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Nathan Goodyear

BMC Endocrine Disorders | Full text | The prevalence of metabolic syndrome and metaboli... - 0 views

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    metabolic syndrome incidence in Europe far below that of the US.  One of the primary driving forces of MetS is obesity.
Nathan Goodyear

Oestrogen and colorectal cancer: mechan... [Int J Colorectal Dis. 2013] - PubMed - NCBI - 0 views

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    Estrogen early protects against colon cancer, but estrogen increases proliferation late.  The problem here is the estrogens involved.  If ER beta is shown to be highly expressed in the colon, then Estriol would be of benefit as it preferentially binds to ER beta at a rate of 5:1 and Estradiol at a rate of 1:1.  Estriol is currently used in Europe in advanced breast cancer.
Nathan Goodyear

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women - 0 views

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    hormone levels in women fluctuate.  Saliva testing used to evaluate hormone fluctuations.  Published in Journal of Endocrinology of Europe
Nathan Goodyear

Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor,... - 0 views

  • the MAF precursor activity of prostate cancer patient Gc protein is lost or reduced, because their serum Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells
  • Administration of 100 ng of GcMAF
  • 100 ng of GcMAF was administered intramuscularly once a week
  • ...11 more annotations...
  • As GcMAF therapy progressed the MAF precursor activity of all five patients increased and their serum Nagalase activity decreased inversely
  • As GcMAF therapy progressed, the MAF precursor activity increased with a concomitant decrease in serum Nagalase activity
  • serum Nagalase is proportional to tumor burden
  • as GcMAF therapy progressed, serum Nagalase activity decreased and, concomitantly, tumor burden decreased
  • the serum Nagalase activities of all 16 patients decreased as GcMAF therapy progressed
  • annual computed tomographic scans of these patients confirmed them being tumor recurrence-free for the 7 years
  • undifferentiated cells were killed rapidly during the first few weeks, and the differentiated cells were killed slowly in the remaining GcMAF therapeutic period
  • PSA levels of prostatectomized patients decreased as serum Nagalase decreased during GcMAF therapy
  • In patients without tumor resection, however, although serum Nagalase activity decreased as GcMAF therapy progressed, their PSA values remained unchanged. The result suggests that the PSA derived from tumor-bearing prostate did not change while tumor burden decreased. Because tumor-induced inflammation in the noncancerous prostate tissues causes secretion of PSA [38], the PSA produced from these inflamed noncancerous prostate tissues cannot be changed by the decrease in tumor burden
  • Advanced cancer patients have high serum Nagalase activities, resulting in no macrophage activation and severe immunosuppression that explain why cancer patients die with overwhelming infection
  • Prognostic utility of serum α-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients
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    GC-MAF levels exist in inverse relationship to nagalase.  In this study of men with prostate cancer, weekly GCMAF injections reduced Nagalase activity to levels found in healthy controls suggesting tumor free. The dose was 100 ng/week. Nagalase is a protein that suppresses GC-MAF production and thus is immunosuppressive.
Nathan Goodyear

https://academic.oup.com/DocumentLibrary/humupd/PR/dmx022_final.pdf - 0 views

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    The problem of male infertility continues to grow. New study finds that from 1973 to 2011, sperm count among men in North America, Europe, Australia, and New Zealand drop by 50-60%.
Nathan Goodyear

Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin ... - 0 views

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    study on melatonin and IL2 in cancer
Nathan Goodyear

Sugary drink consumption and risk of cancer: results from NutriNet-Santé pros... - 0 views

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    New study out of Europe finds that consumption of "sugary" drinks positively correlates with overall cancer risk and breast cancer risk.
Nathan Goodyear

Cardiovascular disease in Europe: epidemiological update 2016 | European Heart Journal ... - 0 views

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    Cancer will soon overtake cardiovascular disease as the #1 cause of mortality in the US and worldwide as happened in 12 European countries. The current dogma for cancer treatment is not working; the goal must be prevention. The 12 countries include: Spain, France, Belgium, Denmark, Italy, Israel, Luxembourg, The Netherlands, Norway, Portugal, Slovenia, and UK.
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indian-health

Best Hospitals for Urethroplasty Surgery India Redefining the Standards of Urology Care! - 0 views

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    Most patients from Europe, USA and UK travel to best hospitals for urethroplasty surgery India due to the low Cost of Urethroplasty Surgery India.
indian-health

Top 10 Urethroplasty Surgeons of India Offering Specialized Care For Urology Health - 0 views

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    Most patients from Europe, USA and UK travel to get treated by top 10 urethroplasty surgeons of India due to the cheapest pricing alternatives of treatment in India.
Nathan Goodyear

Common genetic variation in the IGF1 associates with maximal force output. - Abstract -... - 0 views

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    genetic variations effect the bodies ability to build muscle through protein metabolism. 
Nathan Goodyear

[Hormonal changes in fertile women with quiescent systemic lupus erythematosus] - Abstr... - 0 views

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    Abstract suggests that low progesterone plays a role in Lupus.
Nathan Goodyear

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits po... - 0 views

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    vitamin D decreased fibrogenesis in invivo mouse model of scleroderma.
Nathan Goodyear

Androgenicity and venous endothelial function in post-menopausal women. - Abstract - Eu... - 1 views

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    Increasing free androgen index associated with increasing vascular endothelial inflammation and dysfunction.
Nathan Goodyear

[Plasma testosterone, obesity, metabolic syndrome and diabetes]. - Abstract - Europe Pu... - 0 views

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    Androgen deprivation therapy leads to insulin resistance, metabolic syndrome, and type II diabetes in men. Testosterone therapy in men with IR, obesity, metabolic syndrome, and type II Diabetes will result in improved cardiovascular risk.  
Nathan Goodyear

Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estro... - 0 views

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    Estradiol upregulates tryptophan hydroxylase and thus serotonin production.  The signaling was via ER beta and estrogen response elements.
Nathan Goodyear

Sex hormone binding globulin, but not testosterone, is associated with the metabolic sy... - 0 views

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    This study finds an association between low SHBG and increased metabolic syndrome in obese women with PCOS.  Testosterone was not associated.  Other studies have shown a positive association between Testosterone and MetS in women.  This follows men in that SHBG shows an association with MetS.  Only the abstract is present here, so I can't look at the data presented.
Nathan Goodyear

Expression of estrogen receptor beta in colon cancer progression. - Abstract - Europe P... - 0 views

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    ER beta expression is dominant in healthy colon epithelium.  This study found that as colon disease progressed, ER beta expression declined.  So that, early disease was associated with the highest level of ER beta expression.
Nathan Goodyear

Topical lavender oil for the treatment of recurrent aphthous ulceration. - Abstract - E... - 0 views

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    Topical lavender reduced aphthous ulcers in animal study.
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