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Nathan Goodyear

Exercise-Induced Responses in Salivary Testosterone, Cortisol, and ... - PubMed - NCBI - 0 views

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    Meta analysis of salivary Testosterone and cortisol finds mixed results.  The results are by no means uniform, but resistance training appears to trend to an increased salivary Testosterone and salivary Testosterone to salivary cortisol ratio.  Cardio trends the opposite.  This fits with prior literature on the types of exercise and hormone results.
Nathan Goodyear

Performance of salivary cortisol in the diagnosis of Cushing's syndrome, adrenal incide... - 0 views

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    Salivary hormone testing again shown to gold standard.  This study looked at salivary cortisol levels in those with Cushing's disease, Cushing's syndrome, and with adrenal incidentaloma.   The results make one scratch their head.  The sensitivity and specificities of salivary cortisol were very high, exceeding at least 94% with most > 96 and 97%.  So, why the opposition?  Ignorance I guess.
Nathan Goodyear

Radioimmunoassay and Tandem Mass Spectrometry Measurement of Bedtime Salivary Cortisol ... - 0 views

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    LC-MS/MS shown to be reliable in salivary cortisol evaluation.  Obese individuals create special challenges with regards to coritsol levels, due to peripheral cortisol to cortisone conversion.   This study points out that saliva should not be used solely in the diagnosis of Cushing's syndrome due to unreferenced norms.   That however, doesn't nullify salivary cortisol.  It requires a look at the references.  for those that are obese and being evaluated for cushing's.  There is no perfect test.  T This study is a little misleading in its conclusion.  Salivary testing is valid, but the reference ranges in the obese with suspected cushing's syndrome needs further evaluation: according to these authors.
Nathan Goodyear

Measuring salivary androgens as a useful tool... [Endokrynol Pol. 2012] - PubMed - NCBI - 0 views

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    Study shows good predictive value, with very high correlation with free serum levels, of salivary androstenedione and salivary Testosterone levels in women with PCOS. This study suggests using salivary androstenedione:salivary testosterone be used in the diagnosis of PCOS.
Nathan Goodyear

Salivary estradiol and progesterone levels in conception and nonconception cycles in wo... - 0 views

  • Salivary measurements of E2 and progesterone can be used as noninvasive methods for assessment of ovarian function. Salivary specimens can be collected at home and brought to the laboratory for analysis, obviating the need for frequent phlebotomy. The sensitivity and precision of the salivary E2 assay make it comparable with assays of serum E2 for assessing changes in hormone levels.
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    salivary estradiol and progesterone used to assess women with infertility
Nathan Goodyear

Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease - 0 views

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    salivary testosterone via immunoassay shown to have sensitivity and specificity to be 100%.  Very reliable method to test for testosterone levels.
Nathan Goodyear

Salivary Cortisol Measurement: A Practical Approach to Assess Pituitary-Adrenal Function - 0 views

  • We conclude that salivary cortisol measurements are an excellent index of plasma free cortisol concentrations
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    this study showed salivary cortisol to be an "excellent" means to evaluate both those with adrenal disease and adrenal dysfunction.  Salivary test is a good tool to evaluate the free active cortisol.
Nathan Goodyear

Utility of Salivary Cortisol Measurements in Cushing's Syndrome and Adrenal Insufficiency - 1 views

  • It is expected that the use of the measurement of salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis.
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    Salivary cortisol testing shown to have sensitivity and specificity that exceeds 90%.  Final Quote: "salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis
Nathan Goodyear

Midnight salivary cortisol for the initial diagnos... [J Clin Endocrinol Metab. 2004] -... - 0 views

  • Measuring midnight salivary cortisol is an easy and noninvasive means of diagnosing hypercortisolism. Its diagnostic accuracy is identical to, if not better than, that of previously described gold standards
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    salivary cortisol testing is "better than, that of previously described gold standards."  This makes salivary cortisol testing the gold standard for assessing cortisol levels
Nathan Goodyear

Evaluation of plasma, salivary, and urinary cortis... [Endocr J. 2010] - PubMed result - 0 views

  • Late-night salivary cortisol measurement is therefore a primary method of choice in the screening of patients suspected of having Cushing's syndrome.
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    "cortisol measurement is therefore a primary method of choice in the screening of patients suspected of having Cushing's syndrome".  This study compared plasma, salivary, and urinary tests.  salivary testing of cortisol is settled. Safe, reliable, and preferred method of evaluation.
Nathan Goodyear

A comparison of the use of urinary c... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

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    night time salivary cortisol found to correlate with early morning urine samples in those with Cushing's.  This in addition to the nocturnal salivary cortisol correlation found in past studies.  The positive studies on salivary cortisol testing continues to build.
Nathan Goodyear

Diagnostic significance of salivary testosterone measurement revisited: using liquid ch... - 0 views

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    salivary testosterone, as measured by LC-MS and ELISA, showed strong correlation with serum free "calculated" testosterone.
Nathan Goodyear

Further evidence for the usefulness of the salivary... [Horm Res. 1986] - PubMed - NCBI - 0 views

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    salivary testosterone found to be reliable in men and women during testosterone therapy.  The salivary testosterone levels correlated with serum.
Nathan Goodyear

Comparison of salivary versus serum testos... [Menopause. 2009 Jul-Aug] - PubMed - NCBI - 0 views

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    this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.
Nathan Goodyear

SALIVARY CORTISOL ASSAYS FOR ASSESSING PITUITARY-ADRENAL RESERVE - PETERS - 2008 - Clin... - 0 views

  • Since salivary cortisol concentrations were shown to reflect the free, biologically active fraction in plasma, salivary assay may, in selected cases, provide results of greater diagnostic significance than plasma total concentrations.
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    salivary cortisol found to be superior to total serum cortisol levels.
Nathan Goodyear

Current Status of Salivary Hormone Analysis - 0 views

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    salivary testing of hormones has proven to be reliable from initial reviews, 1982, to  current studies.  As this study points out, salivary testing has even been shown to be superior to other body fluids.  So, why the lack of use by the clinician?  not due to the research!
Nathan Goodyear

Salivary Cortisol Can Replace Free Serum Cortisol Measurements in Patients With Septic ... - 0 views

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    Salivary cortisol shown to correlate, significantly, with serum free cortisol.  This can be used as an alternative means to evaluate cortisol in those with septic shock, as this study did.  "Salivary cortisol testing is noninvasive, easy to perform, and can be conducted daily".
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 0 views

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    European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.
Nathan Goodyear

The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline - 1 views

  • the diagnostic sensitivity and specificity is said to be excellent (92–100%)
  • Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States
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    Endocrine society clinical  practice guideline's state proves validity of salivary cortisol testing.  Statement: "the diagnostic sensitivity and specificity is said to be excellent (92-100%)" and " Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States"
Nathan Goodyear

ScienceDirect - Clinical Biochemistry : Advantage of salivary cortisol measurements in ... - 1 views

  • nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome
  • Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease
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    salivary cortisol is shown to be reliable for both Addison's and Cushing's Syndrome
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