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Nathan Goodyear

Effect of high dose vitamin C on Epstein-Barr viral infection - 0 views

www.ncbi.nlm.nih.gov/...PMC4015650

IVC IV intravenous vitamin C IV vitamin C intravenous vitamin C vitamin C Epstein-Barr Epstein-Barr virus EBV viral infection

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    IV vitamin C shown to reduce EBV EA IgG and EBV VCA IgM using 7.5 grams to 50 gram infusions.  This protocol found that Magnesium reduced discomfort with the IVC therapy.
Nathan Goodyear

Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC7551554

glutathione peroxidase SOD superoxide disumutase cancer glutathione

shared by Nathan Goodyear on 07 Jun 23 - No Cached
  • Nathan Goodyear on 07 Jun 23
     
    Hmmm…."Both GPx and SOD activity was statistically lower in patients with EBV/HPV coinfection than in a single EBV or HPV infection. Analysis of GPx and SOD activity in relation to histological grading and tumor, node (TN) classification revealed that in poorly-differentiated tumors, the level of antioxidant enzymes was lower compared with well-differentiated lesions and in cases with greater tumor dimensions and lymph-node involvement, both GPx and SOD activity was decreased."
Nathan Goodyear

Epstein-Barr Virus (EBV) Infections in Patients - 0 views

orthomolecular.org/...1996-v11n04-p208.pdf

EBV mono Epstein-Barr virus vitamin C IV vitamin C

shared by Nathan Goodyear on 20 May 13 - No Cached
  • Nathan Goodyear on 20 May 13
     
    Case studies that used high dose IV vitamin C to treat EBV.
Nathan Goodyear

World Journal of Virology-Baishideng Publishing - 0 views

www.wjgnet.com/...31.htm

EBV Mono Epstein-Barr Virus titers EBV titers

shared by Nathan Goodyear on 15 Apr 13 - No Cached
  • Nathan Goodyear on 15 Apr 13
     
    Great review on EBV titers and what they mean.
Nathan Goodyear

HUMAN VIRAL ONCOGENESIS: A CANCER HALLMARKS ANALYSIS - 0 views

www.ncbi.nlm.nih.gov/...PMC3992243

EBV Epstein-Barr virus cancer oncovirus HBV HCV HIV HPV

shared by Nathan Goodyear on 18 Dec 17 - No Cached
  • pproximately twelve percent of all human cancers are caused by oncoviruses
  • hepatitis B virus, (HBV) hepatitis C virus (HCV), Epstein Barr Virus (EBV), high-risk Human Papillomaviruses (HPVs), Human T lymphotropic Virus-1 (HTLV-1), HIV and Kaposi’s sarcoma herpesvirus (KSHV)
  • Nathan Goodyear on 18 Dec 17
     
    good review of the oncoviruses: EBV, HBV, HCV, HPV, HTLV-1, HIV, and KSHV.  UP to 12% of cancers are caused by oncoviruses
Nathan Goodyear

Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challengi... - 0 views

www.ncbi.nlm.nih.gov/...PMC497621

EBV Epstein-Barr virus mono

shared by Nathan Goodyear on 15 Dec 16 - No Cached
  • Nathan Goodyear on 15 Dec 16
     
    Good review of lab perspective on EBV.
Nathan Goodyear

Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challengi... - 1 views

www.ncbi.nlm.nih.gov/...PMC497621

EBV virus Epstein-Barr

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Everything you ever wanted to know about EBV.
Nathan Goodyear

Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate pot... - 0 views

onlinelibrary.wiley.com/...pros.22562

cancer virus prostate cancer EBV HPV Epstein-Barr virus human papilloma virus

shared by Nathan Goodyear on 03 Oct 18 - No Cached
  • Nathan Goodyear on 03 Oct 18
     
    Is prostate cancer the result of viral infection.  Study suggests HPV and EBV play a role.
Nathan Goodyear

Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Ca... - 0 views

clincancerres.aacrjournals.org/...4441

EBV Epstein-Barr virus gastric cancer cancer

shared by Nathan Goodyear on 18 Jun 18 - No Cached
  • Nathan Goodyear on 18 Jun 18
     
    EBV gastric cancer found to be associated with the best prognosis.
Nathan Goodyear

Human cytomegalovirus in high grade serous ovarian cancer possible implications for pat... - 0 views

www.ncbi.nlm.nih.gov/...PMC5794372

Cancer "ovarian cancer" CMV cytomegalovirus

shared by Nathan Goodyear on 14 Feb 19 - No Cached
  • Nathan Goodyear on 14 Feb 19
     
    CMV plays role in ovarian cancer. EBV, HPV have shown to play role in other cancers. The likely mechanism is via genetic incorporation of viral genome into the cancer genome.
Nathan Goodyear

How is the Immune System Suppressed by Cancer - 1 views

www.cancertutor.com/ancer-suppresses-immune-system

iNOS cancer immune system

shared by Nathan Goodyear on 23 May 18 - No Cached
  • nitric oxide (NO) released by tumor cells
  • Excellent work by Prof de Groot of Essen, indicated by adding exogenous xanthine oxidase ( XO) in hepatoma cells, hydrogen peroxide was produced to destroy the hepatoma cells
  • NO from eNOS in cancer cells can travel through membranes and over long distances in the body
  • ...43 more annotations...
  • NO also is co linked to VEGF which in turn increases the antiapoptotic gene bcl-2
  • The other important influence of NO is in its inhibition of the proapoptoic caspases cascade. This in turn protects the cells from intracellular preprogrammed death.
  • nitric oxide in immune suppression in relation to oxygen radicals is its inhibitory effect on the binding of leukocytes (PMN) at the endothelial surface
  • Inhibition of inducible Nitric Oxide Synthase (iNOS)
  • NO from the tumor cells actually suppresses the iNOS, and in addition it reduces oxygen radicals to stop the formation of peroxynitrite in these cells. But NO is not the only inhibitor of iNOS in cancer.
  • Spermine and spermidine, from the rate limiting enzyme for DNA synthases, ODC, also inhibit iNOS
  • tolerance in the immune system that decreases the immune response to antigens on the tumors
  • Freund’s adjuvant
  • increase in kinases in these cells which phosphorylate serine, and tyrosine
  • responsible for activation of many growth factors and enzymes
  • phosphorylated amino acids suppress iNOS activity
  • Hexokinase II
  • Prostaglandin E2, released from tumor cells is also an inhibitor of iNOS, as well as suppressing the immune system
  • Th-1 subset of T-cells. These cells are responsible for anti-viral and anti-cancer activities, via their cytokine production including Interleukin-2, (IL-2), and Interleukin-12 which stimulates T-killer cell replication and further activation and release of tumor fighting cytokines.
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      Th1 cells stimulate NK and other tumor fighting macrophages via IL-2 and IL-12; In contrast, Th2, which is stimulated in allergies and parasitic infections, produce IL-4 and IL-10.  IL-4 and IL-10 inhibit TH-1 activation and the histamine released from mast cell degranulation upregulates T suppressor cells to further immune suppression.
  • Th-2 subset of lymphocytes, on the other hand are activated in allergies and parasitic infections to release Interleukin-4 and Interleukin-10
  • These have respectively inhibitory effects on iNOS and lymphocyte Th-1 activation
  • Mast cells contain histamine which when released increases the T suppressor cells, to lower the immune system and also acts directly on many tumor Histamine receptors to stimulate tumor growth
  • Tumor cells release IL-10, and this is thought to be one of the important areas of Th-1 suppression in cancer patients
  • IL-10 is also increased in cancer causing viral diseases such as HIV, HBV, HCV, and EBV
  • IL-10 is also a central regulator of cyclooxygenase-2 expression and prostaglandin production in tumor cells stimulating their angiogenesis and NO production
  • nitric oxide in tumor cells even prevents the activation of caspases responsible for apoptosis
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      NO produced by cancer cells inhibits proapoptotic pathways such as the caspases.
  • early stages of carcinogenesis, which we call tumor promotion, one needs a strong immune system, and fewer oxygen radicals to prevent mutations but still enough to destroy the tumor cells should they develop
  • later stages of cancer development, the oxygen radicals are decreased around the tumors and in the tumor cells themselves, and the entire cancer fighting Th-1 cell replication and movement are suppressed. The results are a decrease in direct toxicity and apoptosis, which is prevented by NO, a suppression of the macrophage and leukocyte toxicity and finally, a suppression of the T-cell induced tumor toxicity
  • cGMP is increased by NO
  • NO in cancer is its ability to increase platelet-tumor cell aggregates, which enhances metastases
  • the greater the malignancies and the greater the metastatic potential of these tumors
  • The greater the NO production in many types of tumors,
  • gynecological
  • elevated lactic acid which neutralizes the toxicity and activity of Lymphocyte immune response and mobility
  • The lactic acid is also feeding fungi around tumors and that leads to elevated histamine which increases T-suppressor cells.  Histamine alone stimulates many tumor cells.
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      The warburg effect in cancer cells results in the increase in local lactic acid production which suppresses lymphocyte activity and toxicity as well as stimulates histamine production with further stimulates tumor cell growth.
  • T-regulatory cells (formerly,T suppressor cells) down regulate the activity of Natural killer cells
  • last but not least, the Lactic acid from tumor cells and acidic diets shifts the lymphocyte activity to reduce its efficacy against cancer cells and pathogens in addition to altering the bacteria of the intestinal tract.
  • intestinal tract bacteria in cancer cells release sterols that suppress the immune system and down regulate anticancer activity from lymphocytes.
  • In addition to the lactic acid, adenosine is also released from tumors. Through IL-10, adenosine and other molecules secreted by regulatory T cells, the CD8+ cells can be inactivated to an anergic state
  • Adenosine up regulates the PD1 receptor in T-1 Lymphocytes and inhibits their activity
  • Adenosine is a purine nucleoside found within the interstitial fluid of solid tumors at concentrations that are able to inhibit cell-mediated immune responses to tumor cells
  • Adenosine appears to up-regulate the PD1 receptor in T-1 Lymphocytes and inhibits the immune system further
  • Mast cells with their release of histamine lower the immune system and also stimulate tumor growth and activate the metalloproteinases involved in angiogenesis and metastases
  • COX 2 inhibitors or all trans-retinoic acid
  • Cimetidine, an antihistamine has been actually shown to increase in apoptosis in MDSC via a separate mechanism than the antihistamine effect
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      cimetidine is an H2 blocker
  • interleukin-8 (IL-8), a chemokine related to invasion and angiogenesis
  • In vitro analyses revealed a striking induction of IL-8 expression in CAFs and LFs by tumor necrosis factor-alpha (TNF-alpha)
  • these data raise the possibility that the majority of CAFs in CLM originate from resident LFs. TNF-alpha-induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target
  • Nathan Goodyear on 23 May 18
     
    Great review of the immunosuppression in cancer driven by the likes of NO.
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