Acute vitamin D intoxication in a child.
Barrueto F Jr, Wang-Flores HH, Howland MA, Hoffman RS, Nelson LS.
Pediatrics. 2005 Sep;116(3):e453-6.
PMID: 16140692
Unusually prolonged vitamin D intoxication after discontinuation of vitamin D: possible role of primary hyperparathyroidism.
Taskapan H, Vieth R, Oreopoulos DG.
Int Urol Nephrol. 2008;40(3):801-5. Epub 2008 Jun 5.
PMID: 18528779
DOI: 10.1007/s11255-008-9404-1
"I know what you may be thinking: "Fish oil?! I thought fish oil was supposed to be healthy! One day you say we should take it, now you're saying it puts us at risk for Swine Flu?" Well, there is a reasonable answer, but it doesn't come in the form of a simple "fish oil is good" or "fish oil is bad" kind of package. The truth is that eating fish and taking fish oil is very often extremely beneficial for a great number of health conditions. But there is no substance on Earth that is 100% healthy under every conceivable circumstance. Take water, for example. Drinking plenty of pure water is a healthful practice. On the other hand, drinking excessive amounts (water intoxication) can lead to serious bodily damage and even death.
The August issue of the Journal of Nutrition reports on a study conducted on two groups of mice fed either a fish oil or corn oil enriched diet. (4) All the mice were infected with the flu virus and were then examined over a two week period. Several interesting observations were made at the conclusion of the trial:
* The mice receiving the fish oil exhibited lower levels of lung tissue inflammation. This confirms the known anti-inflammatory activity of omega-3 fatty acids found in fish.
* However, these same mice suffered a "40% higher mortality rate", a "70% higher lung viral load" and "a prolonged recovery period following infection".
* The researchers also noted a decline in NK (natural killer) cells in the spleens of the mice that were fed fish oil and a decrease in CD8+ T cells. NK cells and cytotoxic T cells are vital players in the body's ability to deal with infections."
Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity.
Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP.
Ann Intern Med. 1995 Apr 1;122(7):511-3.
PMID: 7872586
CONCLUSIONS: Although the patients had normal or near-normal total 1,25-(OH)2D values, most patients had elevated free 1,25-(OH)2D levels. These findings suggest that elevated free 1,25-(OH)2D levels might play a role in the pathogenesis of hypercalcemia in vitamin D toxicity.
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy.
Blank S, Scanlon KS, Sinks TH, Lett S, Falk H.
Am J Public Health. 1995 May;85(5):656-9.
PMID: 7733425