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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Potential Mechanisms of Estrogen Quinone Carcinogenesis - 0 views

www.ncbi.nlm.nih.gov/...PMC2556295

estrogen metabolites estrogen quinones 4-OH-estrone cancer hormones

shared by Nathan Goodyear on 19 Sep 15 - No Cached
  • 4-hydroxyestrone/estradiol was found to be carcinogenic in the male Syrian golden hamster kidney tumor model, whereas, 2-hydroxylated metabolites were without activity
  • 4-hydroxyestradiol induced uterine tumors in 66% of CD-1 mice; whereas, mice treated with 2-hydroxyestradiol or 17β-estradiol had much lower uterine tumor incidence
  • DNA adducts of catechol estrogen quinones have been detected in the mammary glands of ACI rats treated with 4-hydroxyestradiol or it’s quinone
  • Nathan Goodyear on 19 Sep 15
     
    great read on the proposed mechanisms of how estrogen metabolites produce quinone intermediates that are carcinogenic.
Nathan Goodyear

Estrogen metabolism and breast cancer risk among postmenopausal women: a case-cohort st... - 0 views

www.ncbi.nlm.nih.gov/...PMC3908751

menopause post-menopause breast cancer estrogen metabolites cancer hormone metabolism hormones estrogen

shared by Nathan Goodyear on 18 Sep 15 - No Cached
  • Nathan Goodyear on 18 Sep 15
     
    increased 2 and 4-OH metabolites compared to parent compounds associated with decreased breast cancer in postmenopausal women.
Nathan Goodyear

Circulating Estrogen Metabolites and Risk for Breast Cancer in Premenopausal Women - 0 views

www.ncbi.nlm.nih.gov/...PMC3000741

estrogen metabolites estrogen metabolism estrogen 2-OH-estrone 16-alpha-OH-estrone cancer breast cancer women

shared by Nathan Goodyear on 18 Sep 15 - No Cached
  • Nathan Goodyear on 18 Sep 15
     
    no statistical significant association between 2OH-estrone, 16-alpha-OH-estrone, and their ratio found to be associated with increased breast cancer risk in pre menopause women.
Nathan Goodyear

Investigation of the association between the fecal microbiota and breast cancer in post... - 0 views

www.ncbi.nlm.nih.gov/...26032724

breast cancer women hormones gut flora gut microbiome gut microbiota cancer

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    women with post menopause breast cancer have altered gut flora compared to women without.
Nathan Goodyear

Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC4053199

breast cancer cancer estrogen metabolites 2-OH-estrone 2-hydroxyestrone estrogen

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    Increased metabolism down the 2 hydroxylation pathway appears to reduce postmenopausal breast cancer risk.
Nathan Goodyear

Mucosal Immunology - Molecular signatures of a disturbed nasal barrier function in the ... - 0 views

www.nature.com/...mi20119a.html

S aureus Staphylococcus aureus autoimmune disease disease autoimmune Wegener's granulomatosis WG Wegener's vasculitis

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    nasal mucos colonization of S aureus found to be associated with Wegener's vasculitis as well as relapse.
Nathan Goodyear

Hormonal Regulation of Circulating C-Reactive Protein in Men - 0 views

www.clinchem.org/...911.full

estrogen inflammation CRP men male hormone cytokines

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    High dose of estrogen associated with increase CRP in men.  Definitely a dose dependent response.
Nathan Goodyear

Increased Endogenous Estrogen Synthesis Leads to the Sequential Induction of Prostatic ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2731137

male men hormones estrogen prostatitis inflammation prostate

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    male mouse model finds estrogen can induce prostatitis and dysplasia of the prostate.
Nathan Goodyear

Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views

www.ncbi.nlm.nih.gov/...15215045

estrogen estradiol prostate inflammation cytokines male men hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estradiol induces prostatitis in male rat model.
Nathan Goodyear

Expression of proinflammatory genes during estrogen-induced inflammation of the rat pro... - 0 views

www.ncbi.nlm.nih.gov/...10861753

inflammation IL-1beta IL-6 MIP-2 cytokines prostate estrogen estradiol male hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estrogen increased IL-1beta, IL-6, and MIP-2 in male rat prostate model.
Nathan Goodyear

Association of sex hormones and C-reactive protein levels in men - 0 views

www.ncbi.nlm.nih.gov/...PMC2866020

male men hormones CRP inflammation cytokine Testosterone SHBG estradiol estrogen

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Low total Testosterone, low free Testosterone, and low SHBG associated with increased CRP.  Serum total estradiol and free estradiol trended to a positive association, but did not reach statistical significance.
Nathan Goodyear

Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rhe... - 0 views

www.ncbi.nlm.nih.gov/...14677174

inflammation estradiol estrogen RF RA rheumatoid arthritis men hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estradiol positively associated with RF in men with RA.
Nathan Goodyear

Estradiol and Inflammatory Markers in Older Men - 0 views

www.ncbi.nlm.nih.gov/...PMC2646519

men hormones male hormones estradiol estrogen inflammation IL-6 cytokines CRP TNF-alpha

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Estradiol in men is associated with increased IL-6.  No association was found with CRP or TNF-alpha.
Nathan Goodyear

Association of endogenous sex hormone with C-reactive protein levels in middle-aged and... - 0 views

www.ncbi.nlm.nih.gov/...17302874

inflammation men hormones CRP hsCRP estradiol estrogen Testosterone total Testosterone bioavailable Testosterone

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    total and bioavailable Estradiol associated with increased hsCRP in men age 40-80.  Bioavailable is calculated with serum calculated free Testosterone and albumin bound Testosterone.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2008-0940 - 0 views

press.endocrine.org/...jc.2008-0940

estradiol estrogen men male hormones hormone inflammation IL-6 cytokines

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Estradiol found to be associated with increased IL-6 in older men. This after, the adjustments to exclude variables.  Other inflammatory markers were not associated.
Nathan Goodyear

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insu... - 0 views

stm.sciencemag.org/...304re7

insulin resistance insulin GLUT4 diet nutrition

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Just abstract available, but small study finds men fed high calorie typical in western diets results in GLUT4 inactivation in t think that diet needs a long interval to show effects
Nathan Goodyear

http://cancerres.aacrjournals.org/content/early/2012/01/15/0008-5472.CAN-11-2507.full.pdf - 0 views

cancerres.aacrjournals.org/...0008-5472.CAN-11-2507.full.pdf

estrogen estrogens estrogen metabolites breast cancer cancer hormones

shared by Nathan Goodyear on 12 Sep 15 - No Cached
  • Nathan Goodyear on 12 Sep 15
     
    nice article.  Good discussion on the different effects of the estrogen metabolites on the estrogen receptors and their down stream effects.
Nathan Goodyear

Hormone Therapy, Estrogen Metabolism, and Risk of Breast Cancer in the Women's Health I... - 0 views

www.ncbi.nlm.nih.gov/...PMC3493689

breast cancer estrogen metabolites 2-OH-estrone 2:16 cancer hormones estrogen

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • These results demonstrate that although 16α-OHE1 was increased more by E+P than by E-alone, the increase in the 2:16 ratio was similar for both HT regimens, due to ~4-fold greater increase in 2OHE-1 than 16α-OHE1 for both HT regimens
  • baseline and 1 year change in 16α-OHE1 showed little relationship to incident breast cancer
  • higher baseline 2-OHE1 and the 2:16 ratio were modestly associated with higher odds of incident breast cancer, but larger 1 year increase in 2-OHE-1 and the 2:16 ratio were also weakly associated with lower odds of breast cancer
  • Nathan Goodyear on 11 Sep 15
     
    Good review of the data from the WHI-HT on estrogen metabolites and breast cancer risk.  Increased 2-OHestrone and 2:16 ratio without statistical significance reached.
Nathan Goodyear

CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metab... - 0 views

www.ncbi.nlm.nih.gov/...16949388

estrogen metabolites estrogen metabolism menopause estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    estrogen metabolites and associated risk.
Nathan Goodyear

Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation - 0 views

cebp.aacrjournals.org/...551.long

estrogen metabolism estrogen metabolites cytochrome P450 estrogen estrone hormones detoxification metabolites

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • CYP1A1 and CYP1B1 are not expressed in any significant quantity in the liver. Therefore, they would not be expected to contribute to the overall systemic metabolism of estrone. However, both enzymes have been identified in breast tissue
  • CYP1A1 displayed relatively high activity for all three hydroxylations, suggesting that it may play an important role in extrahepatic tissues where it is expressed
  • CYP1A1 was more active with regard to 2-hydroxylation and 4-hydroxylation, it also displayed one of the greatest 16α-hydroxylating activities of the CYP enzymes tested.
  • ...4 more annotations...
  • CYP1B1 displayed a high affinity for estrone and preferentially catalyzed 4-hydroxylation over 2-hydroxylation
  • CYP1B1 did not seem to contribute to 16α-hydroxylation.
  • CYP1B1 was shown to preferentially catalyze 4-hydroxylation, whereas CYP1A1 was shown to preferentially catalyze 2-hydroxylation
  • Among the CYP enzymes expressed in the liver, CYP1A2 was the most active with regard to 2-hydroxylation
  • Nathan Goodyear on 11 Sep 15
     
    good discussion of estrogen metabolism and the P450 enzymes.
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