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Nathan Goodyear

The association between hyperandrogenemia and the metabolic syndrome in morbidly obese ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4443598

metabolic syndrome obesity Testosterone PCOS hormone hormones hyperandrogenemia

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • a significant inverse relationship between HA and HDL-cholesterol levels which is in accordance with previous studies of women with PCOS
  • HA was associated with 61 % increased adjusted odds of MetS, and that this association was mainly driven by increased odds of dysglycemia and dyslipidemia
  • the prevalences of MetS, PCOS and HA were high among morbidly obese women <50 years of age
  • ...3 more annotations...
  • Compared to women without HA, those with HA had significantly higher odds of having the MetS, which was mainly explained by the associations between HA and the lipid- and glucose components of the MetS
  • FTI-blood test might add value to the cardiovascular risk assessment of premenopausal women with morbid obesity
  • We calculated the free testosterone index (FTI) using the formula: FTI = 100 x serum testosterone (nmol/L) / sex hormone binding globulin (SHBG, nmol/L)
  • Nathan Goodyear on 04 Jun 15
     
    Another study that finds hyperandrogenism in women is associated with increased Metabolic Syndrome.  This study found obesity was associated with increased hyperandrogegism and Metabolic Syndrome irregardless of PCOS diagnosis or not.
Nathan Goodyear

Prevalence and impact of hyperandrogenemia in 1,21... [Endocrine. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24752393

PCOS polycystic ovarian syndrome LH androgens Testosterone glucose FSH SHBG

shared by Nathan Goodyear on 30 Apr 14 - No Cached
  • Nathan Goodyear on 30 Apr 14
     
    Not a new finding, but study finds that 60% of PCOS women have elevated androgens, male hormones.  The study also found increased LH, increased FSH, decreased SHBG, increased free androgen index, and increased fasting glucose levels.
Nathan Goodyear

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adole... - 0 views

eje-online.org/...1093.long

PCOS polycystic ovarian syndrome CRP inflammation insulin insulin resistance women female hormone hormones androgens Testosterone hyperandrogenism

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • subjects with hyperandrogenemic phenotypes displayed the greatest degree of hyperinsulinemia, β-cell function, and chronic inflammation
  • The rise in serum androgens is accompanied by excess insulin secretion, suggesting that insulin directly stimulates ovarian androgen production
  • The degree of hyperinsulinemia does not seem to be directly correlated with the development of HS
  • ...7 more annotations...
  • higher androgen and insulin levels stimulate hair growth
  • genetic and epigenetic changes may be involved in the pathogenesis of PCOS
  • HA has been identified as an important risk factor for MS and dyslipidemias in premenopausal women and adolescents
  • In our study, HA was found to be an independent risk factor for MS as previously reported by Coviello et al.
  • obesity and HA, and not insulin resistance, are the major determinants of chronic inflammation and risk of atherosclerosis in adolescents with PCOS
  • use of an inflammation marker may help identify high-risk females with PCOS
  • hyperandrogenemic PCOS phenotypes have greatest degree of hyperinsulinemia, insulin resistance, and inflammation
  • Nathan Goodyear on 10 Mar 15
     
    Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).
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