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Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthes... - 0 views

www.ajcn.org/...402.abstract omega-3
shared by Nathan Goodyear on 25 Mar 11 - No Cached
  • Omega-3 fatty acids stimulate muscle protein synthesis in older adults
  • Nathan Goodyear on 25 Mar 11
     
    Omega-3 shown to increase muscle growth
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Leptin stimulates fatty-acid oxidation by activati... [Nature. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11797013 leptin fat obesity
shared by Nathan Goodyear on 10 Mar 11 - No Cached
  • Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of fatty acids and the uptake of glucose, and prevents the accumulation of lipids in nonadipose tissues, which can lead to functional impairments known as "lipotoxicity"
  • Nathan Goodyear on 10 Mar 11
     
    Leptin and fat accumulation called "lipotoxicity"
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Mechanisms of fatty acid-induced inhibition of glucose uptake. - 0 views

www.ncbi.nlm.nih.gov/...PMC294452 saturaged fat fatty acids insulin glucose obesity overweight
shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    saturated fat with glucose intake promotes triglyceride synthesis by insulin instead of glucose uptake into tissue to make energy
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Non-Alcoholic Fatty Liver Disease and Fructose: Bad for Us, Better for Mice - 0 views

www.ncbi.nlm.nih.gov/...PMC3117982 HCFS NAFLD high fructose corn syrup non-alcoholic fatty liver disease obesity overweight epidemic
shared by Nathan Goodyear on 19 Aug 11 - No Cached
  • Nathan Goodyear on 19 Aug 11
     
    great read on how HCFS has significantly contributed to the obesity epidemic and the new epidemic of NAFLD
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Omega-3 fatty acids (fish oil) as an anti-inflam... [Surg Neurol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16531187 Omega-3 fish oil fatty acids pain inflammation
shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    omega-3 equivalent to NSAIDS in pain management and inflammation
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n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases - 0 views

www.ajcn.org/...S1505.full Omega-3 fatty acids fish oil inflammation inflammtory disease diseases
shared by Nathan Goodyear on 13 Sep 11 - No Cached
  • Nathan Goodyear on 13 Sep 11
     
    Take omega-3 to reduce inflammation!
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Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases - 0 views

www.jacn.org/...495.full Omega-3 fatty acids inflammation autoimmune diseases
shared by Nathan Goodyear on 13 Sep 11 - No Cached
  • Nathan Goodyear on 13 Sep 11
     
    Omega-3 reduces inflammation in patients with autoimmune disease
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Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for dev... - 0 views

www.ajcn.org/...281.abstract long-chain fatty acid brain development function behavioral DHA Omega-3
shared by Nathan Goodyear on 06 Sep 11 - No Cached
  • Nathan Goodyear on 06 Sep 11
     
    changes in brain concentrations of DHA (omega-3) are positively associated with changes in cognitive or behavioral performance
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(n-3) Fatty Acids: Clinical Trials in People with Type 2 Diabetes - 0 views

advances.nutrition.org/...3.short omega-3 trigylcerides hypertriglyceridemia
shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • had varying effects on serum cholesterol, LDL cholesterol, and HDL cholesterol
  • (n-3) Fatty acids generally decreased serum triglycerides
  • Nathan Goodyear on 28 Apr 11
     
    Omega 3 review lowers triglycerides
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Omega-3 fatty acids in juvenile idiopathic ar... [Clin Rheumatol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21922187 Omega-3 n-3 Fish oil inflammation idiopathic arthritis NSAIDS IL-1 TNF-alpha fatty acids
shared by Nathan Goodyear on 21 Oct 11 - No Cached
  • Nathan Goodyear on 21 Oct 11
     
    Omega-3 intake reduced inflammation and pain in Juvenile idiopathic arthritis.  Associated inflammatory markers were decreased in study.  Anti-inflammatory drug usage was decreased as well.
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Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspectiv... - 0 views

press.endocrine.org/...jc.2013-3092 toll like receptors toll-like receptors TLRs TLR-4 TLR4 inflammation metabolic syndrome MetS insulin resistance IR Diabetes obesity
shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.
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Relationship between non-alcoholic fatty liver ... [World J Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25189458 NAFLD BPH LUTS men male fatty liver liver metabolic syndrome
shared by Nathan Goodyear on 09 Sep 14 - No Cached
  • Nathan Goodyear on 09 Sep 14
     
    Men with NAFLD have higher incidence of lower urinary tract symptoms including BPH.
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Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cycloo... - 0 views

www.jbc.org/...16683.long TLR-4 TLR4 TLR DHA EPA toll like receptors Toll-like receptors omega 3 omega-3 inflammation NF-kappaB lkappaB-alpha lkkb
shared by Nathan Goodyear on 11 Sep 14 - No Cached
  • Nathan Goodyear on 11 Sep 14
     
    OMega-3 inhibits inflammation via decreased phosphorylation of lkappaBalpha and resultant decreased disassociation of NF-kappaB and decreased cytokine production.  This occurs through TLR-4.
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Neurological benefits of omega-3 fatty acids. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18543124 EPA DHA omega 3 omega-3 essential fatty acids brain
shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    EPA/DHA are highly concentrated in neuronal synapse.
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Making the Right Fish Choices: Fatty Acid Contents of 33 Different Fish Species. Plus: ... - 0 views

suppversity.blogspot.com/...t-fish-choices-fatty-acid.html omega 3 omega-3 omega-6 fish nutrition diet
shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    I don't normally post blog posts, however, this post has merits for the purpose of figure 1 and figure 2.   Figure 1 highlights the different omega 3:omega 6 of different fish and figure 2 highlights the different omega3;6 in wild versus farm raised fish.
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EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence... - 0 views

www.sciencedirect.com/...S0085253815505322 inflammation omega 3 omega-3 EPA DHA LPS lipopolysaccharides NF-kappaB PPAR-gamma
shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Omega 3 essential fatty acids, specifically EPA and DHA, decrease LPS activation of NF-kappaB via PPAR-gamma activation.
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Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde... - 0 views

www.hindawi.com/...360438 MDA malondialdehyde peroxidation oxidative stress free radicals
shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
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LeanBiome™ (Official) | Get Save UpTo $540 Today Only! - 0 views

usleanbiome.com leanbiome us lean biome usa uk buy get does work discount 2022 australia legit weight loss bioma customer reviews review canada website ireland product
shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
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The monounsaturated fatty acid intake modulates the effect of ADIPOQ polymorphisms on o... - 0 views

www.ncbi.nlm.nih.gov/...PMC2753535 genetics obesity epigenetics SNPs adiponectin diet
shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • Nathan Goodyear on 21 Jan 13
     
    Epigenetics: the interplay between genetics and the environment.  They influence each other.  This study shows how genetic SNPs influence the impact of lipid metabolism in overweight white people.  The genetic SNPs influenced how the individuals metabolized dietary fat intake.
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Adipocyte Signaling and Lipid Homeostasis - 0 views

circres.ahajournals.org/...1042.long insulin resistance IR insulin lipid metabolism lipids adipose tissue adipose tissue fatty acids
shared by Nathan Goodyear on 04 Mar 13 - No Cached
  • Nathan Goodyear on 04 Mar 13
     
    great review of how insulin resistance effects lipid metabolism homeostasis.
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