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Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volum... - 0 views

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    Vitamin D, nervous system and aging. P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. . Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286 NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION doi:10.1016/j.psyneuen.2009.07.003 This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Matti Narkia

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostat... - 0 views

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    Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects o
Matti Narkia

Melanoma growth is reduced in fat-1 transgenic mice: Impact of omega-6/omega-3 essentia... - 0 views

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    Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12499-504. Epub 2006 Aug 3. PMID: 16888035 doi: 10.1073/pnas.0605394103 In vitro experiments showed that addition of the n-3 fatty acid eicosapentaenoic acid or PGE(3) inhibited the growth of B16 cell line and increased the expression of PTEN, which could be partially attenuated by inhibition of PGE(3) production, suggesting that PGE(3) may act as an antitumor mediator. These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3).
Matti Narkia

New endogenous anti-inflammatory and proresolving lipid mediators: implications for rhe... - 0 views

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    New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Yacoubian S, Serhan CN. Nat Clin Pract Rheumatol. 2007 Oct;3(10):570-9; quiz 1 p following 589. Review. PMID: 17906612
Matti Narkia

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators : Abs... - 0 views

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    Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294
Matti Narkia

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic gen... - 0 views

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    Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Serhan CN, Chiang N. Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15. Epub 2007 Oct 29. Review. PMID: 17965751 DOI: 10.1038/sj.bjp.0707489
Matti Narkia

Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory... - 0 views

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    Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. Serhan CN. J Periodontol. 2008 Aug;79(8 Suppl):1520-6. Review. PMID: 18673006 doi:10.1902/jop.2008.080231
Matti Narkia

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. - Science... - 0 views

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    Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Serhan CN. Pharmacol Ther. 2005 Jan;105(1):7-21. Review. PMID: 15626453 doi:10.1016/j.pharmthera.2004.09.002
Matti Narkia

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflam... - 0 views

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    The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Arita M, Clish CB, Serhan CN. Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. Epub 2005 Aug 10. Review. PMID: 16112645 doi:10.1016/j.bbrc.2005.07.181    
Matti Narkia

RvE1 protects from local inflammation and osteoclast-mediated bone destruction in perio... - 0 views

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    RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. FASEB J. 2006 Feb;20(2):401-3. Epub 2005 Dec 22. PMID: 16373400 doi:10.1096/fj.05-4724fje
Matti Narkia

Novel chemical mediators in the resolution of inflammation: resolvins and protectins. -... - 0 views

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    Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Serhan CN. Anesthesiol Clin. 2006 Jun;24(2):341-64. Review. PMID: 16927933
Matti Narkia

Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectin... - 0 views

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    Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Serhan CN. Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):115-21. Review. PMID: 15716788
Matti Narkia

Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a rando... - 0 views

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    Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15178-83. Epub 2004 Oct 7. PMID: 15471991 doi: 10.1073/pnas.0405445101
Matti Narkia

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal d... - 0 views

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    Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti J. J Exp Med. 2008 May 12;205(5):1077-86. Epub 2008 Apr 14. PMID: 18411340 doi:10.1084/jem.20072416
Matti Narkia

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 depend... - 0 views

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    Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J. Nat Med. 2006 Mar;12(3):330-4. Epub 2006 Jan 15. PMID: 16415877 doi:10.1038/nm1355\n
Matti Narkia

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiat... - 0 views

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    An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko R. Br J Pharmacol. 2008 Dec;155(8):1214-23. Epub 2008 Sep 22. PMID: 18806821
Matti Narkia

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in r... - 0 views

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    Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN. J Immunol. 2008 Dec 15;181(12):8677-87. PMID: 19050288
Matti Narkia

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving acti... - 0 views

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    Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. J Exp Med. 2009 Jan 16;206(1):15-23. Epub 2008 Dec 22. PMID: 19103881 doi:10.1084/jem.20081880
Matti Narkia

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic gen... - 0 views

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    Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Serhan CN, Chiang N. Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15. Epub 2007 Oct 29. Review. PMID: 17965751 doi:10.1038/sj.bjp.0707489
Matti Narkia

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis ... - 0 views

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    Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. Hong S, Lu Y, Yang R, Gotlinger KH, Petasis NA, Serhan CN. J Am Soc Mass Spectrom. 2007 Jan;18(1):128-44. Epub 2006 Oct 19. PMID: 17055291 doi:10.1016/j.jasms.2006.09.002    
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