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Nathan Goodyear

Exercise-Induced Responses in Salivary Testosterone, Cortisol, and ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25655373

saliva salivary hormone hormones Testosterone cortisol exercise resistance training aerobic exercise

shared by Nathan Goodyear on 16 Feb 15 - No Cached
  • Nathan Goodyear on 16 Feb 15
     
    Meta analysis of salivary Testosterone and cortisol finds mixed results.  The results are by no means uniform, but resistance training appears to trend to an increased salivary Testosterone and salivary Testosterone to salivary cortisol ratio.  Cardio trends the opposite.  This fits with prior literature on the types of exercise and hormone results.
Nathan Goodyear

Comparison of salivary versus serum testos... [Menopause. 2009 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19325500

saliva salivary hormones hormone testosterone serum testing postmenopausal women menopause

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

www.ncbi.nlm.nih.gov/...PMC2825741

CAG androgen receptors AR androgen receptor Testosterone hormone hormones male men

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
  • Nathan Goodyear on 22 Jun 15
     
    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Measuring salivary androgens as a useful tool... [Endokrynol Pol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22744623

PCOS saliva salivary testing hormone hormones testosterone androstenedione

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    Study shows good predictive value, with very high correlation with free serum levels, of salivary androstenedione and salivary Testosterone levels in women with PCOS. This study suggests using salivary androstenedione:salivary testosterone be used in the diagnosis of PCOS.
Nathan Goodyear

Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease - 0 views

ndt.oxfordjournals.org/...ndt.gfq439.full

salivary saliva hormone hormones men male salivary hormone testing salivary hormone salivary hormones low T low testosterone

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone via immunoassay shown to have sensitivity and specificity to be 100%.  Very reliable method to test for testosterone levels.
Nathan Goodyear

Diagnostic significance of salivary testosterone measurement revisited: using liquid ch... - 0 views

www.jmhjournal.org/...abstract

saliva salivary mass spectroscopy liquid chromatography hormone hormones testosterone low T low testosterone LC-MS ELISA salivary hormone salivary hormones

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone, as measured by LC-MS and ELISA, showed strong correlation with serum free "calculated" testosterone.
Nathan Goodyear

Further evidence for the usefulness of the salivary... [Horm Res. 1986] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3943772

saliva salivary hormone hormones testosterone men women testing

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    salivary testosterone found to be reliable in men and women during testosterone therapy.  The salivary testosterone levels correlated with serum.
Nathan Goodyear

Redefining Metabolic Syndrome in Men (July 2012) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...metsyndrome0712.html

testosterone male men hormone hormones saliva salivary low T low metabolic syndrome MetS

shared by Nathan Goodyear on 28 Aug 12 - No Cached
  • Approximately 95% to 98% of testosterone is bound to a carrier protein at any given time, leaving just the remaining 2% to 5% as completely unbound and available for tissues to use
  • most serum laboratories offer a free testosterone level, which is a calculated value based on SHBG levels or determined with equilibrium dialysis
  • the hormone enters the salivary gland by passive diffusion
  • ...11 more annotations...
  • Testosterone has a known age-related decline, and total levels typically drop by approximately 1.6% per year beginning for most men in their 30s
  • As estrogen levels rise, they prompt the body to produce more SHBG, which in turn has a higher binding affinity for testosterone, and drives the unbound fraction of the testosterone pool down even further
  • When the increase in SHBG is taken into account, the age-related decline in the level of hormone that can be used by the body is closer to 2% to 3% per year.
  • Stinging nettle (Urtica dioica), an herb commonly used for allergies, can also be employed to bind to SHBG, which leaves more testosterone available to tissues
  • Testosterone reduces lipoprotein lipase (LPL) activity
  • tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) further inhibit Leydig cell testosterone production
  • Natural aromatase inhibitors include the bioflavonoids chrysin and luteolin
  • Zinc deficiency causes an upregulation of the aromatase enzyme
  • Leptin, an adipose-derived peptide hormone that regulates appetite and metabolism, has been shown to directly inhibit testosterone production in animal models
  • there are several herbs that can work to boost testosterone levels, including longjack (Eurycoma longifolia), horny goat weed (Epimedium grandiflorum), and tribulus (Tribulus terrestris).
  • the majority of the hormone is bound to carrier proteins including sex hormone binding globulin (SHBG) and albumin
  • Nathan Goodyear on 28 Aug 12
     
    nice and short review on testosterone and men's  health.
Nathan Goodyear

[Bone and Men's Health. Measurement of salivary te... [Clin Calcium. 2010] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...20118513

saliva salivary testosterone biodentical testng

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Testosterone is secreted into saliva. In saliva, testosterone is not bound to proteins. Thus concentration of testosterone in saliva is quite close to the serum free testosterone level. Currently serum free testosterone is measured by a convenient method in Japan, that reflects only 10% of the correct values. However, the correct measurement of serum free testosterone is quite costly. Collection of saliva is not invasive to subjects, and it can be done without paramedicals. Besides it is relatively cheaper. Acquisition of samples in multiple occasions is possible. These advantages of utilizing saliva will introduce the measurements of salivary testosterone in cohort studies or screening of low testosterone levels in the community.
  • Nathan Goodyear on 22 Nov 10
     
    Saliva Testing of Testosterone is standard
Nathan Goodyear

Establishing circadian rhythm profiles for salivary testosterone in women: evidence of ... - 0 views

www.endocrine-abstracts.org/...ea0011p734.htm

saliva salivary testosterone hormone hormones women

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    salivary testosterone found to decline in women beyond the age of 39 with many women > 50 with low salivary testosterone levels.
Nathan Goodyear

Endocrinology of the Aging Male - 0 views

www.ncbi.nlm.nih.gov/...PMC3073592

aging male hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • All steps beyond the formation of pregnenolone take place in the smooth endoplasmic reticulum
  • Cytochrome P450 enzyme, CYP11A is located on the inner mitochondrial membrane and catalyses the rate limiting step of pregnenolone synthesis
  • Estrogen and related steroids, thyroid hormone and insulin increase SHBG levels.
  • ...21 more annotations...
  • SHBG decreases in response to androgens, and in the presence of hypothyroidism, and insulin resistance.
  • Plasma SHBG levels tend to increase with increasing age
  • The apparent metabolic clearance rate of testosterone is decreased in elderly as compared to younger men
  • Testosterone circulates predominantly bound to the plasma proteins SHBG and albumin, with high and low affinity respectively
  • Testosterone is secreted in a pulsatile fashion
  • Current clinical guidelines suggest at least two measurements
  • In adult men, there is a well-documented diurnal variation (particularly in younger subjects) in testosterone levels, which are highest in the early morning and progressively decline throughout the day to a nadir in the evening
  • In older men, the diurnal variation is blunted
  • it is standard practice for samples to be obtained between 0800 and 1100 h.
  • Testosterone and DHEA decline, whereas LH, FSH, and SHBG rise
  • DHT remains constant despite the decline of its precursor testosterone
  • Longitudinal studies show an average annual decline of 1–2% total testosterone levels, with decline in free testosterone more rapid because of increases in SHBG with aging
  • Massachusetts Male Aging Study (MMAS) data show DHEA, DHEAS, and Ae declining at 2–3% per year
  • DHT showed no cross-sectional age trend
  • Androstanediol glucuronide (AAG) declined cross-sectionally with age in the MMAS sample, at 0.6% per year
  • The EMAS data show that, consistent with the longitudinal findings of MMAS (Figure 1), the core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total testosterone and progressively blunted free testosterone associated with higher LH
    • Nathan Goodyear
      Nathan Goodyear on 01 May 13
       
      This author proves the point in the review of these two studies, that TT may remain constant in aging men, however, FT drops.
  • obesity impairs hypothalamic/pituitary function
  • Androgen deprivation in men with prostate cancer has been associated with increased insulin resistance, worse glycemic control, and a significant increase in risk of incident diabetes
  • Low serum testosterone is associated with the development of metabolic syndrome 116, 117 and type 2 diabetes. 118 SHBG has been inversely correlated with type 2 diabetes
  • Improvement in insulin sensitivity with testosterone treatment has been reported in healthy 121 and diabetic 122 adult men
  • In studies conducted in men with central adiposity, testosterone has been shown to inhibit lipoprotein lipase activity in abdominal adipose tissue leading to decreased triglyceride uptake in central fat depots. 123
  • Nathan Goodyear on 30 Apr 13
     
    great review of hormone changes associated with aging in men.
Nathan Goodyear

[Serum and salivary testosterone levels in erectil... [Orv Hetil. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9745307

testosterone saliva salivary hormone hormones ED men male

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    Small study looking at testosterone in men with ED.  They found "serum total testosterone level is not a sensitivity indicator for detection of hypogonadism".  Salivary free testosterone levels is the best way to evaluate androgen levels.
Nathan Goodyear

Simultaneous d... [J Chromatogr B Analyt Technol Biomed Life Sci. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19010090

saliva salivary hormone hormones testing testosterone DHEA LC-MS_MS salivary hormone salivary hormones low T low testosterone liquid chromatography mass spectroscopy

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone and DHEA evaluation by LC-MS/MS validated and shown to be applicable in the diagnosis and therapy in those men with low testosterone and DHEA.
Nathan Goodyear

https://dl-web.dropbox.com/get/Public/Research/Salivary%20testosterone.pdf?w=AAA0jQi7Hq... - 0 views

dl-web.dropbox.com/...Salivary%20testosterone.pdf

saliva salivary hormone hormones testosterone low T low testosterone

shared by Nathan Goodyear on 07 Mar 13 - No Cached
  • Nathan Goodyear on 07 Mar 13
     
    salivary testosterone shown to be reliable measure of testosterone in men with suspected low T.
Nathan Goodyear

SALIVARY TESTOSTERONE: RELATIONSHIP TO UNBOUND PLASMA TESTOSTERONE IN NORMAL AND HYPERA... - 0 views

onlinelibrary.wiley.com/...abstract

SALIVARY TESTOSTERONE

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Nathan Goodyear on 12 Jul 11
     
    salivary testosterone is a reliable way to evaluate free testosterone
Nathan Goodyear

Validation of salivary testosterone as a screening... [Aging Male. 2006] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...17050116

hormones hormone saliva testing salivary bioidentical testosterone

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • hese studies support the use of salivary testosterone as an acceptable assay for screening for hypogonadism.
  • Nathan Goodyear on 22 Nov 10
     
    Validation of salivary testosterone as a screening test for male hypogonadism.
Nathan Goodyear

http://download.springer.com/static/pdf/869/art%253A10.1007%252Fs12020-015-0650-6.pdf?o... - 0 views

download.springer.com/...1007%252Fs12020-015-0650-6.pdf

saliva salivary Testosterone Testosterone hormone hormones

shared by Nathan Goodyear on 15 Jun 15 - No Cached
  • Nathan Goodyear on 15 Jun 15
     
    Opinion publication recommends total Testosterone as primary means of evaluating Testosterone.  This recommendation relies on the use of immunoassay techniques which can lack specificity compared to newer LC/MS and GC/MS techniques.  The authors did recommend using salivary Testosterone when borderline and SHBG variables play in, which happens to be most clients I see.  The best approach is to use both simultaneously to give a more clear physiologic picture to start.
Nathan Goodyear

Salivary testosterone diurnal variation and psychopathology in adolescent males and fem... - 0 views

www.researchgate.net/...nces_and_developmental_effects

saliva salivary testosterone hormones hormone

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.
Nathan Goodyear

Diagnostic significance of free salivary testosterone measurement using a direct lumine... - 0 views

informahealthcare.com/...13685530600713060

saliva salivary men testosterone testing aging

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    salivary testosterone found to correlate will with blood free testosterone in men.
Nathan Goodyear

Age related variation of salivary testosterone va... [Aging Male. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17178556

saliva salivary testosterone men male hormone hormones weight obesity BMI

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    This study looked at declining testosterone in Japanese men. The significant decrease was found in those men between 20 and through 40s.  Beyond which statistical decline was not found.  Also of note, lower salivary testosterone was associated with higher BMI
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