Dr. Goodyear

This article finds the mean TSH level in the "healthy" population to be 1.5.  Calls into question any level above that with symptoms of hypothyroid.  Full, adequate thyroid including free T3 and rT3 must be done.

Case study highlighting the "false" elevations of glucose on strip testing with IV vitamin C.

Abstract only. Study in men seeking reproductive assistance found that increasing BMI had no negative impact on sperm concentration, sperm count, motility and seminal volume. 

Increased visceral adiposity results in increased 11beta-HSD that results in increased cortisone to cortisol production preference.  Cortisol production doesn't just come from the adrenals--it is also produced and metabolized in peripheral and visceral fat.

animal model finds that high fat diet induces ED more through increased Estradiol production than low Testosterone.  Of course the authors focused on the drugs to block E2 once produced, rather then reducing the T to E2 aromatase activity.  This metabolic syndrome model implies that increased aromatase activity will be present.

Study finds exercise useful as adjuvant to chemotherapy in the treatment of cancer.  The exercise consisted of 45 mins/day for 5 days. 

Three inflammatory biomarkers, TNF-alpha, CRP and IL-6 found to be associated with cancer.

No correlation between SCC, CEA and CYFRA 21-1 found in metastatic head and neck cancer.

Article looks at proposed 25 biomarkers to screen for Head and Neck squamous cancer.  Most of these could be used for all cancers as they are inflammatory cytokines.

Zinc carnosine found to aid gastric ulcer therapies.

case review of patient with elevated alkaline phosphatase. This case study includes a nice review of bile formation/function.

Gut to metabolic disease.

Gut microbiota effects insulin sensitivity.

metabolic endotoxemia leads to metabolic dysfunction and metabolic syndrome.

altered gut microbiota lead to systemic inflammation, obesity and diabetes.

Lead levels lead to increased risk of cardiovascular events at lower than previous thought levels.  Levels as low as 2mcg/dl found to be associated with increased cardiovascular mortality.  This equates to 38% of Americans.  The author concludes with this statement, "Although a 10-fold decline in blood lead levels has occurred in the United States in recent decades, current levels remain orders of magnitude higher than in pre industrialized times".

No amount of Pb level exposure is considered safe as levels as low as 3 mcg/dl has been shown to be associated with increased cardiac mortality.  This study found higher Pb levels in men versus women in Pakistan. This correlated with elevated homocysteine levels.  

Blood lead levels correlate with homocysteine levels.  Methylation (B12, Folate, B6) plays a role regulating homocysteine levels as well. 

Artificial sweeteners disrupt glucose metabolism through disruption of health gut bacteria balance.

Good review article of how vitamin D interacts with the biochemistry of breast cancer.