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Nathan Goodyear

Vitamin D intake and incidence of multiple scleros... [Neurology. 2004] - PubMed result - 0 views

  • a protective effect of vitamin D intake on risk of developing MS.
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    vitamin D intake protects against risk of MS
Nathan Goodyear

Prevention and management of type 2 diabetes: dietary components and nutritional strate... - 0 views

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    Unfortunately, on the summary is available to public, but review of nutrition for Diabetes points to Mediterranean diet, high vegetable intake, olive oil, and non-red meat intake for protein--particularily beans and legumes.  Compare this to the average counseling for those with Diabetes today.  
Nathan Goodyear

Fish consumption among healthy adults is associated with decreased levels of inflammato... - 0 views

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    Only abstract available here but higher fish intake associated with a decrease in CRP, IL-6, TNF-alpha, amyloid A and WBC; restated, higher fish intake associated with a reduction of inflammation
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

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    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
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  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • adequate plasma levels (i.e., >50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
  • hypovitaminosis C (i.e., <23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
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    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Nathan Goodyear

Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in ... - 0 views

  • Obesity and models of obesity induced by ingestion of HF-diet in rodents are associated with chronically elevated circulating levels of LPS
  • chronic low-dose administration of LPS induces leptin-resistance in vagal afferent neurons and abolition of CCK-induced inhibition of food intake
  • HF fat feeding has been shown to enhance gastrointestinal permeability promoting the translocation of LPS to the circulation
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  • LPS leads to an increase in SOCS3 expression [20]. SOCS3 is a negative regulator of leptin signaling
  • We observed a significant increase in energy intake in the LPS-treated rats
  • the data provides a mechanism linking changes in gut microbiota induced by ingestion of HF diets to dysregulation of food intake and body weight
  • Chronic low-dose LPS treatment induced TLR4 activation and MyD88 signaling in vagal afferent neurons, associated with increased SOCS3 expression and reduced leptin-signaling, characterized by the absence of leptin-induced pSTAT3.
  • SOCS3 is an important mechanism by which leptin resistance develops in vagal afferent neurons and coincides with the onset of hyperphagia
  • We demonstrate that this chronic low dose LPS is sufficient to induce leptin–resistance in vagal afferent neurons, reduced sensitivity to the satiating effects of CCK, and loss of vagal afferent plasticity
  • it suggests that the increase in food intake and body weight we observed at week 6 in the LPS treated rats may be caused by LPS-induced leptin resistance.
  • chronic LPS treatment of mice for four weeks increased body weight
  • chronic LPS treatment of mice for four weeks increased subcutaneous fat
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    Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.
Nathan Goodyear

The monounsaturated fatty acid intake modulates the effect of ADIPOQ polymorphisms on o... - 0 views

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    Epigenetics: the interplay between genetics and the environment.  They influence each other.  This study shows how genetic SNPs influence the impact of lipid metabolism in overweight white people.  The genetic SNPs influenced how the individuals metabolized dietary fat intake.
Nathan Goodyear

Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morph... - 0 views

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    High omega 3 intake associated with improved embryo morphology i.e. likely improved conception and pregnancy rates.
Nathan Goodyear

Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate foo... - 0 views

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    review article of polyphenols positive effect on neuroregulatory factors involved in food intake and energy balance.  Only abstract available here.
Nathan Goodyear

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortal... - 0 views

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    high red meat protein intake associated with higher mortality rate compared to plant-based protein.
Nathan Goodyear

Caffeine Intake and Semen Quality in a Population of 2,554 Young Danish Men - 0 views

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    high coke intake (defined as 1 L or greater) daily associated with lower sperm count and concentration.  
Nathan Goodyear

Access : Urinary DEHP metabolites and fasting time in NHANES : Journal of Exposure Scie... - 0 views

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    urinary DEHP metabolites shown to be good test to evaluate recent dietary intake or exposure
Nathan Goodyear

Central Nervous system control of food intake - 0 views

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    For you biochemistry junkies. A great review of how the Gut and CNS communicate to regulate food intake
Nathan Goodyear

Ghrelin Enhances Appetite and Increases Food Intake in Humans - 0 views

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    ghrelin stimulates appetite and thus food intake.  It also stimulates GH release
Nathan Goodyear

Sugar-Sweetened Beverage Intake and the Risk of Type I and Type II Endometrial Cancer a... - 0 views

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    intake of sugar drinks i.e. coke associated with increased risk of type I endometrial cancer in postmenopausal women.
Nathan Goodyear

Effect of long-term dietary protein intake on g... [Diabetologia. 2000] - PubMed - NCBI - 0 views

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    Long-term high protein intake associated with increased gluconeogenesis.  In the presence of insulin resistance, this will promote weight gain.
Nathan Goodyear

What dietary modification best improves insulin sensitivity and why? - Weickert - 2012 ... - 0 views

  • cereal-fibre intake, under isoenergetic conditions, improves whole-body IR in both short-term and more prolonged studies
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    Great review of macronutrients and insulin resistance.  Caloric reduction plus exercise still the best method to reduce insulin resistance.   Long-term high protein intake increases insulin resistance.
Nathan Goodyear

Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes - 0 views

  • DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the upper gut
  • Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
  • Main sources of soluble DF are fruits and vegetables
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  • n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
  • consumption of insoluble DF increased whole body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
  • Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible DF polysaccharides in the colon
  • increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid homeostasis
  • a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
  • Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
  • soluble DF (i.e., pectin, inulin, and β-glucans)
  • cereal DF (i.e., cellulose and hemicelluloses)
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    Good discussion of dietary fiber intake and Diabetes.  
Nathan Goodyear

Alcohol intake and risk of dementia. [J Am Geriatr Soc. 2004] - PubMed - NCBI - 0 views

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    Moderate wine intake daily associated with a lower risk of Alzheimer's disease in the elderly.  But, only in those without the APOE epsilon-4 allele.
Nathan Goodyear

Reevaluation of the protein requirement in young men with the indicator amino acid oxid... - 0 views

  • the mean and population-safe protein requirements were estimated to be 0.93 and 1.2 g · kg−1 · d
  • diet containing 0.90 g · kg−1 · d−1 was at or above physiologic protein requirements for sedentary men
  • The current EAR recommendation and RDA for protein are 0.66 and 0.80 g · kg−1 · d−1, respectively. We believe that these recommendations are tentative because no long-term studies have suggested that these values would maintain nitrogen balance along with lean body mass, muscle mass, serum protein concentrations, immunity, functional capacity etc
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  • a series of long-term balance studies (67-69) showed that intake of the proposed safe allowance of 0.57 g (70) egg protein resulted in negative nitrogen balance, loss of lean body mass, and deteriorating serum protein and transferase values unless additional energy or nonessential nitrogen was supplied
  • The results of the present study suggest that the current EAR recommendations (0.66 g · kg−1 · d−1) and RDA (0.80 g · kg−1 · d−1) for protein are underestimated at 29% and 33%, respectively
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    study looked at protein requirements in 8 "healthy" men.  This study pointed to 1.2 g/kg/day as an appropriate daily dietary protein intake for healthy men.  This far exceeds levels per RDA.
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