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Nathan Goodyear

http://news.medlive.cn/uploadfile/20130922/13798433918223.pdf - 0 views

news.medlive.cn/...13798433918223.pdf

ED erectile dysfunction beta blockers medications

shared by Nathan Goodyear on 27 Sep 15 - No Cached
  • Nathan Goodyear on 27 Sep 15
     
    Study finds that Beta-1 selective Beta blockers don't have the same ED effects that the non-selective blockers do.
Nathan Goodyear

Thiazide Diuretics Alone or with Beta-blockers Impair Glucose Metabolism in Hypertensiv... - 0 views

www.ncbi.nlm.nih.gov/...PMC2796286

hypertension HCTZ thiazide diuretics beta blockers

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Nathan Goodyear on 13 Sep 17
     
    thiazide diuretics and beta blockers impair glucose metabolism; mechanism of action not exactly known.
Nathan Goodyear

Erectile dysfunction in high-risk hypertensive patients treated with beta-blockade agen... - 0 views

www.ncbi.nlm.nih.gov/...20074255

erectile dysfunction ED beta blockers medications hypertension

shared by Nathan Goodyear on 27 Sep 15 - No Cached
  • Nathan Goodyear on 27 Sep 15
     
    Beta blocker therapy appears to be associated with ED in patients with hypertension.
Nathan Goodyear

Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and ... - 0 views

www.ncbi.nlm.nih.gov/...12107602

beta blockers medications sexual dysfunction Testosterone men hormones low t low Testosterone

shared by Nathan Goodyear on 27 Sep 15 - No Cached
  • Nathan Goodyear on 27 Sep 15
     
    Beta blocker therapy resulted in decreased sexual activity and serum Testosterone levels compared to AARB therapy.
Nathan Goodyear

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction - NEJM - 0 views

www.nejm.org/...NEJMoa055227

NORVIT trial homocysteine vitamin B12 B6 folic acid CVD cardiovascular disease MI stroke strokes events

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

mitochondria oxidative stress heart failure heart

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
      Nathan Goodyear on 19 Mar 13
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
  • Nathan Goodyear on 19 Mar 13
     
    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
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