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Nathan Goodyear

The Diagnostic Applications of Saliva- A Review - 0 views

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    Fantastic article on the review of the clinical use of saliva testing.  Of note, is the extensive documentation of the validation studies of hormone saliva testing.  Clearly, if a physician is against saliva testing, it is because of a lack of knowledge on the subject.
Nathan Goodyear

[Bone and Men's Health. Measurement of salivary te... [Clin Calcium. 2010] - PubMed result - 0 views

  • Testosterone is secreted into saliva. In saliva, testosterone is not bound to proteins. Thus concentration of testosterone in saliva is quite close to the serum free testosterone level. Currently serum free testosterone is measured by a convenient method in Japan, that reflects only 10% of the correct values. However, the correct measurement of serum free testosterone is quite costly. Collection of saliva is not invasive to subjects, and it can be done without paramedicals. Besides it is relatively cheaper. Acquisition of samples in multiple occasions is possible. These advantages of utilizing saliva will introduce the measurements of salivary testosterone in cohort studies or screening of low testosterone levels in the community.
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    Saliva Testing of Testosterone is standard
Nathan Goodyear

Steroid Analysis in Saliva: An overview - 0 views

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    No test is perfect. This study analyzes problems with saliva hormone testing.  The authors of this study found saliva testing optimal for cortisol and less so for sex hormones.  Other studies have contradicted this conclusion.
Nathan Goodyear

Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development - 0 views

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    Saliva is proving to be an exciting medium for functional testing.  Recently, studies have found saliva as a great medium to evaluate for cancer biomarkers.  This study find pancreatic cancer biomarkers in saliva.
Nathan Goodyear

Percutaneous progesterone delivery via cream or gel application in postmenopausal women... - 0 views

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    Topical hormones best evaluated via saliva and/or blood spot. Urine and particularly serum does not increase with dosing.  That does not mean the topical hormone therapy is ineffective, just that serum and urine are not optimal to follow topical therapy.  When looking at endogenous hormones without any therapies: serum, saliva, urine, and blood spot are equivalent.
Nathan Goodyear

Diagnostic Potential of Saliva: Current State and Future Applications - 0 views

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    saliva testing is the new "gold standard" for hormone evaluation.  No testing method is perfect and thus there are guidelines for salivary collections.  However, saliva is equal too or superior to blood for hormone evaluation.
Nathan Goodyear

A Critical evaluation of salivary testosterone as a... [Steroids. 2014] - PubMed - NCBI - 0 views

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    Since when did one medium of evaluation become the only standard.  Since serum T has been the historical standard, that is the only window of evaluation??  This study points to higher free Testosterone levels in saliva versus serum. Has anyone ever thought that we are merely looking through different windows of the same process.  Each window here, serum and saliva, are merely giving us different information on hormones.  That doesn't make one right or wrong, it just requires interpretation.  Science is about being objective! Saliva is the best means to evaluate intracellular hormone levels.  These levels should be different than serum.  Why should anyone think that the total levels would correlate with that delivered to a cell.  Think.
Nathan Goodyear

Saliva as a diagnostic tool in medical science : a review study. - Free Online Library - 0 views

  • Saliva is a wonderful marker of early disease detection that leads to more effective treatment, risk assessment for future oral and systemic disease, and a simple, non invasive alternative to blood and urine tests
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    saliva testing used in early disease detection
Nathan Goodyear

Salivary Sex Hormone Measurement in a National, Population-Based Study of Older Adults - 0 views

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    Another study supports saliva hormone testing.  This study involved 2,722 individuals and tested estradiol, progesterone, DHEA and testosterone in men and women.  All of these are sex hormones.  Someone needs to tell the insurance companies that the overwhelming evidence supports saliva hormone testing.  But, that would mean they are even interested in the science.
Nathan Goodyear

Current Status of Salivary Hormone Analysis -- Gröschl 54 (11): 1759 -- Clini... - 0 views

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    saliva testing of hormones said to be "reliable and, in some cases, even superior to other body fluids".  Of course, no test is perfect, but saliva test provides that best assessment available
Nathan Goodyear

Steroids in Saliva for Assessing Endocrine Function - 0 views

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    Another study validates saliva as a reliable method for hormone testing.  The author concludes: "steroid concentrations in saliva are independent of flow rate and reflect those in the free fraction in plasma".  This study also discuss potential collection problems and means to resolve them.
Nathan Goodyear

Saliva estriol measurements: an alternative to the... [J Clin Endocrinol Metab. 1983] -... - 0 views

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    statement, "assay of saliva E3 should replace serum E3 measurement..."  Saliva testing is very sound science!
Nathan Goodyear

Human saliva as a diagnostic specimen. [J Nutr. 2001] - PubMed result - 0 views

  • Saliva can be used as a diagnostic specimen not only to obtain information more inexpensively and efficiently than serum, but also to provide information not readily available from serum testing.
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    saliva testing validated for diagnostic testing
Nathan Goodyear

Salivary testosterone measurements in growing pi... [Res Vet Sci. 2014] - PubMed - NCBI - 0 views

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    validation of saliva testing in animals.  The point is saliva testing for Testosterone is valid.
Nathan Goodyear

Steroid hormone analysis in human saliva. [Ann N Y Acad Sci. 1993] - PubMed result - 0 views

  • saliva collection has provided the medical and research community with an excellent medium for the monitoring of plasma steroid levels
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    saliva testing is excellent medium for testing
Nathan Goodyear

Simultaneous measurement of cortisol in serum and saliva after different forms of corti... - 0 views

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    salivary cortisol shown to accurately reflect the systemic cortisol burden.  This study concluded that saliva cortisol was an accurate assessment tool for the free, biological cortisol in the body.  Saliva an appropriate assessment tool, in the place of serum.
Nathan Goodyear

Chewing gum has large effects on salivary testosterone, estradiol, and secretory immuno... - 0 views

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    Don't chew gum to increase saliva for saliva testing.
Nathan Goodyear

ScienceDirect - Pathologie Biologie : Saliva assays in clinical and research biology - 0 views

  • the saliva concentration reflects the free blood concentration.
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    saliva testing of stress and sex hormones have been utilized since the early 1980's and described as "well validated" in the literature.
Nathan Goodyear

Sex hormones and cognitive functioning in men. [Neuropsychobiology. 1987] - PubMed result - 0 views

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    saliva testing and male hormones
Nathan Goodyear

Cortisol in saliva--reference ranges and relation ... [Eur J Clin Chem Clin Biochem. 19... - 0 views

  • In conclusion, the satisfactory precision of the analysis and the simple non-invasive sampling procedure suggest that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.
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    saliva testing validated for cortisol
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