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Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

www.nature.com/...ncpendmet1050.html

low T Testosterone health men male hormone hormones metabolic syndrome metabolic syndrome MetS insulin resistance diabetes aging

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
  • ...18 more annotations...
  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
  • Nathan Goodyear on 03 Mar 14
     
    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Effect of 12 weeks of periodized resistance training upon total plasma adiponectin conc... - 0 views

www.ncbi.nlm.nih.gov/...26274372

resistance training exercise aerobic exercise adiponectin

shared by Nathan Goodyear on 18 Aug 15 - No Cached
  • Nathan Goodyear on 18 Aug 15
     
    balance: exercise is no different. Cardio plus resistance training increases adiponectin over resistance training alone.
Nathan Goodyear

Insulin resistance and Alzheimer's disease. [BMB Rep. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19712582

alzheimer's disease insulin resistance neurodegenerative

shared by Nathan Goodyear on 20 Feb 11 - No Cached
  • there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.
  • Nathan Goodyear on 20 Feb 11
     
    Insulin resistance has dual mechanism of contribution to Alzheimer's disease
Nathan Goodyear

Metabolic syndrome and insulin resistance in Divis... [Med Sci Sports Exerc. 2009] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...19915510

metabolic syndrome insulin resistance college football lineman

shared by Nathan Goodyear on 14 May 11 - No Cached
  • Linemen are at significant risk for metabolic syndrome and insulin resistance compared with other positions. This may be predictive of future health problems in Division 1 collegiate football players, especially linemen
  • There is a strong association between obesity and both metabolic syndrome and insulin resistance in Division 1 collegiate football players
  • Nathan Goodyear on 14 May 11
     
    college football lineman at increased risk of obesity, insulin resistance, and future health problems
Nathan Goodyear

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier - 0 views

diabetes.diabetesjournals.org/...1253.full

leptin resistance triglycerides

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Obesity is associated with leptin resistance
  • Resistance arises from impaired leptin transport across the blood-brain barrier (BBB)
  • Decreasing triglycerides may potentiate the anorectic effect of leptin by enhancing leptin transport across the BBB.
  • ...2 more annotations...
  • Starvation, like obesity, is accompanied by a decreased BBB transport rate of exogenous leptin
  • hypertriglyceridemia could explain impaired transport of leptin across the BBB in both starvation and obesity
  • Nathan Goodyear on 12 Apr 11
     
    elevated triglycerides and leptin resistance
Nathan Goodyear

Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4523075

LPS lipopolysaccharides leptin CCK cholecystokinin metabolism weight appetite diet nutrition inflammation

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Obesity and models of obesity induced by ingestion of HF-diet in rodents are associated with chronically elevated circulating levels of LPS
  • chronic low-dose administration of LPS induces leptin-resistance in vagal afferent neurons and abolition of CCK-induced inhibition of food intake
  • HF fat feeding has been shown to enhance gastrointestinal permeability promoting the translocation of LPS to the circulation
  • ...9 more annotations...
  • LPS leads to an increase in SOCS3 expression [20]. SOCS3 is a negative regulator of leptin signaling
  • We observed a significant increase in energy intake in the LPS-treated rats
  • the data provides a mechanism linking changes in gut microbiota induced by ingestion of HF diets to dysregulation of food intake and body weight
  • Chronic low-dose LPS treatment induced TLR4 activation and MyD88 signaling in vagal afferent neurons, associated with increased SOCS3 expression and reduced leptin-signaling, characterized by the absence of leptin-induced pSTAT3.
  • SOCS3 is an important mechanism by which leptin resistance develops in vagal afferent neurons and coincides with the onset of hyperphagia
  • We demonstrate that this chronic low dose LPS is sufficient to induce leptin–resistance in vagal afferent neurons, reduced sensitivity to the satiating effects of CCK, and loss of vagal afferent plasticity
  • it suggests that the increase in food intake and body weight we observed at week 6 in the LPS treated rats may be caused by LPS-induced leptin resistance.
  • chronic LPS treatment of mice for four weeks increased body weight
  • chronic LPS treatment of mice for four weeks increased subcutaneous fat
  • Nathan Goodyear on 04 Oct 17
     
    Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.
Nathan Goodyear

JCI - Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mu... - 0 views

www.jci.org/115225

thyroid hormone resistance thyroid hormone resistance syndrome

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Thyroid hormone resistance is not a new term.  This study goes back to 1991.
Nathan Goodyear

Cardiac Involvement in Thyroid Hormone Resistance - 0 views

jcem.endojournals.org/...204.abstract

thyroid hormone resistance thyroid hormone resistance cardiac heart

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Thyroid hormone resistance has cardiac effects.
Nathan Goodyear

Effects of androgens on insulin actio... [Diabetes Metab Res Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18615851

insulin resistance androgen testosterone DHT DHEA women PCOS hormones hormone

shared by Nathan Goodyear on 17 Oct 12 - No Cached
  • Nathan Goodyear on 17 Oct 12
     
    elevated insulin associated with insulin resistance causes elevated male hormones in women.  Whether it is in PCOS or postmenopausal over-aggressive replacement, Testosterone also turns right around and contributes to insulin resistance.  Vicious cycle.
Nathan Goodyear

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-relate... - 0 views

www.ncbi.nlm.nih.gov/...21442412

curcumin polyphenols obesity diabetes lipids inflammation leptin resistance adiponectin

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Review article of Curcumin, a polyphenol, reduces insulin resistance, leptin resistance,  elevated glucose levels, elevated lipids, and inflammation in obesity and metabolic dysfunction.  Adiponectin levels were increased.
Nathan Goodyear

Is strength training associated with mortality benefits? A 15year cohort study of US ol... - 0 views

www.sciencedirect.com/...S0091743516300160

strength training resistance training mortality elderly exercise health

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    resistance training is not just for the young; new study finds that resistance training in those > 65 reduced all-cause mortality odds.
Nathan Goodyear

Variations in urine excretion of steroid hormones after an acute session and after a 4-... - 0 views

link.springer.com/...10.1007%2Fs00421-006-0319-1

androgens Testosterone resistance training exercise male hormones

shared by Nathan Goodyear on 14 Feb 17 - No Cached
  • Nathan Goodyear on 14 Feb 17
     
    4 week resistance training program found to increase androgens in urine; this suggests increased androgen production as a result of the resistance program
Nathan Goodyear

Diabetologia, Volume 46, Number 5 - SpringerLink - 0 views

www.springerlink.com/...4tupvdmkjf2lyu6l

obesity overweight women pre-menopausal inflammation IL-6 CRP insulin resistance IR

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Nathan Goodyear on 10 May 12
     
    This study finds obesity associated with inflammation, but insulin resistance not.  But insulin resistance contributes to obesity...
Nathan Goodyear

Testosterone Concentrations in Women and Men With NIDDM - 1 views

care.diabetesjournals.org/...405.short

testosterone T men women insulin resistance IR type II DM diabetes

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    insulin resistance has different effects in men versus women.  In men, insulin resistance is associated with low T in men, but in elevate T in women.
Nathan Goodyear

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity - 0 views

ajpendo.physiology.org/...E1465.long

cortisol insulin resistance metabolic syndrome obesity overweight

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • acute GC secretion during stress mobilizes peripheral amino acids from muscle as well as fatty acids and glycerol from peripheral fat stores to provide substrates for glucose synthesis by the liver
  • chronically elevated GC levels alter body fat distribution and increase visceral adiposity as well as metabolic abnormalities in a fashion reminiscent of metabolic syndrome
  • This local production may play an important role in the onset of obesity and insulin resistance.
  • ...9 more annotations...
  • In adipocytes, cortisol inhibits lipid mobilization in the presence of insulin, thus leading to triglyceride accumulation and retention.
  • Since the density of GC receptors is higher in intra-abdominal (visceral) fat than in other fat depots, the activity of cortisol leading to accumulation of fat is accentuated in visceral adipose tissue (24, 158), providing a mechanism by which excessive endogenous or exogenous GC lead to abdominal obesity and IR
  • obese patients generally have normal or subnormal plasma cortisol concentrations
  • This may be explained by an increased intratissular/cellular concentration of cortisol in adipose tissues
  • Intracellular GC may be produced from recycling of GC metabolites such as cortisone in adipose tissues
  • Local GC recycling metabolism is mediated by 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2
  • Cortisol also increases 11β-HSD1 expression in human adipocytes
  • In humans, elevated 11β-HSD1 expression in visceral adipose tissue is also associated with obesity
  • even if obese patients generally have normal or subnormal plasma cortisol concentrations (131, 158), triglyceride accumulation in visceral adipose tissue may be due, at least in part, to the local production of GC in insulin- and GC-responsive organs such as adipose tissue, liver, and skeletal muscle
  • Nathan Goodyear on 14 Mar 12
     
    another nice article on the dysregulation of cortisol and its role in insulin resistance, metabolic syndrome, and obesity.
Nathan Goodyear

Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resis... - 0 views

press.endocrine.org/...jc.2009-0740

testosterone metabolic syndrome insulin resistance metabolic syndrome insulin resistance CVD cardiovascular disease hormone hormones women

shared by Nathan Goodyear on 25 Feb 14 - No Cached
  • Nathan Goodyear on 25 Feb 14
     
    This study found that increasing Testosterone, as determined by serum, is associated with increased CVD, insulin resistance, and metabolic syndrome in postmenopausal women.  I believe that this massive Testosterone doping campaign that we are seeing in men and women is following the same patter seen with premarin and provera. 
Nathan Goodyear

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Re... - 0 views

care.diabetesjournals.org/...1809.full

LPS dysbiosis dyslipidemia insulin resistance cholesterol lipids obesity insulin resistance inflammation IR

shared by Nathan Goodyear on 19 Jul 13 - No Cached
  • Nathan Goodyear on 19 Jul 13
     
    LPS linked to dsylipidemia, insulin resistance, obesity, and chronic inflammation.
Nathan Goodyear

JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC3835653

JNK inflammation obesity insulin resistance insulin resistance

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    JNK pathway plays important role in inflammation signaling.  In this article, JNK activation plays role in insulin resistance, obesity, and metabolic dysfunction.
Nathan Goodyear

Nutritional Modulation of Insulin Resistance - 0 views

www.hindawi.com/...424780

macronutrient macronutrients nutrition insulin resistance glucose protein carbohydrates metabolism fats

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Five branched chain and aromatic amino acids (isoleucine, leucine, valine, tyrosine, and phenylalanine) showed significant associations with future diabetes
  • there is increasing evidence that longer term high-protein intake may have detrimental effects on insulin resistance [68, 117–123], diabetes risk [69], and the risk of developing cardiovascular disease
  • high-protein and the high GI diets significantly increased markers of low-grade inflammation
  • ...5 more annotations...
  • significant and clinically relevant worsening of insulin sensitivity with an isoenergetic plant-based high-protein diet
  • healthy humans that are exposed to amino acid infusions rapidly develop insulin resistance
  • longer term high-protein intake has been shown to result in whole-body insulin resistance [68, 118], associated with upregulation of factors involved in the mammalian target of rapamycin (mTOR)/S6K1 signalling pathway [68], increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover [118] and stimulation of gluconeogenesis [68, 118].
  • it was recently shown in a large prospective cohort with 10 years followup that consuming 5% of energy from both animal and total protein at the expense of carbohydrates or fat increases diabetes risk by as much as 30% [69]. This reinforces the theory that high-protein diets can have adverse effects on glucose metabolism.
  • Another recent study showed that low-carbohydrate high-protein diets, used on a regular basis and without consideration of the nature of carbohydrates or the source of proteins, are also associated with increased risk of cardiovascular disease [70], thereby indicating a potential link between high-protein Western diets, T2DM, and cardiovascular risk.
  • Nathan Goodyear on 21 Oct 13
     
    macronutrient intake and effect on glucose regulation and thus metabolism.
Nathan Goodyear

ScienceDirect - Trends in Immunology : Inflammation: the link between insulin resistanc... - 0 views

www.sciencedirect.com/science

inflammation obesity insulin resistance diabetes

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • Inflammation: the link between insulin resistance, obesity and diabetes
  • Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations of TNF-α and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction. This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
  • Nathan Goodyear on 09 Mar 11
     
    Inflammation: the link between insulin resistance, obesity and diabetes
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