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Nathan Goodyear

Making the Right Fish Choices: Fatty Acid Contents of 33 Different Fish Species. Plus: ... - 0 views

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    I don't normally post blog posts, however, this post has merits for the purpose of figure 1 and figure 2.   Figure 1 highlights the different omega 3:omega 6 of different fish and figure 2 highlights the different omega3;6 in wild versus farm raised fish.
Nathan Goodyear

Dietary selenium's protective effects against methylmercury toxicity. - PubMed - NCBI - 0 views

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    Selenium versus methyl mercury content of fish renders the argument of mercury content of fish as a concern, but in a few fish.
Nathan Goodyear

Fish consumption among healthy adults is associated with decreased levels of inflammato... - 0 views

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    Only abstract available here but higher fish intake associated with a decrease in CRP, IL-6, TNF-alpha, amyloid A and WBC; restated, higher fish intake associated with a reduction of inflammation
Nathan Goodyear

Methylmercury > Mercury Concentrations in Fish: FDA Monitoring Program - 0 views

  • Mercury Concentrations in Fish
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    Mercury Concentrations in Fish
Nathan Goodyear

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products - 0 views

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    Good read on the omega 3 versus omega 6 content of different fish.
Nathan Goodyear

Fish Oil Triglycerides vs. Ethyl Esters: A comparative review of absorption, stability ... - 0 views

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    Nice review of the difference, and the science, behind triacylglycerols and ethyl esters.
Nathan Goodyear

Fish oil compares favorably to montelukast Singular in reducing the - 0 views

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    n-3 equivalent to singulair in the treatment of asthma.
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
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  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[150] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[217] relative risk for ischemic stroke,[2] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[128,194,236] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[63,97] Alzheimer's disease,[109] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[97] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[37]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
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    great review of natural therapies in the treatment of concussions
Smile Reef

Fish Tank At SmileReef - Smile Reef Pediatric Dentistry - 0 views

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    Smile Reef is the premier Pediatric Dentist office in Las Vegas and has been specially designed to be attractive, calming and inviting for your children. They'll love the "tropical-surf-beach-scuba-adventure-ish" themes-including exploring the colorful salt water fish tank and interactive play place. Contact Smile Reef Pediatric Dentistry Phone: (702) 570-7333 Address: 9500 West Flamingo Road #200 Las Vegas,NV, United States, 89147 Site: smilereef.com/ Facebook: www.facebook.com/smilereef
Nathan Goodyear

Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: me... - 0 views

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    Omega 3 associated with decrease Breast cancer risk in women.
Nathan Goodyear

Effects of supplementation with fish oil-derived n−3 fatty acids and γ-linole... - 0 views

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    mixture of omega-3 and GLA shown to statistically lower LDL.  The mixture that was statistically significant was 4:2.
Nathan Goodyear

Lipids in Health and Disease | Full text | Omega-3 fatty acids and major depression: A ... - 0 views

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    Omega-3 fatty acids (fish oils) and depression
Nathan Goodyear

Evidence of estrogenic endocrine disruption in smallmouth and largemouth bass inhabitin... - 0 views

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    Is our effect on the environment and the environments, in turn, effect on us politics or science?  It is science that is manipulated by politicians for political gain/power.  In this study of male small/large mouth bass in NE America are found to have significant female characteristics  i.e. eggs where testes should exist...where none should exist.  The numbers were as high as 85% in the small mouth base compared to 27% for the large mouth bass.  Is there any wonder we have a low T epidemic in men?  The most likely cause are endocrine disruptors.  It is a concern that the authors did not look for endocrine disruptors in the water at the time of this study of the fish.
Nathan Goodyear

Potentiation of 17β-estradiol synthesis in the brain and elongation of seizur... - 0 views

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    DHA supplementation increases brain estrogen in animal study. In this study, both blunted seizure induction in the animals. This has significant implications for DHA supplementation and dietary intake of fish high in DHA for the brain through estrogen.
Nathan Goodyear

Dietary habits and prostate cancer detection: a case-control study - 0 views

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    case-control study finds that fish intake is associated with decrease risk of prostate cancer and meat is associated with an increase (3 fold) risk.  
Nathan Goodyear

Alterations in circulating fatt... [JPEN J Parenter Enteral Nutr. 2011] - PubMed - NCBI - 0 views

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    The purpose of this post is not that prednisone should be used to improve the fatty acid profile in those with Lupus.  That is ridiculous.  But, that fatty acid abnormalities are consistently found in Lupus and particularly omega-3 fatty acids should be evaluated.
Nathan Goodyear

A randomised interventional trial of omega-3-p... [Ann Rheum Dis. 2008] - PubMed - NCBI - 0 views

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    Omega-3 supplementation beneficial in patients with Lupus.  This study found a reduction in oxidative stress and endothelial dysfunction
Nathan Goodyear

Oxidant stress, ant... [Prostaglandins Leukot Essent Fatty Acids. 1997] - PubMed - NCBI - 0 views

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    low EPA and DHA found in patients with Lupus.  The authors of this article went so far as to say that lipid peroxides, NO, and anti-oxidants should be a part of the work up for patients with Lupus.
Nathan Goodyear

Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and... - 0 views

  • The results of this study suggest that DHA is the principal 3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans.
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    Omega-3, DHA lowers pressure and heart rate
Nathan Goodyear

Supplementation with fish oil increases first-line chemotherapy efficacy in patients wi... - 0 views

  • supplementation with FO results in increased chemotherapy efficacy without affecting the toxicity profile and may contribute to increased surviva
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    Omega-3 supplementation reduces chemotherapy toxicity and may increase survival
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