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Nathan Goodyear

A relationship in adrenal androgen levels between mothers and their children from a dioxin-exposed region in Vietnam - ScienceDirect - 0 views

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    Endocrine Disrupting Chemicals from 1970 still disrupting hormones today.  Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
Nathan Goodyear

Effect of meal fat content on salivary testosterone and cortisol levels in healthy female volunteers - 0 views

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    higher fat diet found to increase cortisol and Testosterone levels post meal in health women.  The effect was first seen early after lunch (30 minutes).
Nathan Goodyear

Sexual function and hormone profile in young adult men with idiopathic gynecomastia: Comparison with healthy controls. - PubMed - NCBI - 0 views

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    somewhat flawed study in that they looked at serum sex hormones to evaluate men with gynecomastia compared to controls.  A better eval would have been of saliva or blood spot.  Free levels will show more subtle changes physiologically than will serum as to the sex hormones.  The study did find decreased sexual function in the men with gynecomastia--indicating hormone issues not picked up by the serum.
Nathan Goodyear

Cortisol Measures Across the Weight Spectrum: The Journal of Clinical Endocrinology & Metabolism: Vol 100, No 9 - 0 views

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    Study looked at serum and salivary obesity in women: found that low cortisol was found in anorexia and class I obese women compared to normal weight women and that class II obesity was associated with hypercortisolism.
Nathan Goodyear

Cortisol Measures Across the Weight Spectrum: The Journal of Clinical Endocrinology & Metabolism: Vol 100, No 9 - 0 views

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    only abstract available.  elevated cortisol associated with the extremes: anorexia and severe obesity.  Mild obesity was associated with low cortisol.
Nathan Goodyear

http://www.biomedcentral.com/content/pdf/1756-0500-3-204.pdf - 0 views

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    salivary DHEA-S ranges from 4-10 ng/dl in men versus 1-5 in women with no variance between drool or cotton technique.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Receptor Gene Predict Amygdala Reactivity in Men - 0 views

  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
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    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Percutaneous progesterone delivery via cream or gel application in postmenopausal women: a randomized cross-over study of progesterone levels in serum, whole blood, saliva, and capillary blood. - 0 views

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    Topical hormones best evaluated via saliva and/or blood spot. Urine and particularly serum does not increase with dosing.  That does not mean the topical hormone therapy is ineffective, just that serum and urine are not optimal to follow topical therapy.  When looking at endogenous hormones without any therapies: serum, saliva, urine, and blood spot are equivalent.
Nathan Goodyear

http://download.springer.com/static/pdf/869/art%253A10.1007%252Fs12020-015-0650-6.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12020-015-0650-6&token2=exp=1434376491~acl=%2Fstatic%2Fpdf%2F869%2Fart%25253A10.1007%25252Fs12020-015-065 - 0 views

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    Opinion publication recommends total Testosterone as primary means of evaluating Testosterone.  This recommendation relies on the use of immunoassay techniques which can lack specificity compared to newer LC/MS and GC/MS techniques.  The authors did recommend using salivary Testosterone when borderline and SHBG variables play in, which happens to be most clients I see.  The best approach is to use both simultaneously to give a more clear physiologic picture to start.
Nathan Goodyear

Salivary testosterone: a reliable approach to the ... [Clin Endocrinol (Oxf). 2007] - PubMed result - 0 views

  • Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a noninvasive approach in the diagnosis of male androgen deficiency.
  • A cut-off value of Sal-T < or = 0.195 nm showed 100% sensibility and specificity to rule out hypogonadism.
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    Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism.
Nathan Goodyear

Seasonal variation of salivary testosterone in men, normally cycling women, and women using hormonal contraceptives - 0 views

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    study of 296 men with mean age at 22.7, have peak salivary Testosterone production in December and January. 
Nathan Goodyear

Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0 - 0 views

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    Only abstract available here, but sugar in the form of sucrose found to lower cortisol.  Increased activity in the hippocampus was evident in the sucrose arm of this study.  Both of these activities will lead to stress induced food addictions--particularly of sugar.  Sugar is highly addictive and should be especially avoided in children.  Of note, this study followed the cortisol levels through saliva.
Nathan Goodyear

Measurement of fasting salivary insulin and its relationship with serum insulin in children - 0 views

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    Salivary insulin correlates well with serum insulin.
Nathan Goodyear

Changes in Thymidine Kinase and α-Amylase Activity during Isoproterenol-stimulated DNA Synthesis in Mouse Salivary Gland - 0 views

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    salivary TK-1 increased in response to stimulated increased DNA synthesis in mouse model.
Nathan Goodyear

Exercise-Induced Responses in Salivary Testosterone, Cortisol, and ... - PubMed - NCBI - 0 views

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    Meta analysis of salivary Testosterone and cortisol finds mixed results.  The results are by no means uniform, but resistance training appears to trend to an increased salivary Testosterone and salivary Testosterone to salivary cortisol ratio.  Cardio trends the opposite.  This fits with prior literature on the types of exercise and hormone results.
Nathan Goodyear

Oral contraceptive use and saliva diurnal pattern of metabolic ster... - PubMed - NCBI - 0 views

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    Oral contraceptives shown to reduce Testosterone and DHEA in women, but no effect on cortisol was seen.
Nathan Goodyear

Acute phase protein and cytokine levels in... [Brain Behav Immun. 2013] - PubMed - NCBI - 0 views

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    Salivary CRP correlates with serum CRP in adolescents with inflammation.
Nathan Goodyear

Validation of a high-sensitivity assay for... [Brain Behav Immun. 2011] - PubMed - NCBI - 0 views

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    Exciting: salivary CRP found to correlate with serum CRP.
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