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Nathan Goodyear

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in... - 0 views

www.ncbi.nlm.nih.gov/...26950683

low T low Testosterone Testosterone prostate men male hormones PSA LUTS aromatase aromatase inhibition

shared by Nathan Goodyear on 08 Mar 16 - No Cached
  • Nathan Goodyear on 08 Mar 16
     
    study finds both Testosterone therapy and aromatase inhibition in men > 65 both increase Testosterone levels.  Increase in prostate size was only seen in the Testosterone only group; not in the AI group.  This implicates aromatase activity in the increase in prostate volume.  
Nathan Goodyear

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate ... - 0 views

www.ncbi.nlm.nih.gov/...26589415

prostate cancer prostate cancer Testosterone SHGB men male hormones

shared by Nathan Goodyear on 09 Dec 15 - No Cached
  • Nathan Goodyear on 09 Dec 15
     
    study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer.  Included: no association with SHBG and estrogen to Testosterone ratio.
Nathan Goodyear

Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate pot... - 0 views

onlinelibrary.wiley.com/...pros.22562

cancer virus prostate cancer EBV HPV Epstein-Barr virus human papilloma virus

shared by Nathan Goodyear on 03 Oct 18 - No Cached
  • Nathan Goodyear on 03 Oct 18
     
    Is prostate cancer the result of viral infection.  Study suggests HPV and EBV play a role.
Nathan Goodyear

High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Fa... - 0 views

www.ncbi.nlm.nih.gov/...PMC4344236

prostate cancer progesterone progesterone receptor hormones cancer prostate

shared by Nathan Goodyear on 03 Jun 18 - No Cached
  • Currently, there is a general agreement of PGR presence in the stromal cells of PCa
  • expressed in both stromal and tumor cells of the PCa tissue
  • In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
  • ...17 more annotations...
  • High density level of PGR in the TE was an independent prognostic factor for CF.
  • Our large-sized study demonstrates a wide distribution of PGR in stromal and epithelial cells of both benign and malignant prostate tissue
  • there seems to be a general agreement of PGR presence in the stromal cells of PCa
  • In line with our findings, several have also reported a high PGR expression in TE of PCa [9,10,23,25]. In contrast, others have demonstrated a total lack of PGR expression in TE
  • the actions of progesterone are tissue specific
  • In our work univariate analysis demonstrated a high PGR expression in TS to be associated with clinical failure in PCa patients. So far we have not yet demonstrated the mechanism underlying this association
  • Several non-genomic proliferative actions of progesterone have been proposed in tumor cells of other organs, including breast [35–37], astrocytoma [38] and osteosarcoma [39] cell lines. However, such results are contradicted by suggestions of anti-proliferative actions of progesterone in endometrial cancer
  • Yu et al. found PGR to be negatively regulating stromal cell proliferation in vitro
  • high PGR density level in TE was associated with CF in patients with Gleason score ≥ 7
  • Bonkhoff et al. have suggested progressive emergence of PGR during PCa progression and metastasis
  • Latil and co-workers found a decreased PGR expression in clinically localized tumors and increased PGR expression in hormone-refractory tumors, when compared with normal prostate tissue
  • Our findings provide further support to these findings, indicating that PGR plays a role in the pathogenesis of PCa
  • Ki67 and PGR in TE were correlated with CF (S3 Text), indicating an association between PGR and proliferative activity
  • The mechanism behind the PGR up-regulation in PCa has not yet been elucidated
  • The PGR is, like the glucocorticoid receptor, similar to androgen receptor with 88% sequence homology in the ligand-binding domain
  • progesterone induced expression of androgen receptor-regulated genes could be a potential mechanism contributing to the development of castrate resistant PCa
  • A possibility of different roles by the two PGR isoforms in normal prostate tissue and PCa, as is suggested for the estrogen receptors [13], must also be taken into account
  • Nathan Goodyear on 03 Jun 18
     
    STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy.  Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Fat Intake After Diagnosis and Risk of Lethal P... - 0 views

archinte.jamanetwork.com/article.aspx

fat vegetable cancer prostate carbs carbohydrates diet

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    Carb reduction and increase in vegetable fat appears to be associated with reduction in prostate cancer spread and all-cause mortality
Nathan Goodyear

Taylor & Francis Online :: Dietary Patterns as Predictors of Prostate Cancer in Jamaica... - 0 views

www.tandfonline.com/...01635581.2013.757631

prostate cancer prostate cancer sugar refined carbohydrates nutrition

shared by Nathan Goodyear on 02 Jul 13 - No Cached
  • Nathan Goodyear on 02 Jul 13
     
    No surprise here, highest refined sugar intake associated with increased risk of Prostate Cancer.
Nathan Goodyear

A new approach to prostate cancer. [J Pharm Pharmacol. 1989] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2570857

progesterone hormones 5alpha reductase prostate cancer prostate cancer

shared by Nathan Goodyear on 08 Jul 13 - No Cached
  • Nathan Goodyear on 08 Jul 13
     
    Progesterone is proposed as a therapy in prostate cancer.   The mechanism is due to the inhibition of 5alpha reductase activity.
Nathan Goodyear

Induction at high incidence of ductal prostate adenocarcinomas in NBL/Cr and Sprague-Da... - 0 views

www.ncbi.nlm.nih.gov/...7788848

prostate prostate cancer estrogen men estradiol male hormones Testosterone hormones

shared by Nathan Goodyear on 18 Nov 16 - No Cached
  • Nathan Goodyear on 18 Nov 16
     
    Adding Estradiol to Testosterone in rate model significantly increases prostate carcinogenesis in rat model.
Nathan Goodyear

Estrogen receptors alpha and beta in the normal, hyperplastic and carcinomatous human p... - 0 views

joe.endocrinology-journals.org/...447

ER-alpha ER-beta inflammation prostatitis BPH prostate cancer hyperplasia

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    ER alpha and ER beta receptors play role in BPH and prostate cancers.  ER alpha is proliferative and inflammatory: ER beta is inhibitory.
Nathan Goodyear

Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase express... - 0 views

joe.endocrinology-journals.org/...89.full

prostate BPH PGE2 inflammation men male hormone hormones aromatase estradiol estrone stroma

shared by Nathan Goodyear on 19 Sep 12 - No Cached
  • Nathan Goodyear on 19 Sep 12
     
    Increased aromatase activity is found in BPH.  PGE2 increases aromatase activity and thus increases Estradiol production in the stroma of the prostate.
Nathan Goodyear

Estrogen receptor-β: Implications for the prostate gland - Chang - 1999 - The... - 0 views

onlinelibrary.wiley.com/...abstract

ER beta ER-beta prostate cancer estrogen receptor receptors

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    ER beta and the prostate.  Older review.
Nathan Goodyear

An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and... - 0 views

www.pnas.org/...13589.long

prostate 3-beta androstanediol ER beta ER-beta cancer estrogen

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    Great discussion of how 5alpha-androstane-3beta, 17beta-androstanediol interacts with ER beta as an estrogen to inhibit proliferation of the prostate and carcinogenesis.
Nathan Goodyear

Elevated androgens and prolactin in aromatase-... [Endocrinology. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11356695

prostate cancer hormone hormones androgens Testosterone DHT estrogens male men BPH

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    aromatase knockout mice, thus elevated androgens without estrogen production, develop BPH but not prostate cancer.  This points to estrogen as the important hormone in carcinogenesis of the prostate. Granted this is a animal model.
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826

prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

http://eu-acme.org/europeanurology/upload_articles/Bonkhoff.pdf - 0 views

eu-acme.org/...Bonkhoff.pdf

estrogen estradiol ER receptors ER alpha ER beta prostate cancer male men hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached
  • Nathan Goodyear on 20 Jan 14
     
    Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression.  As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."
Nathan Goodyear

Persistent Intraprostatic Androgen Concentrations after Medical Castration in Healthy M... - 0 views

press.endocrine.org/...jc.2006-0968

Testosterone androgen deprivation therapy prostate cancer men male hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Serum Testosterone levels and intra-prostatic Testosterone levels in men are very different in men with androgen deprivation therapy.  Though there is a 94% serum reduction, intra-prostatic Testosterone levels remain 20-30% higher.  
Nathan Goodyear

Correlation between circulatory, local prostatic, a... [Prostate. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21541968

prostate DHT hormone hormones men male metabolite metabolites

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    No correlation was found between intra-prostate DHT and serum DHT levels.  Why do we continue to use serum?  This article also touches on the metabolites of DHT.
Nathan Goodyear

Annals of Internal Medicine | Long-Term Effects of Dihydrotestosterone Treatment on Pro... - 0 views

annals.org/article.aspx

DHT dihydrotestosterone prostate men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    DHT at 70 mg daily shown to have no adverse effects in the prostate of "healthy" men older than 50.  However, it did increase DHT metabolites (3 alpha androstane-diol and 3 beta androstane-diol), decreased LH, Testosterone, Estradiol, FSH, increased hemoglobin, creatinine, lean mass and decreased fat.
Nathan Goodyear

Actions of Estrogens and Endocrine Disrupting Chemicals on Human Prostate Stem/Progenit... - 0 views

www.ncbi.nlm.nih.gov/...PMC3249013

prostate cancer EDC xenoestrogens endocrine disrupting chemicals estrogen men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Endocrine Disrupting chemicals, xenoestrogens, alter the hormone receptors very early. Increased estrogenic load with the change in ER increase prostate cancer.
Nathan Goodyear

Serum testosterone improves the accuracy of Pro... [Clin Biochem. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24530341

Testosterone prostate cancer

shared by Nathan Goodyear on 19 Feb 14 - No Cached
  • Nathan Goodyear on 19 Feb 14
     
    I think the authors missed the points to be taken from their research:prostate cancer patients had "lower concentrations of total Testosterone, free Testosterone, and bioavailable Testosterone" versus controls that were prostate cancer free.  This provides additional support that prostate cancer is not a androgen driven disease.
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