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Uric acid and its role in metabolic syndrome.  The elevated uric acid is likely the result of the metabolic dysfunction that leads to metabolic syndrome.

Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%.  The addition of Testosterone therapy increased this % to 81%.

metabolic syndrome incidence in Europe far below that of the US.  One of the primary driving forces of MetS is obesity.

low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.

SHBG decreased in hyperinsulinemic states, such as in metabolic syndrome.  Low Testosterone has proven to be the same, though not looked at in this study.   Also, in this study, low SHBG is associated with increased cardiovascular mortality.

inflammation shown to play a critical role in disease.  Here obesity causes inflammation, but obesity is the result of inflammation.  This then leads to metabolic syndrome, through which disease starts.

Great pictorials of the biochemistry of metabolic syndrome.

correlation of low adiponectin and metabolic syndrome is higher in women than men.

Inflammation, TNF-alpha and IL-1B, reduces testosterone production.  Metabolic Syndrome, an inflammatory disease, shown to be associated low Testosterone.

LC-MS/MS shown to be reliable in salivary cortisol evaluation.  Obese individuals create special challenges with regards to coritsol levels, due to peripheral cortisol to cortisone conversion.   This study points out that saliva should not be used solely in the diagnosis of Cushing's syndrome due to unreferenced norms.   That however, doesn't nullify salivary cortisol.  It requires a look at the references.  for those that are obese and being evaluated for cushing's.  There is no perfect test.  T This study is a little misleading in its conclusion.  Salivary testing is valid, but the reference ranges in the obese with suspected cushing's syndrome needs further evaluation: according to these authors.

Got metabolic syndrome: get alittle nutty, or just eat nuts.

Testosterone replacement found to reduce inflammation (Il-1B, TNF-alpha, and CPR) in men with metabolic syndrome.  Testosterone was also shown to reduce insulin and leptin as well.

Article reviews the link between obesity, low T, metabolic syndrome and ED.  ED has been shown to be predictive of CVD by 3-5 years.  

This study found that increasing Testosterone, as determined by serum, is associated with increased CVD, insulin resistance, and metabolic syndrome in postmenopausal women.  I believe that this massive Testosterone doping campaign that we are seeing in men and women is following the same patter seen with premarin and provera. 

Total Testosterone and SHBG inversely associated with Metabolic Syndrome.

Study finds Total Testosterone and SHBG inversely associated with Metabolic Syndrome.  Free Testosterone and BMI were positively associated with MetS.

Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.

Metabolic syndrome associated with increased risk of ED in men in meta-analysis.  This points to ED as a metabolic condition.

Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.

Abstract presented finds that Testosterone IM undecanoate significantly reduced metabolic syndrome parameters in men.  This study looked at men with secondary hypogonadism and late onset.  The ages were from 15-72.  The full is not available as of this post.  The study only looked at serum T.  This limits the usefulness of this test.  According to this abstract, no evaluation of SHBG was performed.  Though not significant, PSA and prostate volume increased.