Dr. Goodyear

Only abstract available here.  The authors of the this epidemiologic article estimate that 58,000 cases of breast cancer and 49,000 cases of colorectal cancer can be prevented annually by raising levels to 40-60.  The study also points to a new cancer model that Vitamin D has a positive effect at each step.  The acronym is DINOMIT and this stands for disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition.

Higher vitamin D levels associated with lower death rates from breast cancer.  In fact, people with the highest levels of vitamin D had death rates cut in half.  The authors point to 3 ares that vitamin D has a positive effect against cancer: differentiation, apoptosis, and angiogenesis.

aromatase inhibition therapy shown to reduce and/or eliminate man boobs in young boys with sertoli cell tumors.

animal model finds that low Testosterone and diet induced obesity leads to neuroinflammation and increased risk of Diabetes and Alzheimer's disease.

Study of mice finds DMSA with calcium plus vitamin C chelates/mobilized Pb.

case study from years ago that finds pesticide exposure caused impotence in 4 agriculture workers.  

Environmental toxins (pesticides, solvents shown to be associated increased odds ratio for ED.

nice review of the link between environment and ED in men.  No direct cause-effect, but association is definitely seen.

Case study of Pb induced neurogenic ED.

Another study links ED to Pb.

In rat model, Pb reduced NO and contributed to ED.  Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.

chronic lead exposure associated with ED in men.  As lead is a contributor to CVD, logically, this is not a surprise.

Pb reduced NO, increased epinephrine and norepinephrine, increased vascular resistance and RAA system which resulted in hypertension.

Low lead exposure causes vasoconstriction in animal study.

Pb induces dysfunction of SOD, CAT, and GPX.

Lead is associated with elevated blood pressure in black people, though no association is found in white people.

Lead exposure associated with increased cardiovascular disease and mortality.

Animal model finds that Pb induces hypertension at levels similar to general population exposures.

Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.

low dose, chronic exposure induces ROS and decreased NO availability.  This decrease in NO will result in increase vasoconstriction.  This will have localized effects and will result in increased central pressure as a result of the increased peripheral pressure.  In addition, inhibition of COMT will result in increase in catecholeamines.