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Nathan Goodyear

Breast Cancer Research | Full text | Circulating serum xenoestrogens and mammographic breast density - 0 views

breast-cancer-research.com/...R45

xenoestrogens BPA phthalates women breast cancer

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    study finds increased BPA and phthalates in women is associated with increased breast density.
Nathan Goodyear

Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-Reductase Isozymes in Rat Prostate - 0 views

www.ncbi.nlm.nih.gov/...PMC3566099

bisphenol A Bisphenol-A BPA toxin prostate disease

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    animal model, but Bisphenol A shown to increase aromatase production.  This aids the decreased T:E2 ratio that is commonly found in prostate disease.  So, BPA is a xenoestrogen.  BPA is an androgen receptor antagonist and BPA increases aromatase activity.  
Nathan Goodyear

Patches of Disorganization in the Neocortex of Children with Autism - NEJM - 0 views

www.nejm.org/...NEJMoa1307491

children autism brain

shared by Nathan Goodyear on 01 Apr 14 - No Cached
  • Nathan Goodyear on 01 Apr 14
     
    New study suggests that intra-uterine exposure effects prefrontal cortex development that leads to autism.  This study was conducted of postmortem samples of children with autism ranging from 2 to 15. Intra-pregnancy exposure of what?  That is the question.  Environmental toxins: whether it is all the xenoestrogens (autism at rate of 5:1 in boys), PCBs, heavy metals, and yes (lead author) preservatives, metals (Al and thermeresol) in vaccines--particularly the flu vaccine which ACOG is almost mandating during pregnancy.
Nathan Goodyear

Association between urinary levels of bisp... [Sci Total Environ. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23954212

bisphenol A Bisphenol-A BPA estrogen metabolism hormone hormones xenoestrogens xenoestrogen

shared by Nathan Goodyear on 19 Jun 14 - No Cached
  • Nathan Goodyear on 19 Jun 14
     
    Bisphenol A (BPA) negatively effects estrogen metabolism. Bisphenol A preferentially increases 4OH-estrone which is the most toxic estrogen metabolite.
Nathan Goodyear

PLOS ONE: Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function - 0 views

www.plosone.org/...journal.pone.0051579

Bisphenol-A leydig cells hormone hormones testosterone xenoestrogen

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A decreases testicular testosterone production at the sight of the leydig cells.
Nathan Goodyear

Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.long

ER beta prostate cancer prostate cancer estrogen receptor estrogen receptor receptors hormone hormones

shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    Loss of ER-beta expression in the prostate associated with increased progression from a normal prostate to prostate cancer.
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In Vivo Carcinogenesis in Human Prostate Epithelium - 0 views

www.ncbi.nlm.nih.gov/...PMC3929731

BPA bisphenol A cancer prostate cancer prostate xenoestrogens

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
  • ...13 more annotations...
  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
  • Nathan Goodyear on 20 Apr 16
     
    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
Nathan Goodyear

Common environmental contaminant, cadmium, linked to rapid breast cancer cell growth - 0 views

www.sciencedaily.com/...120423184203.htm

cadmium breast cancer endocrine disruptor xenoestrogen estrogen environmental

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    cadmium increases growth potential of breast cancer.  No surprise, cadmium is a classic endocrine disruptor that mimics estrogen.
Nathan Goodyear

Endocrine Disruptors: From Endocrine to Metabolic Disruption - 0 views

www.bionut.ki.se/...Desvergne.pdf

endocrine disruptors EDC hormone hormones xenoestrogens

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Endocrine disruption starts early due to EDC and effects last life long.
Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats - 0 views

joe.endocrinology-journals.org/...207.abstract

bisphenol A Bisphenol-A BPA xenoestrogens stress hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study - 0 views

www.fertstert.org/...abstract

xenoestrogens phthalates fertility infertility male men toxins

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Study finds phthalate exposure associated with a 20% decline in fertility in men not women.
Nathan Goodyear

Pesticides in Mississippi air and rain:... [Environ Toxicol Chem. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24549493

pesticides farming glyphosate AMPA xenoestrogens environmental toxins

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    Scary stat--75% of samples from air and rainfall taken in delta contaminated with glyphosate and its metabolite AMPA.  These levels were not measured in 1995 so % increase is unable to be determined.  We do know that roundup use has increased dramatically over that time frame.  
Nathan Goodyear

Environmental/lifestyle effects on spermatogenesis - 0 views

rstb.royalsocietypublishing.org/...1697.full

sperm count xenoestrogens EDC endocrine disrupting chemicals endocrine disruptor low T Testosterone men male fertility

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    The environment is playing a role in reduced testicular function in men.
Nathan Goodyear

Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders? - 0 views

cancerpreventionresearch.aacrjournals.org/...897.full

estrogen colon cancer ER beta ER-beta breast

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell proliferation and antagonizing ERα function in the breast
  • HRT with estrogen alone did not increase the risk of breast cancer in the Women's Health Initiative clinical trials program
  • colorectal normal or cancer epithelium does not coexpress ERα and ERβ
  • ...7 more annotations...
  • ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
  • ERβ expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
  • induced ERβ in CRC cells has an antiproliferative, tumor-suppressive function that is independent of ERα
  • ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens and xenoestrogens (or endocrine disruptors)
  • Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
  • Barone et al. recently found that two ERβ-selective phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations of the tumor-suppressor gene adenomatous polyposis coli
  • We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective effect most likely is mediated by ERβ
  • Nathan Goodyear on 19 Nov 13
     
    ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.
Nathan Goodyear

Exposure to DEHP and MEHP from hatching to adu... [Aquat Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24292025

pthalates toxins endocrine disruptors hormones xenoestrogens

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    endocrine disrupting pthalates disrupt marine animal hormones.  This effect was more prevalent in males than females.
Nathan Goodyear

Maternal Cypermethrin Exposure during the Perinatal... [PLoS One. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24810582

EDC endocrine disrupting chemicals xenoestrogens male hormone hormones men Testosterone pregnancy perinatal exposure

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Nathan Goodyear on 12 May 14
     
    another study points to the negative development effects of EDCs.  In this animal study, Cypermethrin exposure in the Perinatal period, disrupts testes development which resulted in decreased Testosterone production in adults.
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

Endocrine actions of pesticides m... [Environ Sci Pollut Res Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25138556

pesticides organophosphates xenoestrogens hormone hormones free T4 TSH sexual development

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  
Nathan Goodyear

PLOS ONE: Persistent Organic Pollutants and Early Menopause in U.S. Women - 0 views

journals.plos.org/...article

EDC endocrine disrupting chemicals women hormone hormones female xenoestrogens endocrine disruptors menopause

shared by Nathan Goodyear on 30 Jan 15 - No Cached
  • Nathan Goodyear on 30 Jan 15
     
    study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.
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