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The Core Java technologies and application programming interfaces (APIs) are the foundation of the Java Platform, Standard Edition (Java SE). They are used in all classes of Java programming, from desktop applications to Java EE applications. Learn Java and core Java online to get good opportunities.

Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun;9(2):136-56. Review. PMID: 15253675 [PubMed - indexed for MEDLINE]

Vitamin D status: measurement, interpretation, and clinical application. Holick MF. Ann Epidemiol. 2009 Feb;19(2):73-8. Epub 2008 Mar 10. Review. PMID: 18329892 Conclusion The only way to determine whether a person is vitamin D deficient or sufficient is to measure their circulating level of 25(OH)D. There are a variety of assays used to measure 25(OH)D. The radioimmunoassays and competitive protein binding assays for 25(OH)D are useful in detecting vitamin D deficiency and sufficiency. However, these assays are fraught with technical difficulties, especially if they are not run routinely (Fig. 4) (33). Several reference laboratories have now switched to LC-MS ,which measures both 25(OH)D2 and 25(OH)D3 quantitatively. The total 25(OH)D, i.e., 25(OH)D2 plus 25(OH)D3, is what physicians need to be aware of for their patients. A level >30 ng/mL is

Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator. Pereira CV, Machado NG, Oliveira PJ. Toxicol Sci. 2008 Oct;105(2):408-17. Epub 2008 Jul 3. PMID: 18599498 doi: 10.1124/jpet.107.128017 The data from the present work appear to show that berberine also presents some degree of toxicity to "nontumor" systems, which should be carefully understood. ANT inhibition in nontumor cells by berberine would be responsible for a decrease in energy production and could also result in MPT induction. To the best of our knowledge, no full toxicity assessment exists for berberine in humans, although its use in several commercially available supplements suggests that the compound may present a relatively wide safety interval. In fact, a study with patients with congestive heart failure treated with 1.2 g/day of oral berberine revealed low toxicity and resulted into an average plasma concentration of 0.11 mg/l which would translate into 0.3µM (Zeng and Zeng, 1999Go). Repeated cumulative treatments, alternative forms of formulation (e.g., topical application vs. injection) or more importantly, active mitochondrial accumulation due to its positive charge would be expected to increase its concentration in cells into the range of concentrations used in this study. Empirical data from nontraditional medicines plus the use of extensive clinical assays would allow the use of berberine as a promising antimelanoma agent while maintaining its safety for humans. In radial/vertical forms of melanoma, a possible topical application of berberine would also be possible, thus minimizing side effects on other organs. In conclusion, the present work identifies the ANT as an important target for berberine, with clear relevance for its proposed antitumor effects.

Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity. Lachenmeier DW. J Occup Med Toxicol. 2008 Nov 13;3:26. PMID: 19014531 doi:10.1186/1745-6673-3-26

The application of probiotics in cancer. de Moreno de LeBlanc A, Matar C, Perdigón G. Br J Nutr. 2007 Oct;98 Suppl 1:S105-10. Review. PMID: 17922945 doi:10.1017/S0007114507839602

Explain all your money related inconveniences by depending on short term loans, which let you acquire any sum as high as CAD$1000. On account of the online application handle, you can apply for these advances through web, without leaving the solace of your home.

Egg fortification with n-3 polyunsaturated fatty acids (PUFA): nutritional benefits versus high n-6 PUFA western diets, and consumer acceptance. Shapira N, Weill P, Loewenbach R. Isr Med Assoc J. 2008 Apr;10(4):262-5. PMID: 18548978 Egg fortification with n-3 polyunsaturated fatty acids (PUFA): nutritional benefits versus high n-6 PUFA western diets, and consumer acceptance. Shapira N, Weill P, Loewenbach R. Isr Med Assoc J. 2008 Apr;10(4):262-5. PMID: 18548978 CONCLUSIONS: Effective concentration and transformation of supplemental n-3 PUFA/LCPUFA from feed to egg substantially enhanced egg n-3 PUFA %DRI, particularly of DHA, critical for health but often deficient. Such land-based n-3 PUFA/LCPUFA fortification may be applicable to high n-6 PUFA diets, fitting within cholesterol limitations and market criteria. It may contribute to general health and specific requirements (i.e., pregnancy and lactation), with possibilities of wide accessibility and standardization.

A high quality education doesn't have to come at a high cost. In fact, it's possible to take classes from big names like Yale, MIT, and Tufts without ever submitting an application or paying a cent in tuition. We've compiled 200 online classes from these and other respected institutions, and you can take all of them with no strings attached.

"Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm (Cocos nucifera). Throughout the tropical world it has provided the primary source of fat in the diets of millions of people for generations. It has various applications in food, medicine, and industry. What makes coconut oil different from most other dietary oils is the basic building blocks or fatty acids making up the oil. Coconut oil is composed predominately of a special group of fat molecules known as medium chain fatty acids (MCFA). The majority of fats in the human diet are composed almost entirely of long chain fatty acids (LCFA). The primary difference between MCFA and LCFA is the size of the molecule, or more precisely, the length of the carbon chain that makes up the backbone of the fatty acid. MCFA have a chain length of 6 to 12 carbons. LCFA contain 14 or more carbon Historically, many populations within the tropics have used coconut medicinally as a treatment for a wide variety of ailments.[8] A study into the effects of a "diet rich in.." medium-chain fatty acids (such as in coconut oil and butter) concluded that "MCFAs in the form of MCTs significantly increased plasma triacylglycerol and LDL-cholesterol concentrations and the ratio of LDL to HDL cholesterol and thereby resulted in a less beneficial lipid profile overall."[9] Further, research done by nutritionist Mary Enig has found that non-hydrogenated coconut oil (i.e. extra-virgin) consumed in moderate amounts "is at worst neutral with respect to atherogenicity of fats and oils and, in fact, is likely to be a beneficial oil for prevention and treatment of some heart disease."[10] The lack of negative effects of a diet rich in coconut oil on cardiovascular health is born out in studies of Polynesian populations who consume as much as 65% of their calories in the form of coconut oil and yet, have almost no incidence of heart disease and normal blood lipid profiles.[11]

Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review1,3. Hunter JE, Zhang J, Kris-Etherton PM. Am J Clin Nutr. 2009 Nov 25. [Epub ahead of print] PMID: 19939984 doi:10.3945/ajcn.2009.27661 Conclusions: TFA intake should be reduced as much as possible because of its adverse effects on lipids and lipoproteins. The replacement of TFA with STA compared with other saturated fatty acids in foods that require solid fats beneficially affects LDL cholesterol, the primary target for CVD risk reduction; unsaturated fats are preferred for liquid fat applications. Research is needed to evaluate the effects of STA on emerging CVD risk markers such as fibrinogen and to understand the responses in different populations.

"The affirmation that the omega-3 DHA can benefit cognitive and eye health offers hope to previously rejected claims. And it's business as usual regarding the overall health claims process, despite ratification of the Lisbon Treaty, said a European Commission representative. At the NutraIngredients Health Claims 2010 conference in Brussels, the EC's Lars Korsholm explained the regulatory state-of-play for DHA claims. "I think it will offer some hope to previously rejected claims in the sense that these claims that are now subject for discussion are generic in the sense that if other food business operators than those who actually submitted the application can claim to fulfill the conditions of use then they are equally entitled to use the claim," explains Korsholm. The statements come in relation to an October decision whereby the European Food Safety Authority (EFSA) affirmed that the omega-3 fatty acids, DHA and ALA, can benefit eye and cognitive development in babies. Responding to the public comment period for Merck Selbstmedikation GmbH's article 14 cognitive development claim that was rejected in March, EFSA affirmed its original stance that there was no need for additional supplementation of DHA (docosahexaenoic acid) and ALA (alpha-linolenic acid) because it already existed at adequate levels in the diet. It supported their role in foetal and newborn eye and brain development but said there was an adequate supply in breast milk. "

The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Gombart AF. Future Microbiol. 2009 Nov;4:1151-65. PMID: 19895218 Vitamin D deficiency has been correlated with increased rates of infection. Since the early 19th century, both environmental (i.e., sunlight) and dietary sources (cod liver) of vitamin D have been identified as treatments for TB. The recent discovery that vitamin D induces antimicrobial peptide gene expression explains, in part, the 'antibiotic' effect of vitamin D and has greatly renewed interest in the ability of vitamin D to improve immune function. Subsequent work indicates that this regulation is biologically important for the response of the innate immune system to wounds and infection and that deficiency may lead to suboptimal responses toward bacterial and viral infections. The regulation of the cathelicidin antimicrobial peptide gene is a human/primate-specific adaptation and is not conserved in other mammals. The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems. Future studies in both humans and humanized mouse models will elucidate the importance of this regulation and lead to the development of potential therapeutic applications

"Peter at Hyperlipid and Stephan at Whole Health have dispelled yet again myths regarding the indictment of the 16:0 long-chained saturated fatty acid Palmitic Acid as the prime instigator of insulin resistance (IR). Researchers are always wrong -- it's... HIGH CARBS PLUS Palmitic acid. Their brilliant posts discuss below: --Sportzaid (FRUCTOSE) + Palmitate = IR RETARDNESS --High Carb Lab Chow + Palmitate = IR in the brain Yes. Such inferences applied to low carbers (LCers) is pure ridiculousness. Non-applicable. Low/no carb + Palmitic Acid = GOOD THING. All the low-carb/high saturated fat (palmitic acid) and ketosis trials by Hays JH, Volek JS, and Krauss RM have shown reductions in blood insulin, blood glucoses (BG) and peripheral tissue insulin resistance (IR). Directly contrary to the high carb animal or human studies. Palmitic acid has a special evolutionary, adaptive role in mammalian metabolism. Stephan showed that it likely 'fills in' when blood glucose starts to decline. "

Metabolic effects of conjugated linoleic acid in humans: the Swedish experience. Riserus U, Smedman A, Basu S, Vessby B. Am J Clin Nutr. 2004 Jun;79(6 Suppl):1146S-1148S. PMID: 15159248 CONCLUSIONS CLA and specifically the isolated isomers are interesting model fatty acids for studies of the effects of (structural differences of) unsaturated fatty acids in humans. Today, there is no clear indication for human use of CLA concentrates. The possible importance of the small reduction of body fat after supplementation with the commercially available CLA products, without evidence of an associated improvement in the metabolic profile, has to be weighed against the apparent reduction of HDL cholesterol and an increased lipid peroxidation. The possible health consequences of prolonged treatment periods are at present unknown. Human supplementation with high doses of the trans-10,cis-12 CLA isomer should be avoided while awaiting further information on possible effects and side effects. However, it cannot be excluded that future studies could point to clinical applications, eg, as a result of antitumorigenic properties or as a tool to prevent weight gain. This possibility certainly requires more research to increase the understanding of the mechanisms behind the effects of CLA and specific CLA isomers on a molecular level. More controlled studies in defined populations are needed, as are controlled studies for comparisons of the effects of different and well-defined (mixtures of) isomers and human studies of longer duration to secure long-term effects and safety.

Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. J Ethnopharmacol. 2009 Oct 29;126(1):5-17. Epub 2009 Aug 15. PMID: 19686830 doi:10.1016/j.jep.2009.08.009 Conclusions The modern evidences of treating cancer with Huanglian and berberine have a strong linkage with traditional concept and rules of using Huanglian in CM practice. As anticancer candidates with low toxicity, berberine and its altered structure, as well as Huanglian and its formulae, will attract scientists to pursue the potential anticancer effects and the mechanisms by using technologies of genomics, proteomics and other advanced approaches. On the other hand, relatively few in vivo studies have been conducted on anticancer effects of Huanglian and berberine. The clinical application of berberine or Huanglian as novel cancer therapeutic agents requires in vivo validations and further investigations of their anticancer mechanisms.

Hundreds of miraculous health benefits are associated with the consumption of lemon juice. In this article, I have elaborated on the top ten amongst all the lemon juice benefits. Lemon enjoys a global eminence, thanks to its incredible health benefits. Several advantages are also associated with the consumption of this tangy juice. Scroll down and enjoy the read. Lemon Juice: Prevents Cancer Lemon is well-known for its richness in multipurpose flavonoid compounds which defend your body against different types of cancer. Thus, regular consumption of lemon juice ensures the prevention of cancerous cells. Lemon Juice: Treat the Upset Stomach Lemon juice is a marvellous drink for people who are suffering from an upset stomach. Digestive problems like diarrhoea or constipation make you feel uncomfortable in addition to botching up your daily routine. To deal with such problems, intake one glass lemon water at the start of the new day. You can maximize the benefits by adding one teaspoon of honey to this solution. Lemon Juice: Good for Liver One of the main advantages of lemon juice is its assistance in improving the liver function and flushing out the toxins from the body. This zesty fruit increase the production of bile in the body that is required for breaking down the fats and lipids. Lemon Juice: Assists in dealing with infections Lemons contain a high amount of Vitamin C, which is essential for strengthening the immune system. So, consuming it in any form is a natural way to prevent viral infections like cold and flu. Lemon water also aids in treating urinary tract infections. Lemon Juice: Best for Hypertension Patients People, who don't consume sufficient amount of potassium, are at higher risks of getting affected by cardiological disorders. Lemon juice contains a satisfactory amount of potassium, so it can help in reducing the risks of such problems. Lemon Juice: Acts as Natural Cleanser for Skin The cleansing properties of lemon juice

Lemon comes from an evergreen tree originally found in Asia. The fruit is usually greenish or yellow in colour. The whole fruit with its pulp, the juice, the rind and the zest are used in cooking as well as non-culinary purposes. Lemon juice is often used to make lemonade and other lemon beverages. The juice contains 6% citric acid which makes its taste sour. It contains vitamin c, calcium, folate, vitamin b5, vitamin b3, vitamin b1 and b2, iron, magnesium, phosphors, potassium, zinc as well as sugar, carbohydrates, dietary fiber, fat and protein. Here is an exhaustive list of the health benefits of lemon: Body skin loses moisture when in contact with chlorinated water at the time of bathing. Use lemon along with turmeric and starch as a cleanser before bath. Take 4 tablespoons of yogurt and 3 teaspoons of lemon juice and mix them well. Add 1 teaspoon of vegetable oil (any variant) to it and massage this pack on body using upward strokes and leave it for 10-15 minutes. Then wash off and take your usual bath. lemon oil benefits for hair Mix 2 tablespoons of lemon juice, 2 tablespoons tomato juice and 2 tablespoons milk in a bowl and apply it on the face and body. This mixture works as natural bleach. lemon face benefits for oily skin Lemon juice can help relieve you from wrinkles. To make the anti-wrinkle mask, use a tablespoon of honey and add some drops of lemon juice to it. Also add a few drops of almond oil (sweet) to this and mix the ingredients into a paste. Then use this on the face and keep it on for 15-20 minutes and then wash off. Lemon also helps to relieve chapped lips. Mix a teaspoon of fresh cream, a teaspoon of lemon juice and a teaspoon of honey and make this into a paste. Use this on the lips and rub it in. Store the rest and use for a week to see results. Lemon can be used to make your hands and body skin younger and beautiful. To make this application you will need the juice of a lime (freshly squeezed), a teas

Weight gain: Mango Juice is highly beneficial in gaining weight because of the presence of adequate amount of protein both in milk and mango. The underweight people can drink mango juice regularly during summer. 150 grams of mango has about 86 calories, and starch easily converts into sugar thereby helps in weight gain. This is the most important health benefits of mango juice. However, obese person should avoid drinking of mango Juice. Good for anemia patient: The mango Juice is the most delicious juice and filled with important nutrients like iron, protein and beta-carotene. It is good for anemia patient and those have protein deficiency. One of the important benefits of mango juice is to increase red blood cells count in the body. Mango juice also has significant amount of iron. Regular drinking of one glass of mango juice is enough to provide necessary amount of iron to the body. Mango juice is also beneficial for pregnant mother as far as iron content is concern. A number of studies have shown that iron content is beneficial in reduction of muscle cramp, anxiety, stress and heart related problems. Good for eyes: Mango contains vitamin A, which is beneficial for eyes and skin. The sufficient amount of vitamin A helps the eyes against dryness, night blindness along with facilitating good eye sight. Strengthen bones: Milk, which is the integral part of mango juice, is having vitamin D and calcium, helps in strengthening of bones. Maintains blood pressure: Mango juice is rich in potassium and magnesium, which helps to keep blood pressure under control. Potassium assists the heart and regulates blood pressure as well as balance fluids in your body. Mango juice also lowers blood pressure due to tinnginya fiber, pectin and vitamin C. Pectin and vitamin C reduces the serum cholesterol levels, especially the low-density lipoprotein For heart health: Mango in Mango Drinks has high amount of pectin, a dietary fiber and helpful in lowering cholesterol

The healthcare technology industry is no different from other industries in having fashion and trends. Two years ago, PHR (Personal Health Records) systems were fashionable and today they're not - probably because the business model for PHR applications is unclear and unproven. Today - social networking for healthcare is hot and I'm confident that once the market shakes out the buzz words from the business, we'll see social software playing a big part in revolutionizing healthcare with vastly more effective doctor-patient communications and collaboration, improved outcomes, better compliance and better patient education.