'protein bars' but in actuality they are loaded with refined sugars & harmful fats. Also, several protein bars which do contain good amount of proteins are often not chosen by consumers since they taste quite bland.

FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 60 Days Money Back Guarantee FitSpresso Herpesyl Five Star FitSpresso is a supplement made to help people lose weight naturally. This supplement comes in the form of veggie capsules, and it is designed to boost metabolism, promote weight loss, burn fat, slow down weight gain, and destroy fat cells. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What Is FitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with insulin re

Saraswathi Eye Hospital Madurai is one of the top eye hospital in India, specialised in Myopia or Nearsightedness. The top eye care center offers treatment for eye blurring, retinal degeneration, vision blurring, short-sightedness, high myopia, myopia hyperopia, severe myopia, myopia in children and vision therapy

One thing that can be counted on when you workout or exercise is getting warmer. The whole idea is to increase your heart rate and tone the muscles and this is going to make you get hotter and perspire - perspiration is the body's natural way of keeping cool. However after your workout, it is important to stay warm for several reasons.

One thing that can be counted on when you workout or exercise is getting warmer. The whole idea is to increase your heart rate and tone the muscles and this is going to make you get hotter and perspire - perspiration is the body's natural way of keeping cool. However after your workout, it is important to stay warm for several reasons.