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Matti Narkia

Spices halt growth of breast stem cells, U-M study finds - 0 views

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    "ANN ARBOR, Mich. - A new study finds that compounds derived from the spices turmeric and pepper could help prevent breast cancer by limiting the growth of stem cells, the small number of cells that fuel a tumor's growth.

    Researchers at the University of Michigan Comprehensive Cancer Center have found that when the dietary compounds curcumin, which is derived from the Indian spice turmeric, and piperine, derived from black peppers, were applied to breast cells in culture, they decreased the number of stem cells while having no effect on normal differentiated cells.

    "If we can limit the number of stem cells, we can limit the number of cells with potential to form tumors," says lead author Madhuri Kakarala, M.D., Ph.D., R.D., clinical lecturer in internal medicine at the U-M Medical School and a research investigator at the VA Ann Arbor Healthcare System."
Matti Narkia

Synergistic anti-inflammatory effects of low doses of curcumin in combination with poly... - 0 views

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    Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid.
    Saw CL, Huang Y, Kong AN.
    Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8.
    PMID: 19744468
Matti Narkia

Dietary Curcumin and Limonin Suppress CD4+ T-Cell Proliferation and Interleukin-2 Produ... - 0 views

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    These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4+ T-cell-mediated inflammation.D

    ietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice.
    Kim W, Fan YY, Smith R, Patil B, Jayaprakasha GK, McMurray DN, Chapkin RS.
    J Nutr. 2009 May;139(5):1042-8. Epub 2009 Mar 25.
    PMID: 19321585
    doi:10.3945/jn.108.102772
Matti Narkia

Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 f... - 0 views

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    Mice fed fish oil and curcumin showed a significantly reduced tumor volume, 25% (P < 0.04) and 43% (P < 0.005), respectively, and importantly, a combination of curcumin and fish oil diet showed > 72% (P < 0.0001) tumor volume reduction. Expression and activity of iNOS, COX-2, and 5-LOX are downregulated, and p21 is upregulated in tumor xenograft fed curcumin combined with fish oil diet when compared to individual diets. The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties.

    Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.
    Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, Rao CV.
    Nutr Cancer. 2008;60 Suppl 1:81-9.
    PMID: 19003584
Matti Narkia

Weekly curry 'may fight dementia' - BBC NEWS | Health - 0 views

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    Eating a curry once or twice a week could help prevent the onset of Alzheimer's disease and dementia, a US researcher suggests.
    The key ingredient is curcumin, a component of the spice turmeric.
Matti Narkia

'Holy powder' ingredient makes membranes behave for better health - 0 views

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    ANN ARBOR, Mich.---Revered in India as "holy powder," the marigold-colored spice known as turmeric has been used for centuries to treat wounds, infections and other health problems. In recent years, research into the healing powers of turmeric's main ingredient, curcumin, has burgeoned, as its astonishing array of antioxidant, anti-cancer, antibiotic, antiviral and other properties has been revealed.\n\nYet little has been known about exactly how curcumin works inside the body.\n\nNow, University of Michigan researchers led by Ayyalusamy Ramamoorthy have discovered that curcumin acts as a disciplinarian, inserting itself into cell membranes and making them more orderly, a move that improves cells' resistance to infection and malignancy
Matti Narkia

Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Sp... - 0 views

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    Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin.
    Barry J, Fritz M, Brender JR, Smith PE, Lee DK, Ramamoorthy A.
    J Am Chem Soc. 2009 Mar 3. [Epub ahead of print]\nPMID: 19256547
    DOI: 10.1021/ja809217u
Matti Narkia

Intelligent eating | Food for thought | The Economist - 0 views

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    CHILDREN have a lot to contend with these days, not least a tendency for their pushy parents to force-feed them omega-3 oils at every opportunity. These are supposed to make children brainier, so they are being added to everything from bread, milk and pasta to baby formula and vitamin tablets. But omega-3 is just the tip of the nutritional iceberg; many nutrients have proven cognitive effects, and do so throughout a person's life, not merely when he is a child.\n\nFernando Gómez-Pinilla, a fish-loving professor of neurosurgery and physiological science at the University of California, Los Angeles, believes that appropriate changes to a person's diet can enhance his cognitive abilities, protect his brain from damage and counteract the effects of ageing
Matti Narkia

Science & Technology at Scientific American.com: Spice Healer -- [ INNOVATIONS ] -- An ... - 0 views

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    Spice Healer
    An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases
    By Gary Stix.
    Scientific American, February 2007.
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