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Nathan Goodyear

Vitamin D for Cancer Prevention: Global Perspective - 0 views

www.sciencedirect.com/...S1047279709001057

vitamin D vitamin d cancer

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Only abstract available here.  The authors of the this epidemiologic article estimate that 58,000 cases of breast cancer and 49,000 cases of colorectal cancer can be prevented annually by raising levels to 40-60.  The study also points to a new cancer model that Vitamin D has a positive effect at each step.  The acronym is DINOMIT and this stands for disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition.
Nathan Goodyear

Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast C... - 0 views

ar.iiarjournals.org/...1163.long

Vitamin D vitamin D cancer breast cancer survival inflammation

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Higher serum 25(OH)D concentrations were associated with lower fatality rates in patients with breast cancer
  • Patients with the highest concentration of 25(OH)D had approximately half the fatality rate compared to those with the lowest concentration
  • According to this hypothesis, the growth of a tumor may be arrested at almost any point in the DINOMIT model by restoring a high serum 25(OH)D concentration in the organism, resulting in up-regulation of E-cadherin and restoration of a well-differentiated state
  • ...1 more annotation...
  • Laboratory studies have demonstrated anticancer effects of vitamin D metabolites on three critical phases in the development of breast tumors: differentiation, apoptosis, and angiogenesis
  • Nathan Goodyear on 17 Sep 14
     
    Higher vitamin D levels associated with lower death rates from breast cancer.  In fact, people with the highest levels of vitamin D had death rates cut in half.  The authors point to 3 ares that vitamin D has a positive effect against cancer: differentiation, apoptosis, and angiogenesis.
Nathan Goodyear

Use of Aromatase Inhibitors in Large... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25226294

aromatase aromatase inhibition aromatase inhibitor Man Boobs gynecomastia male hormones

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  • Nathan Goodyear on 17 Sep 14
     
    aromatase inhibition therapy shown to reduce and/or eliminate man boobs in young boys with sertoli cell tumors.
Nathan Goodyear

Diet-induced obesity and low testosteron... [J Neuroinflammation. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25224590

low T low Testosterone low T men male hormones hormone Testosterone diet indued obesity DIO alzheimer's disease diabetes obesity inflammation

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    animal model finds that low Testosterone and diet induced obesity leads to neuroinflammation and increased risk of Diabetes and Alzheimer's disease.
Nathan Goodyear

Therapeutic potentials of combined use of DMSA wit... [Biometals. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17287888

DMSA Pb lead vitamin C vitamin C

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Study of mice finds DMSA with calcium plus vitamin C chelates/mobilized Pb.
Nathan Goodyear

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1700586/pdf/brmedj02278-0080b.pdf - 0 views

www.ncbi.nlm.nih.gov/...brmedj02278-0080b.pdf

pesticide pesticides ED men male

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    case study from years ago that finds pesticide exposure caused impotence in 4 agriculture workers.  
Nathan Goodyear

Environmental Agents and Erectile Dysfunction: A Study in a Consulting Population - OLI... - 0 views

onlinelibrary.wiley.com/...abstract

ED erectile dysfunction environmental toxins environment pesticides solvents

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Environmental toxins (pesticides, solvents shown to be associated increased odds ratio for ED.
Nathan Goodyear

Environmental Erectile Dysfunction: Can the Environment Really Be Hazardous to Your Ere... - 0 views

onlinelibrary.wiley.com/...full

ED erectile dysfunction environment health

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    nice review of the link between environment and ED in men.  No direct cause-effect, but association is definitely seen.
Nathan Goodyear

http://benthamopen.com/toandroj/articles/V003/6TOANDROJ.pdf - 0 views

benthamopen.com/...6TOANDROJ.pdf

ED erectile dysfunction Pb lead

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Case study of Pb induced neurogenic ED.
Nathan Goodyear

Erectile dysfunction and depression in patients with chronic lead poisoning - Gonulalan... - 0 views

onlinelibrary.wiley.com/...abstract

Pb lead erectile dysfunction

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Another study links ED to Pb.
Nathan Goodyear

Lead acetate may cause erectile dysfunctio... [Cell Biol Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23979109

ED erectile dysfunction NO Pb lead

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    In rat model, Pb reduced NO and contributed to ED.  Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.
Nathan Goodyear

Chronic lead exposure may be associated with erect... [J Sex Med. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17727353

lead Pb exposure ED CVD men male infertility erectile dysfunction

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    chronic lead exposure associated with ED in men.  As lead is a contributor to CVD, logically, this is not a surprise.
Nathan Goodyear

Catcholamine and nitric oxide systems as targets of... [Life Sci. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11205890

Pb lead NO catecholamines epinephrine norepinephrine hypertension CVD cardiovascular disease

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb reduced NO, increased epinephrine and norepinephrine, increased vascular resistance and RAA system which resulted in hypertension.
Nathan Goodyear

Lead-induced hypertension: possible role of e... [Am J Hypertens. 1993] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8110424

lead Pb hypertension CVD cardiovascular disease

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Low lead exposure causes vasoconstriction in animal study.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15721881

Pb lead SOD CAT GPX detoxification superoxide disumutase catalase glutathione glutathione peroxidase

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb induces dysfunction of SOD, CAT, and GPX.
Nathan Goodyear

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks - 0 views

hyper.ahajournals.org/...463.long

Pb lead hypertension CVD cardiovascular disease heart health

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Lead is associated with elevated blood pressure in black people, though no association is found in white people.
Nathan Goodyear

Blood lead levels and mortality. [Arch Intern Med. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12437403

Pb lead cardiovascular disease CVD heart health mortality

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Lead exposure associated with increased cardiovascular disease and mortality.
Nathan Goodyear

Kininergic system and arterial hypertensi... [Immunopharmacology. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10604532

Pb lead hypertension cardiovascular disease CVD

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Animal model finds that Pb induces hypertension at levels similar to general population exposures.
Nathan Goodyear

Cyclooxygenase inhibition reduces blood p... [Clin Exp Hypertens. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10744360

cyclooxygenase NO Hg mercury heart health COX cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.
Nathan Goodyear

Endothelial dysfunction of rat coronary arteries after exposure to low concentrations o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3081124

Hg mercury NO cardiovascular disease heart health ROS reactive oxygen species oxidative stress

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    low dose, chronic exposure induces ROS and decreased NO availability.  This decrease in NO will result in increase vasoconstriction.  This will have localized effects and will result in increased central pressure as a result of the increased peripheral pressure.  In addition, inhibition of COMT will result in increase in catecholeamines.
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