Skip to main content

Home/ Dr. Goodyear/ Group items tagged gender

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Circulating vitamin D levels are associated with the presence and severity of coronary ... - 0 views

www.ncbi.nlm.nih.gov/...25640800

vitamin D CAD cardiovascular disease coronary artery disease heart disease heart health

shared by Nathan Goodyear on 08 Oct 15 - No Cached
  • Nathan Goodyear on 08 Oct 15
     
    Study finds vitamin D is most significant predictor of CAD > than age, gender (male), hypertension, and hyperlipidemia.  Traditional Dogma is not going to care much for these results.  
Nathan Goodyear

Individual diet has sex-dependent effects on vertebrate gut microbiota : Nature Communi... - 0 views

www.nature.com/...ncomms5500.html

gut flora gut microbiome gut microbiota diet nutrition dysbiosis gut

shared by Nathan Goodyear on 26 Jun 15 - No Cached
  • Nathan Goodyear on 26 Jun 15
     
    Sex difference of gut flora has different metabolic effects from the same diet.  Could it all begin in the get?  Are gut flora sexist?  Of course not, but this study highlights the sex difference of the gut flora and the gender different effects.
Nathan Goodyear

The implication of neuroactive steroids in Tourette syndrome pathogenesis: a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3849218

tourette's syndrome hormones 5-alpha reductase

shared by Nathan Goodyear on 08 Dec 15 - No Cached
  • The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
  • 30–40% of TS-affected children retain their symptoms in adulthood
  • Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
  • ...11 more annotations...
  • female gender may predict greater tic severity in adulthood
  • male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
  • the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
  • TS is diagnosed later in females than males
  • ample evidence supports the involvement of DAergic dysfunctions in TS
  • a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
  • steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
  • Unlike males, tic severity is typically increased after puberty in females
  • 26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
  • biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
  • increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
  • Nathan Goodyear on 08 Dec 15
     
    interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
Nathan Goodyear

Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome - 0 views

www.eje-online.org/...385.abstract

adiponectin metabolic syndrome MetS metabolic syndrome

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    correlation of low adiponectin and metabolic syndrome is higher in women than men.
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Obesity and Gender influence cortisol secretion and metabolism in man - 0 views

jcem.endojournals.org/...1806.full.pdf

obesity obese overweight cortisol cortisone HPA

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    This study reveals the degree of metabolism dysfunction in obesity. This study suggests that cortisol metabolism is increased in obesity, which results in increased HPA activity resulting in increased peripheral cortisol production. The question to be asked: is serum, salivary, and urinary cortisol results revealing the same function of cortisol. The answer is no.
Nathan Goodyear

Early onset of hyperuricaemia and gout following treatment for female to male gender re... - 0 views

rheumatology.oxfordjournals.org/...1840.full

gout sex hormones

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    sex hormones play a role in the gout.  It appears that testosterone therapy increases uric acid levels and estradiol decreases uric acid levels.  Though, I question this based on the use of serum levels and thus inadequate assessment of aromatase activity.  Aromatase activity does not occur in the serum, it occurs in the tissue, thus saliva would be the best tool.
Fitness Dada

Best Lower body workouts for women - Fitness Dada - 0 views

www.fitnessdada.com/...best-lower-body-workouts-women

best lower body workout home workouts for women at

shared by Fitness Dada on 01 Jun 15 - No Cached
  • Fitness Dada on 01 Jun 15
     
    It is a myth that lower body workouts can be performed with the health club's machines. If you really want to reshape or resize the lower body part then you need the gender appropriate and well-framed exercise program that can be done from home.
Nathan Goodyear

Gender Bias in Autoimmunity Is Influenced by Microbiota - 0 views

www.sciencedirect.com/...S1074761313003415

autoimmune disease autoimmune disease Gut gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 26 Jun 15 - No Cached
  • Nathan Goodyear on 26 Jun 15
     
    autoimmune disease sexual preference appears to have Gut origins.
Nathan Goodyear

ScienceDirect - Atherosclerosis : Lipoprotein(a) associated with coronary artery diseas... - 0 views

www.sciencedirect.com/...S0021915000004275

Lp(a) Lipoprotein A CAD cardiovascular disease

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • elevated Lp(a) was associated with a significantly increased risk of CAD in men and women
  • Nathan Goodyear on 03 Aug 11
     
    elevated Lp(a) associated with a significant increased risk of CAD in both men and women
Nathan Goodyear

Loss of androgen receptor expression is not associated with pathological stage, grade, ... - 0 views

onlinelibrary.wiley.com/...abstract

bladder cancer bladder cancer androgen receptor androgen receptors androgen receptor

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.
1 - 12 of 12
Showing 20▼ items per page