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Nathan Goodyear

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer ... - 0 views

pubmed.ncbi.nlm.nih.gov/30688660

cancer stem cells breast cancer CSC LDH lactate dehydrogenase stress cancer epinephrine

shared by Nathan Goodyear on 22 Jul 22 - No Cached
  • Nathan Goodyear on 22 Jul 22
     
    Epinephrine increases LDH-A in breast cancer
Nathan Goodyear

Endocrine biomarkers and symptom clusters during t... [Menopause. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24781854

estrogen FSH epinephrine norepinephrine hot flashes women hormone hormones menopause cortisol Testosterone

shared by Nathan Goodyear on 07 May 14 - No Cached
  • Nathan Goodyear on 07 May 14
     
    Study finds that low estrogen, assuming estradiol, higher FSH, low epinephrine, higher norepinephrine are associated with severe hot flashes.  Of interesting note, Cortisol and Testosterone were not associated with symptom severity.
Nathan Goodyear

Catcholamine and nitric oxide systems as targets of... [Life Sci. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11205890

Pb lead NO catecholamines epinephrine norepinephrine hypertension CVD cardiovascular disease

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb reduced NO, increased epinephrine and norepinephrine, increased vascular resistance and RAA system which resulted in hypertension.
Nathan Goodyear

PsychiatryOnline | American Journal of Psychiatry | CSF Norepinephrine Concentrations i... - 0 views

ajp.psychiatryonline.org/article.aspx

CSF norepinephrine catecholamines PTSD plasma blood serum trauma stress psychiatry disorder

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    CSF norepinephrine levels found to be elevated in those with PTSD.  This is one of the few, if not only study, that has looked at epinephrine concentrations in PTSD.  Plasma norepinephrine levels were found to not be associated with PTSD.
Nathan Goodyear

Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acry... - 0 views

www.researchgate.net/...-induced_neurotoxicity_in_rats

RG3 panax ginseng neurotoxin brain acrylamide hormones

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    RG3, an extract from panax ginseng, found to protect against the neurotoxin acrylamide.   Also of interest, is that serotonin, corticosterone, T3, T4, estradiol, progesterone and epinephrine were all decreased in this acrylamide rat model.
Nathan Goodyear

Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans - 0 views

jpet.aspetjournals.org/...800.full

dopamine DOPAC catecholamines neurotransmitters epinephrine norepinephrine

shared by Nathan Goodyear on 21 Oct 15 - No Cached
  • Nathan Goodyear on 21 Oct 15
     
    Good review of the sources and metabolism of catecholamines in the blood.
Nathan Goodyear

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Ce... - 0 views

www.cell.com/...S1550-4131(16)30003-1

exercise cancer NK cells NK IL-6

shared by Nathan Goodyear on 11 Apr 16 - No Cached
  • Nathan Goodyear on 11 Apr 16
     
    Animal study finds that regular exercise reduces cancer cell growth through immune system activation. Also, regular exercise reduced the incidence of cancer in the mouse models.  
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buy adderall online at onlinemedzonline .com - 0 views

Adderall is a drug which is composed of two closely related components - amphetamine and dextroamphetamine. The drug mainly contains amphetamine in the percentage of 25% and dextroamphetamine in th...

health Disease hormones hormone cancer Testosterone Men inflammation obesity low Male

started by onlinemedzonline on 12 Mar 19 no follow-up yet
Nathan Goodyear

Cavernous and systemic plasma levels of norepinephrine and epinephrine during different... - 0 views

www.ncbi.nlm.nih.gov/...11834403

ED norepinephrine erectile dysfunction

shared by Nathan Goodyear on 22 May 17 - No Cached
  • Nathan Goodyear on 22 May 17
     
    elevated norepinephrine plays role in ED in men.
Nathan Goodyear

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil... - 0 views

www.nature.com/...s12276-022-00784-2

TME NETosis metastasis surgery cancer tumor microenvironment

shared by Nathan Goodyear on 20 Apr 23 - No Cached
  • tumor surgery must be carefully considered because the risk of metastasis could be increased by the surgical procedure.
  • NETosis, which is the process of forming neutrophil extracellular traps (NETs)
  • surgery-induced metastasis
  • ...61 more annotations...
  • surgery per se can promote cancer metastasis through a series of local and systemic events
  • surgery results in a serious wound that disrupts the structural barrier preventing the outspreading of cancer cells, change the properties of the cancer cells and stromal cells remaining in the tumor microenvironment, or impairs the host defense systems against cancers
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Key point; add to presentation on surgery and metastasis
  • After the primary tumor is surgically removed, the metastases can start to grow vigorously via neoangiogenesis because the circulating inhibitors disappear
  • infection and inflammation during the postoperative period have been reported to increase the risk of cancer recurrence in patients
  • Surgeons have long suspected that surgery, even if it is a necessary step in cancer treatment, facilitates cancer metastasis
  • Surgery-induced cancer metastasis has been well established in animal models
  • tumor cell dissemination, tumor-favoring immune responses, and neoangiogenesis
  • the surgical resection of primary tumors is beneficial is controversial
  • CTCs abruptly increase just after surgery
  • Even externally palpitating tumors for diagnosis could increase the numbers of CTCs in skin cancer and breast cancer
  • excessive glucocorticoids negatively modulate immune functions
  • immune surveillance against tumors is considered to be impaired by surgical stress
  • In addition to glucocorticoids, during stimulation of the HPA axis, the catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla
  • NK cell suppression may be attributed to increased levels of catecholamines as well as glucocorticoids
  • In mice bearing a primary tumor, it was observed that the removal of the primary tumor facilitated the growth of highly vascularized metastases
  • primary tumors may secrete angiogenic inhibitors as well as angiogenic activators
  • second phase of tumor recurrence and metastasis, which are newly acquired events, rather than just outcomes of incomplete treatment.
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Another key point
  • double-edged sword
  • HIF-1 in neutrophils plays a critical role in NETosis and bacteria-killing activity
  • neutrophils play various roles in the initiation and progression of cancer
  • NETosis
  • many inflammatory and neoplastic diseases
  • formation of neutrophil extracellular traps (NETs), which are large extracellular complexes composed of chromatin and cytoplasmic/granular proteins1
  • NETosis has been highlighted as an inflammatory event that promotes cancer metastasis
  • Once activated, neutrophils produce intracellular precursors by using DNA, histones, and granular and cytoplasmic proteins and then spread the mature form of NETs out around themselves
  • A series of these events is called NETosis.
  • neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, lactoferrin, gelatinase, lysozyme C, calprotectin, neutrophil defensins, and cathelicidins
  • innate immune response against infection
  • Neutrophils are the most abundant type of granulocytes, comprising 40–70% of all white blood cells
  • two types of NEToses, suicidal (or lytic) NETosis and vital NETosis
  • Suicidal NETosis mainly depends on the production of reactive oxygen species (ROS)
  • Since neutrophils die during this process, it is called suicidal NETosis.
  • vital NETosis
  • vital NETosis occurs independently of ROS production
  • Vital NETosis can be induced by Gram-negative bacteria. LPS
  • NETs are present in a variety of cancers, such as lung cancer, colon cancer, ovarian cancer, and leukemia
  • neutrophils actively undergo NETosis in the tumor microenvironment
  • Hypoxia
  • NETosis plays a pivotal role in noninfectious autoimmune diseases,
  • cytokines
  • tumor-derived proteases
  • tumor exosomes
  • NETosis generally actively progresses in the tumor microenvironment.
  • the proliferative cytokines TGFβ and IL-10 and the angiogenic factor VEGF are representative of neutrophil-derived tissue repair proteins.
  • NETosis is a defense system to protect the body from invading pathogens
  • when neutrophils are excessively stimulated, they produce excess NETs, thereby leading to pathological consequences
  • plasma levels of NETosis markers are elevated after major surgeries
  • local invasion, intravasation into the blood or lymphatic vessels, escape from the immune system, anchoring to capillaries in target organs, extravasation into the organs, transformation from dormant cells to proliferating cells, colonization to micrometastases, and growth to macrometastases
  • NETs promote metastasis at multiple steps
  • NETs loosen the ECM and capillary wall to promote the intravasation of cancer cells
  • NETs and platelets wrap CTCs, which protects them from attack by immune cells and shearing force by blood flow
  • NETs promote the local invasion of cancer cells by degrading the extracellular matrix (ECM)
  • neutrophil elastase, matrix metalloproteinase 9, and cathepsin G
  • NETs also promote the intravasation of cancer cells
  • millions of tumor cells are released into the circulation every day,
  • NETs can wrap up CTCs with platelets
  • β1-integrin plays an important role in the interaction between CTCs and NETs
  • NET-platelet-CTC aggregates.
  • After metastasizing to distant tissues, tumor cells are often found to remain dormant for a period of time and unexpectedly regrow late
  • NETs are believed to participate in the reactivation of dormant cancer cells in metastatic regions
  • NET-associated proteases NE and MMP-9 were found to be responsible for the reactivation of dormant cancer cells
  • Nathan Goodyear on 20 Apr 23
     
    Surgery induced metastasis: it is real and steered by NETosis.
Nathan Goodyear

Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with H... - 0 views

www.ncbi.nlm.nih.gov/...PMC3357525

prostate cancer IPTLD low-dose chemotherapy cancer chemotherapy insulin potentiation therapy LDMC low-dose metronomic chemotherapy IPT

shared by Nathan Goodyear on 25 Jan 18 - No Cached
  • The method of insulin potentiation therapy was empirically invented in 1930 from Mexican doctor D. Perez Garsia
  • increases the permeability of cell membrane
  • influences the metabolic processes in human body with the increase of the regenerating processes
  • ...9 more annotations...
  • facilitates the transport of intra and extra cellular liquids which helps the organism to eliminate the toxic products
  • The increased number of insulin receptors on the tumor cell, in comparison to the normal one, allows the before mentioned 2 factors to act predominantly
  • Increased permeability after the insulin effect on the cellular membrane results in increased intracellular quantity of antitumor agents
  • have other endocrine effects: directly stimulates suprarenal gland to produce epinephrine and glucocorticoid hormones and stimulates ACTH secretion. These endocrine effects also have a positive influence on the regenerating processes
  • Insulin influences the intracellular metabolism of the tumor cell, which leads to increase of the number of cells in phase S, where they are with highly sensitive to specific chemotherapeutics.
  • After the first 6 IPT applications overall (groups A and B) response to treatment on PSA criteria shows partial effect and stabilization in 12 of 16 (75%) patients
  • After the 10th IPTLD application or 3 months after starting treatment, complete response, partial response, and stabilization were observed in 4 of 9 (66.6%), while in 3 of 9 (33.3%) was registered complete effect
  • the advanced stage of disease in patients treated
  • Quality of life after the second IPTLD application is significantly improved
  • Nathan Goodyear on 25 Jan 18
     
    IPT found to be effextive in treated castrate-resistant prostate cancer.
Nathan Goodyear

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6391112

glycolytic shift LDH lactate dehydrogenase Stress immunosuppression Fear cancer

shared by Nathan Goodyear on 17 Apr 23 - No Cached
  • Nathan Goodyear on 17 Apr 23
     
    Mood, i.e., fear and stress push glycolytic shift and immunosuppression favoring carcinogenesis. Medicine must revisit how it approaches cancer diagnosis and movement forward. Propagation of fear only accelerates cancer progression.
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