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bipolar androgen therapy proposed as a mechanism to restore AR sensitivity in those men with castration resistant prostate cancer.  This was a very small pilot study.  The effects on PSA were limited in effect as all men eventually developed PSA increase

Stress plays role in BDNF levels.  A decrease in BDNF is found in bipolar patients.  Stress will reduce neuroplasticity through a reduction in BDNF.

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Nutritional therapies for mood disorders.

Omega-3 beneficial in depression and bi-polar clients