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Nathan Goodyear

Testosterone treatment and mortality in men with low testosterone levels, "Beyond the A... - 0 views

www.urotoday.com/...-and-alvin-m-matsumoto-md.html

testosterone treatment mortality low T low testosterone men male

shared by Nathan Goodyear on 06 Feb 13 - No Cached
  • Nathan Goodyear on 06 Feb 13
     
    Long term study finds testosterone therapy associated with reduced mortality in men.
Mysmart Spine

Dr. Eduardo Anguizola - Pain Management Specialist in California - 0 views

www.mysmartspine.com/eduardo-anguizola.php

Pain management services Dr. Eduardo Anguizola Pain Management Specialist conservative care international treatment American Medical Association California Arcadia Smart Spine Institute Spine

shared by Mysmart Spine on 18 Jun 13 - No Cached
  • Mysmart Spine on 18 Jun 13
     
    Dr Eduardo Anguizola, MD. a Member of American Medical Association and best Pain Management Specialist in California; offers full pain management services including conservative care to international treatment.
Nathan Goodyear

Hormone Balance in Males - 0 views

www.johnleemd.com/...male_hormone.html

hormone therapy hormonal BHRT testosterone estrogen estradiol andropause saliva testing salivary male hormones balance

shared by Nathan Goodyear on 10 Oct 11 - Cached
  • Nathan Goodyear on 10 Oct 11
     
    Fantastic article written by John Lee, MD.  This article is a great review on saliva testing and hormone therapy as it relates to both men and women; even though this article is in reference to men.  Worth your time to read
Nathan Goodyear

http://partnecglobal.eurasiansupply.com/ds/rd/rdgf/_pdf7.pdf - 0 views

partnecglobal.eurasiansupply.com/..._pdf7.pdf

maitake mushrooms cancer beta-glucan Grifola frondosa NK APC antigen presenting cells ICAM-1

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Study finds that maitake mushroom extract, MD-Fraction (a beta-glucan), has significant anti-tumor activity and anti-metastasis activity through NK activity, Antigen presenting cells, and through suppression of ICAM-1.
Nathan Goodyear

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine | PNAS - 0 views

www.pnas.org/10238

AML leukemia acute myeloid leukemia MDS vitamin C cancer

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Vitamin C alone at concentrations up to 57 μM had little effect on cell growth but was toxic at 228 μM (SI Appendix, Fig. S1B), in line with recent studies of high vitamin C concentrations (125–2,000 μM)
  • In our combination approach, vitamin C increased the effects of low doses of 5-aza-CdR, with 57 μM vitamin C almost doubling the growth inhibition
  • Using the Chou–Talalay method (28), we found that the two compounds indeed acted synergistically, rather than additively, to inhibit cancer cell growth over the physiological ranges of vitamin C in healthy individuals (26–84 μM)
  • ...12 more annotations...
  • These results show that targeting the cancer DNA methylome by combining low-dose 5-aza-CdR and vitamin C stimulates the expression of ERVs, the induction of a cell-autonomous immune activation response, and increased apoptosis of cancer cells
  • The addition of vitamin C to treatment protocols therefore may be a straightforward way to increase the clinical efficacy of such drugs in MDS and leukemia patients
  • Vitamin C deficiency has been seen previously in patients with multiple types of cancer, including hematological malignancies (35⇓–37). We predict that these patients might receive the most benefits from the combination treatment.
  • induction of an innate immune response
  • We therefore measured plasma concentrations of vitamin C in a small number of patients with miscellaneous hematologic malignancies. Strikingly, 58% of patients with hematological neoplasia who were not taking vitamin C supplements had severe vitamin C deficiency (serum concentration <11.4 μM, at which clinical features of scurvy may be manifested) (34), and 33% had vitamin C levels below the normal range
  • it is possible that vitamin C was oxidized to DHA before it was transported into the cells
  • Oral administration of vitamin C should be sufficient for the therapeutic strategy, because the concentrations reported in this study would not require i.v. administration.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 18
       
      This statement lacks a basic understanding of vitamin C pharmacokinetics.
  • Vitamin C is an essential nutrient for humans and has been reported to increase IFN levels in human cells upon virus infection
  • daily treatment with vitamin C alone at physiological concentrations enhanced the expression of viral-defense genes relative to untreated cells
  • When combined with low-dose 5-aza-CdR, physiological concentrations of vitamin C synergistically inhibited cancer-cell growth and induced apoptosis. Such synergy was associated with increased ERV expression and dsRNA in treated cells. The mechanism of action differs from that of vitamin C at higher doses, which involves its pro-oxidant activity, including GSH inhibition, to generate reactive oxygen species
  • This activity has been shown to induce DNA damage and to enhance the sensitivities of myeloid malignancies, multiple myeloma, and cutaneous T-cell lymphoma to arsenic trioxide (41⇓⇓–44). It also can increase chemosensitivity of ovarian cancer cells (27) and selectively kill KRAS or BRAF mutant colorectal cancer cells by inhibiting GAPDH
  • reactive oxygen species
  • Nathan Goodyear on 12 May 18
     
    91% of patients with hematologic malignancies have vitamin C levels that are either low or severly deficient. This study found that vitamin C plus low dose DNA methyltransferase inhibitors have synergistic inhibition of cancer cell proliferation and increased apoptosis.  Unfortunately, the authors claimed that oral vitamin C would be sufficient which indicates an incredible lack of understanding of vitamin C pharmacokinetics.
Nathan Goodyear

A TRIFfic Perspective on Acute Lung Injury: Cell - 0 views

www.cell.com/...S0092-8674(08)00454-6

toll-like receptors cytokine storm SARS pattern recognition receptors MERS IL-6 PRR TLR4

shared by Nathan Goodyear on 19 May 20 - No Cached
  • Nathan Goodyear on 19 May 20
     
    Recognition of TLR4 PRR involvement in cytokine storm from SARS all the way back to 2008. Md88 and TRIF involved.
toxlab

Tox lab billing and collections - 2 views

nath-mds.com/...specialty-labs

medical billing and management services online

shared by toxlab on 09 May 16 - No Cached
  • toxlab on 09 May 16
     
    To ease off the process of tox lab billing and collections, Nath has rolled out software which is a perfect blend of multiple processes, contemporary technology and the manpower involved. Check out today and incorporate it into your system effortlessly!
Nathan Goodyear

ScienceDirect - Journal of Psychosomatic Research : Stress, inflammation and cardiovasc... - 1 views

www.sciencedirect.com/science

inflammation stress heart disease cardiovascular

shared by Nathan Goodyear on 24 Jan 11 - No Cached
  • Nathan Goodyear on 24 Jan 11
     
    Wow.  How your stress contributes to your heart disease risk
Nathan Goodyear

ScienceDirect - Brain, Behavior, and Immunity : Stress and the inflammatory response: A... - 2 views

www.sciencedirect.com/science

stress brain inflammation

shared by Nathan Goodyear on 24 Jan 11 - No Cached
  • Nathan Goodyear on 24 Jan 11
     
    stress and the inflammatory response
Nathan Goodyear

ScienceDirect - Trends in Immunology : Inflammation: the link between insulin resistanc... - 0 views

www.sciencedirect.com/science

inflammation obesity insulin resistance diabetes

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • Inflammation: the link between insulin resistance, obesity and diabetes
  • Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations of TNF-α and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction. This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
  • Nathan Goodyear on 09 Mar 11
     
    Inflammation: the link between insulin resistance, obesity and diabetes
Nathan Goodyear

ScienceDirect - Molecular Immunology : Mechanisms of heavy metal-induced autoimmunity - 0 views

www.sciencedirect.com/science

autoimmunity immunology heavy metals

shared by Nathan Goodyear on 16 Mar 11 - No Cached
  • Mechanisms of heavy metal-induced autoimmunity
  • Nathan Goodyear on 16 Mar 11
     
    Heavy metals and autoimmune disease
Nathan Goodyear

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from... - 0 views

onlinelibrary.wiley.com/...full

LDL Parkinson's disease

shared by Nathan Goodyear on 07 Oct 11 - No Cached
  • Nathan Goodyear on 07 Oct 11
     
    study shows that low LDL increased the risk of Parkinson's disease.  Be careful to not lower your LDL too much.  LDL is not "BAD" cholesterol.
Nathan Goodyear

ScienceDirect - Food and Chemical Toxicology : Neuroprotective effect of ginger on anti... - 0 views

www.sciencedirect.com/science

Ginger diabetes oxidative stress

shared by Nathan Goodyear on 27 Apr 11 - No Cached
  • A marked decrease in anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and increase in malondialdehyde (MDA) was observed in the diabetic rats
  • inger may be used as therapeutic agent in preventing complications in diabetic patients.
  • These results suggest that ginger exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating the MDA levels to the normal levels in the diabetic rats
  • Nathan Goodyear on 27 Apr 11
     
    Ginger reduces oxidative stress in diabetic rat model
Nathan Goodyear

Intralesional and subcutaneous application of Viscum album L... : Medicine - 0 views

journals.lww.com/...articleviewer.aspx

intra-tumoral injection cancer Mistletoe cervical cancer

shared by Nathan Goodyear on 21 Apr 20 - No Cached
  • Nathan Goodyear on 21 Apr 20
     
    To be read
Nathan Goodyear

Prolonged stabilization of platinum-refractory ovarian cance... : Medicine - 0 views

journals.lww.com/...articleviewer.aspx

ascites Intra-peritoneal mistletoe ovarian cancer cancer

shared by Nathan Goodyear on 07 Apr 21 - No Cached
  • Nathan Goodyear on 07 Apr 21
     
    Mistletoe injected intraperitoneal 3 x weekly to reduce ascites.
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