ScienceDirect - Toxicology and Applied Pharmacology : The potential biological mechanisms of arsenic-induced diabetes mellitus - 0 views
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Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) is upregulated
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these two cytokines have been well known for their effect on the induction of insulin resistance
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Oxidative stress has been suggested as a major pathogenic link to both insulin resistance and β cell dysfunction through mechanisms involving activation of nuclear factor-κB (NF-κB), which is also activated by low levels of arsenic