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Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

www.ncbi.nlm.nih.gov/...PMC3891651

Testosterone replacement transdermal low T male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
  • ...13 more annotations...
  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
Nathan Goodyear

Redefining Metabolic Syndrome in Men (July 2012) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...metsyndrome0712.html

testosterone male men hormone hormones saliva salivary low T low metabolic syndrome MetS

shared by Nathan Goodyear on 28 Aug 12 - No Cached
  • Approximately 95% to 98% of testosterone is bound to a carrier protein at any given time, leaving just the remaining 2% to 5% as completely unbound and available for tissues to use
  • most serum laboratories offer a free testosterone level, which is a calculated value based on SHBG levels or determined with equilibrium dialysis
  • the hormone enters the salivary gland by passive diffusion
  • ...11 more annotations...
  • Testosterone has a known age-related decline, and total levels typically drop by approximately 1.6% per year beginning for most men in their 30s
  • As estrogen levels rise, they prompt the body to produce more SHBG, which in turn has a higher binding affinity for testosterone, and drives the unbound fraction of the testosterone pool down even further
  • When the increase in SHBG is taken into account, the age-related decline in the level of hormone that can be used by the body is closer to 2% to 3% per year.
  • Stinging nettle (Urtica dioica), an herb commonly used for allergies, can also be employed to bind to SHBG, which leaves more testosterone available to tissues
  • Leptin, an adipose-derived peptide hormone that regulates appetite and metabolism, has been shown to directly inhibit testosterone production in animal models
  • tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) further inhibit Leydig cell testosterone production
  • Natural aromatase inhibitors include the bioflavonoids chrysin and luteolin
  • Zinc deficiency causes an upregulation of the aromatase enzyme
  • Testosterone reduces lipoprotein lipase (LPL) activity
  • there are several herbs that can work to boost testosterone levels, including longjack (Eurycoma longifolia), horny goat weed (Epimedium grandiflorum), and tribulus (Tribulus terrestris).
  • the majority of the hormone is bound to carrier proteins including sex hormone binding globulin (SHBG) and albumin
  • Nathan Goodyear on 28 Aug 12
     
    nice and short review on testosterone and men's  health.
Nathan Goodyear

Diagnostic significance of salivary testosterone measurement revisited: using liquid ch... - 0 views

www.jmhjournal.org/...abstract

saliva salivary mass spectroscopy liquid chromatography hormone hormones testosterone low T low testosterone LC-MS ELISA salivary hormone salivary hormones

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone, as measured by LC-MS and ELISA, showed strong correlation with serum free "calculated" testosterone.
Nathan Goodyear

Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease - 0 views

ndt.oxfordjournals.org/...ndt.gfq439.full

salivary saliva hormone hormones men male salivary hormone testing salivary hormone salivary hormones low T low testosterone

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone via immunoassay shown to have sensitivity and specificity to be 100%.  Very reliable method to test for testosterone levels.
Nathan Goodyear

Simultaneous d... [J Chromatogr B Analyt Technol Biomed Life Sci. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19010090

saliva salivary hormone hormones testing testosterone DHEA LC-MS_MS salivary hormone salivary hormones low T low testosterone liquid chromatography mass spectroscopy

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone and DHEA evaluation by LC-MS/MS validated and shown to be applicable in the diagnosis and therapy in those men with low testosterone and DHEA.
Nathan Goodyear

https://dl-web.dropbox.com/get/Public/Research/Salivary%20testosterone.pdf?w=AAA0jQi7Hq... - 0 views

dl-web.dropbox.com/...Salivary%20testosterone.pdf

saliva salivary hormone hormones testosterone low T low testosterone

shared by Nathan Goodyear on 07 Mar 13 - No Cached
  • Nathan Goodyear on 07 Mar 13
     
    salivary testosterone shown to be reliable measure of testosterone in men with suspected low T.
Nathan Goodyear

Salivary testosterone diurnal variation and psychopathology in adolescent males and fem... - 0 views

www.researchgate.net/...nces_and_developmental_effects

saliva salivary testosterone hormones hormone

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.
Nathan Goodyear

Pattern recognition of estradiol, testosterone and dihydrotestosterone in children's sa... - 0 views

www.nature.com/...srep05579.html

hormone hormones Estradiol Testosterone DHT dihydrotestosterone saliva salivary testing

shared by Nathan Goodyear on 02 Sep 14 - No Cached
  • Nathan Goodyear on 02 Sep 14
     
    Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children.  These levels are very low in pre-pubertal children and makes detection by ELIZA difficult.  This proposed mechanism improves hormone detection.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24573919

saliva salivary hormone hormones male men Testosterone Estradiol E2 obesity aromatase

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

Establishing circadian rhythm profiles for salivary testosterone in women: evidence of ... - 0 views

www.endocrine-abstracts.org/...ea0011p734.htm

saliva salivary testosterone hormone hormones women

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    salivary testosterone found to decline in women beyond the age of 39 with many women > 50 with low salivary testosterone levels.
Nathan Goodyear

Effect of meal fat content on salivary testosterone and cortisol levels in healthy fema... - 0 views

www.endocrine-abstracts.org/...ea0010p75.htm

Testosterone nutrition diet fat low T low Testosterone hormones saliva salivary hormones

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    higher fat diet found to increase cortisol and Testosterone levels post meal in health women.  The effect was first seen early after lunch (30 minutes).
Nathan Goodyear

Low salivary testosterone levels in patients with ... [BMC Cancer. 2010] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...20937135

salivary testosterone hormone saliva testing hormones

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Nathan Goodyear on 22 Nov 10
     
    Low salivary testosterone levels in patients with breast cancer
Nathan Goodyear

BioMed Central | Full text | Low salivary testosterone levels in patients with breast c... - 0 views

www.biomedcentral.com/...547

saliva testing salivary DHEAS hormone tesosterone hormones evaluation BHRT

shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • Nathan Goodyear on 16 Nov 10
     
    saliva testing used in breast cancer study
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