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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Loss of ERβ expression as a common step in estrogen-dependent tumor progression - 0 views

www.ncbi.nlm.nih.gov/...PMC2072930

ER beta hormones ER-beta estrogen receptor estrogen receptor beta ER alpha ER-alpha estrogen cancer tumor carcinogenesis

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    loss of ER-beta expression is associated with increased carcinogenesis, suggesting a protective role for ER-beta against tumor proliferation.
Nathan Goodyear

Estrogen receptor β and the progression of prostate cancer: role of 5α-andros... - 0 views

erc.endocrinology-journals.org/...731.full

ER beta ER-beta hormones prostate cancer cancer 3 beta androstanediol metabolites DHT 3

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  • Nathan Goodyear on 11 Sep 15
     
    Testosterone metabolite 5alpha-androstanedione-3beta,17beta-diol is associated with tumor growth inhibition through ER beta.
Nathan Goodyear

Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.full

ER beta ER-beta prostate cancer prostate cancer estrogen hormones

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  • Nathan Goodyear on 11 Sep 15
     
    loss of ER-beta expression in the prostate is associated with increased prostate carcinogenesis.
Nathan Goodyear

Estrogens and epithelial ovarian cancer - 0 views

www.sciencedirect.com/...S0090825804001994

cancer ovarian cancer ER alpha ER beta ER-alpha ER-beta estrogen hormones

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  • Nathan Goodyear on 11 Sep 15
     
    ER-alpha >ER-beta expression appears to play role in ovarian carcinogenesis.
Nathan Goodyear

Molecular Pathways: Estrogen Pathway in Colorectal Cancer - 0 views

clincancerres.aacrjournals.org/...5842.full

ER beta ER-beta estrogen colon cancer cancer

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  • Nathan Goodyear on 11 Sep 15
     
    ER-beta decreases risk of colon caner.
Nathan Goodyear

Cortisol Measures Across the Weight Spectrum: The Journal of Clinical Endocrinology & M... - 0 views

press.endocrine.org/...JC.2015-2078

cortisol saliva salivary hormones salivary testing saliva testing obesity hormones

shared by Nathan Goodyear on 08 Sep 15 - No Cached
  • Nathan Goodyear on 08 Sep 15
     
    only abstract available.  elevated cortisol associated with the extremes: anorexia and severe obesity.  Mild obesity was associated with low cortisol.
Nathan Goodyear

The what, why and how of aromatase inhibitors: hormonal agents for treatment and preven... - 0 views

www.ncbi.nlm.nih.gov/...PMC2228389

breast cancer aromatase inhibitors aromatase hormones

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  • Nathan Goodyear on 08 Sep 15
     
    aromatase inhibitors and breast cancer.
Nathan Goodyear

Bioidentical Hormones: An Evidence-Based Review for Primary Care Providers - 0 views

jaoa.org/article.aspx

BHRT HRT hormones bio-identical hormones

shared by Nathan Goodyear on 04 Sep 15 - No Cached
  • Nathan Goodyear on 04 Sep 15
     
    Bioidentical hormones (BHRT) preferred over HRT. 
Nathan Goodyear

http://www.biomedcentral.com/content/pdf/1756-0500-3-204.pdf - 0 views

www.biomedcentral.com/...1756-0500-3-204.pdf

DHEA dehydroepiandrostenedione DHEA-S DHEAS hormones saliva salivary hormone salivary hormone testing salivary hormones

shared by Nathan Goodyear on 02 Sep 15 - No Cached
  • Nathan Goodyear on 02 Sep 15
     
    salivary DHEA-S ranges from 4-10 ng/dl in men versus 1-5 in women with no variance between drool or cotton technique.
Nathan Goodyear

Efficacy of quercetin derivatives in prevention of ulcerative colitis in rats : Interdi... - 0 views

www.degruyter.com/...intox-2013-0002.xml

ulcerative colitis UC quercetin inflammation natural

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  • Nathan Goodyear on 02 Sep 15
     
    animal study finds natural quercetin, a flavonoid reduces inflammation in rats with UC.
Nathan Goodyear

Intermediate and Longer-Term Outcomes From a Prospective Active-Surveillance Program fo... - 0 views

jco.ascopubs.org/...JCO.2015.62.5764.full

prostate cancer prostate cancer men

shared by Nathan Goodyear on 02 Sep 15 - No Cached
  • Nathan Goodyear on 02 Sep 15
     
    low aggressive prostate cancer followed conservatively results in low mortality rate in study.  The study is significant in that it followed 1,298 men up to 18 years and found reclassification to "lethal" grade prostate cancer to be only 5.9%.  This challenges long held dogma that the first approach to cancer is to cut it out. For those with low aggressive prostate cancer, conservative approaches i.e. observation, can be employed.
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.long

curcumin DHA TBI traumatic brain injury brain injury neuroinflammation BDNF brain derived neurotrophic factor brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
  • ...10 more annotations...
  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
  • Nathan Goodyear on 31 Aug 15
     
    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

Omega-3 Fats Critical to Brain Health After Traumatic Injury and Surgery - 0 views

www.issfal.org/...r-traumatic-injury-and-surgery

omega 3 omega-3 DHA EPA TBI memory cognition inflammation traumatic brain injury brain injury brain

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  • Nathan Goodyear on 31 Aug 15
     
    Just the press release, but DHA and EPA found to improve nerve cell survival, reduce neuroinflammation and decrease oxidative stress via "resolvins"
Nathan Goodyear

Dietary Supplementation With the Omega-3 Fatty Acid Docosahe... : Neurosurgery - 0 views

journals.lww.com/...with_the_omega_3_fatty.31.aspx

brain injury brain TBI traumatic brain injury DHA

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  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds pre-emptive DHA at 40 mg/kg reduced injury response during medically induced TBI.  Not only can DHA be used with TBI, but this study suggests it can be used in a prevention mode.
Nathan Goodyear

Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves N... - 0 views

www.jneurosci.org/...3743.short

TBI traumatic brain injury brain injury DHA omega 3 omega-3 brain

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  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds DHA aids recovery from TBI.
Nathan Goodyear

Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) - Nutrition and Traumatic Br... - 0 views

www.ncbi.nlm.nih.gov/...NBK209320

TBI traumatic brain injury brain injury omega 3 omega-3 DHA EPA fish oil brain

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  • Nathan Goodyear on 31 Aug 15
     
    Evidence does support that n-3 reduces inflammation; yet limited evidence exists to provide direct evidence that n-3 protects against TBI.
Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.full

BDNF curcumin DHA TBI concussion brain injury traumatic brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • strategies directed to preserve phospholipids in the plasma membrane such as the use of dietary docosahexaenoic acid (C22:6n-3; DHA)5 can have beneficial effects for post-TBI recovery
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain
  • The combination of curcumin and DHA had a trend of greater effects in BDNF (117% of CTL; Figure 1C) compared with DHA or curcumin alone.
  • ...8 more annotations...
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • There was a significant group effect on BDNF (F 4,25 = 5.229, P < .01 by ANOVA), and FPI reduced BDNF levels (50% of CTL, P < .01; Figure 1C), which was counteracted by DHA supplementation (90% of CTL, P < .05; Figure 1C). Curcumin also counteracted this reduction of BDNF
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction.
  • curcumin contributed to enhance the action of DHA, protecting against cognitive impairment, and these effects were associated with elevations in the BDNF receptor signaling
  • Our current results show that curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus.
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • The effects of the DHA diet and curcumin on cognitive enhancement were consistent with enhanced elevations in BDNF receptor signaling
  • effects of DHA and curcumin up to 2 weeks after TBI because this is the most critical period for the course of injury recovery because the brain is metabolically dysfunctional during this time
  • Nathan Goodyear on 30 Aug 15
     
    study that finds curcumin + DHA increased cognitive improvement after TBI within 2 weeks.  Good discussion of the proposed mechanism--increased BDNF.
Nathan Goodyear

ω-3 Fatty Acid Supplementation as a Potential Therapeutic Aid for the Recover... - 0 views

advances.nutrition.org/...268.full

omega 3 DHA EPA fish oil TBI traumatic brain injury concussions concussion brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • There is a growing body of preclinical literature suggesting that ω-3 FAs, and DHA in particular, may play a therapeutic role in mTBI
  • the potential for ameliorating or possibly even preventing the complications associated with concussions
  • DHA is the predominant ω-3 FA present in the brain, and, consistent with this finding, DHA, and not EPA, has been demonstrated to be critical for brain development and cognitive function throughout life
  • ...7 more annotations...
  • the concentration of EPA in the brain is negligible (77–80), suggesting that EPA plays a limited role in mediating the beneficial effects of LCPUFA supplementation on mTBI pathology
  • the current state of the science regarding LCPUFA supplementation for the treatment of concussion is based primarily on animal models
  • there is evidence that the amount of DHA in brain tissue is decreased after mTBI (65, 66), suggesting an elevated need for DHA in mTBI recovery.
  • the well-established role of DHA in supporting the structure and function of the brain throughout the lifespan (26, 27, 46, 47, 53) provides encouragement that LCPUFAs may also prove beneficial in the context of concussion recovery.
  • no therapies are currently available to aid the recovery from this injury
  • Previously discussed reports outlining the use of ω-3 FAs in the recovery from severe TBIs (reviewed in Ref. 92) described the use of very-high doses of LCPUFAs (16.2 g/d EPA plus DHA) in the recovery of these patients
  • Within the context of mTBIs/concussions, translating a DHA intake used in several rat studies of mTBI recovery (40 mg ⋅ kg−1 ⋅ d−1 DHA) (57, 63, 64) using body surface area conversion methods (93) amounts to an estimated human intake of 387 mg/d DHA
  • Nathan Goodyear on 30 Aug 15
     
    nice review of the evidence of n-3, particularily DHA, in concussions and concussion recovery.
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