Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views
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vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
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The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
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The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
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plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
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No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
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A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
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The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
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higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
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A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
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In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
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The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
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animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
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A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
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New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue. Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.