small study finds diet rich in whole grains compared to refined grains improves gut bacteria balance and immune system. Maybe the key to optimal gut health is the diet?
Prospective study finds that gluten free diets for some may limit healthy whole grains, which may increase CVD. This increase was 75 cases per 100 000 persons. However, the study did find that it appears that an elimination of the whole grains likely is the culprit. An elimination of refined processed grains and not whole grains is beneficial. A gluten free diet is not and should not be a dietary fad. If testing reveals gluten free nutrition is required, only then should this be pursued with the additions of certain, whole-grain foods.
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The most abundant lipid constituents are triacylglycerols, free cholesterol, cholesterol esters and
phospholipids (phosphatidylcholine and sphingomyelin especially ), though fat-soluble vitamins and anti-oxidants
are also transported in this way
the lipoprotein aggregates should be described in terms of the different protein components or
apoproteins (or 'apolipoproteins'
Density is determined largely by the relative concentrations of triacylglycerols and proteins
and by the diameters of the broadly spherical particles
these classes can be further refined by improved separation procedures, and intermediate-density lipoproteins
(IDL) and subdivisions of the HDL
(e.g. HDL1, HDL2, HDL3 and so forth
the main groups are classified as chylomicrons (CM), very-low-density lipoproteins
(VLDL), low-density lipoproteins (LDL) and high-density lipoproteins
(HDL), based on the relative densities of the aggregates on ultracentrifugation
the various lipid components should not be considered as absolute,
as they are in a state of constant flux
Apo A1 is the main protein component of HDL
Apo A2 is the second most important HDL apolipoprotein
Lipoproteins are spherical (VLDL, LDL, HDL) to discoidal (nascent HDL) in shape with a core of non-polar lipids,
triacylglycerols and cholesterol esters, and a surface monolayer, ~20Å thick,
consisting of apoproteins, phospholipids and non-esterified cholesterol,
which serves to present a hydrophobic face to the aqueous phase
The lipoproteins can be categorised simplistically according to their two main metabolic functions.
The principal role of the chylomicrons and VLDL is to transport triacylglycerols
‘forward’ as a source of fatty acids from the
intestines or liver to the peripheral tissues. In contrast, the HDL remove excess cholesterol from peripheral tissues and
deliver it to the liver for excretion in bile in the form of
bile acids (‘reverse cholesterol transport’).
While these functions are considered separately here for convenience,
it should be recognised that the processes are highly complex and inter-related, and they involve transfer of apoproteins,
enzymes and lipid constituents among the heterogeneous mix of all the lipoprotein fractions.
High saturated fat and sugar diet causes reduced BDNF in the hippocampus. This is an animal model. The effect was a reduction in spacial learning. Dietary choice can effect the neuroplasticity and learning capacity of the hippocampus.