Dr. Goodyear

Weekly Testosterone injections increase type 1 slow muscle fibers more than type II fast twitch muscle fibers compared to monthly injections.  The study looked at older men with sarcopenia and low T.

Only abstract available here.  Race (black vs white) is associated with changes in obesity effects on adrogenicity, particularly in women.  One wonders if this is a result of other variables i.e.vitamin D.

small study finds limited improvement in cognition in men with low T and mild Cognitive impairment.  Little application from this study.

In some men, Testosterone therapy (10 mg transdermal) is associated with adipose tissue.  In those with a decrease in adipose tissue, a decrease in LDL, decrease in Triglycerides, increase in insulin sensitivity, and lower HDL were found.

Study looked at low T in men with type 1 Diabetes.  Only abstract available here.  Study finds appx 10% prevalence with age, waist circumference and insulin requirements as predictive of low T in men with type 1 Diabetes.

Radiation for prostate cancer associated with decline in serum Total Testosterone at 6 months, which resolved at 12 months.

New study finds "modest" association between Testosterone, DHEA, and FSH with libido, masturbation, and climax in women.  The author describes them as "subtle".  The association was not statistically significant.  The study found a great association with relationships than with Testosterone. This study points out the complexity that is libido in women.  It also casts doubt on the massive Testosterone push in women with little documented data.

Great review of thyroid metabolism.

startling obesity trends that don't show much sign of leveling off.

New study finds previous obesity data woefully underestimating rates.  This study finds that obesity rates exceed 35% in Mississippi and West Virginia.

Blood Sugar Log Booklet

Abstract: Inflammatory diesease (psoriasis and RA in this study) associated with increased cardiovascular events.

Dichloroacetate (DCA) inhibits aerobic glycolysis via inhibition of Pyruvate Dehydrogenase kinase (PDK), which allows for the phosphorylation of Pyruvate Dehydrogenase and the formation of acetylCo-A.  This then feeds the krebs cycle.  Increased mitochondrial activity increases ROS and resultant apoptosis of cancer cells.

DHEA proposed to be used to prevent/inhibit colorectal metastasis via inhibition of PRL-3 prenylation.

Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.

Study finds ER-beta plays more significant role in the development of Colon cancer than ER-alpha in women.  HRT in women reduces colon cancer risk in comparison to breast, which is increased.  Shows the different tissue expression of ER-alpha and ER-beta, as well as the HRT itself.

Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.

This article focus' more on the liver and insulin effect of DHEA, but highlights the 2002 study of DHEA and decreased aberrant crypt foci in potential cancer prevention.

Animal study suggests DHEA is preventative in colon cancer.

Study finds Testosterone induces apoptosis via deactivation of NGF.  Testosterone counters the proliferation of DHEA, via NGF activation.  Without evaluation of aromatase activity, this study is incomplete.