This study assumes a 13% low T prevalence. Probably too low. This will only grow. Low T contributes to many disease states in men. This study showed a cost of 190-525$ billion in cost from these disease states over a 20 year time period.
Government review of trends of states reporting on Autism incidence/prevalence. The question, is why are not all of the state following this? Especially Louisiana and Mississippi.
Hot flashes reduced with weight loss in those not taking HRT. Reduced fat equals reduced inflammation equals reduced hot flashes/night sweats. The more inflamed an individual, the more prevalent/significant the hot flashes.
Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P < 0.001] and compensated (RRR = 2.41; P < 0.001) hypogonadism. Body mass index of 30 kg/m2 or higher was associated with secondary hypogonadism (RRR = 8.74; P < 0.001)
The prevalence of low T varies significantly between lean versus overweight men. This suggests a significant contribution of obesity and its biologic effects as a cause of low T. The difference is 30%.
Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
as were total testosterone and SHBG in men aged 65–96 years
and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
men with T2DM commonly have low total or free testosterone levels
Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
the recognized association between low SHBG level and insulin resistance
Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
In men aged 73–94 years, total testosterone was inversely correlated with CIMT
a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
Declining Testosterone or low Testosterone is clearly associated with poor health in men.
Very nice review of the association between low Testosterone and metabolic dysfunction. Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
liposomal curcumin at 20 mg/kg reduced pancreatic tumor growth by 42% in in vitro and xenograft studies. The curcumin, the most prevalent polyphenol in tumeric, was given intraperitoneal in this study.
I like this study. So many men, and women for that matter, focus on cardio for health and weight loss. In men, low Testosterone is associated with aging as is weight. This inverse relationship leads to the sarcopenic (belly, manboobs, and thin arms/legs) obesity so prevalent in older men today. This study found that older men do have lower levels of enzymes and androgens from muscle biopsies as compared to younger men. A 12 week resistance training regimen of only knee flexion and extension (simple) resulted in increased 3-beta-hydroxysteroid dehydrogenase and 17-beta-hydroxysteroid dehydrogenase.
Study looked at low T in men with type 1 Diabetes. Only abstract available here. Study finds appx 10% prevalence with age, waist circumference and insulin requirements as predictive of low T in men with type 1 Diabetes.