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Nathan Goodyear

Measurements of salivary progesterone throughout t... [Fertil Steril. 1990] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...2116329

salivary saliva testing hormones hormone progesterone

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Nathan Goodyear on 22 Nov 10
     
    saliva testing in infertility patients
Nathan Goodyear

Use of clomiphene citrate to reverse premature and... [Fertil Steril. 2003] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...12524089

clomiphene clomid hypogonadism

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • Nathan Goodyear on 28 Apr 11
     
    clomid used to reverse hypogonadism in male with prior anabolic abuse
Nathan Goodyear

Idiopathic hypogonadotropic hypogonadism in a ... [Fertil Steril. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9093212

clomid HPA hypothalmus pituitary low T Testosterone male men hormone hormones endurance exercise athlete

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    Case study finds clomid restores HPA function and normalizes Testosterone production in HPA suppressed endurance athlete.
Nathan Goodyear

Functional Importance of 1α,25(OH)2-Vitamin D3 and the Identification of Its ... - 0 views

www.hindawi.com/...808906

vitamin D Testis testicles Testosterone sperm fertility infertility

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • Nathan Goodyear on 29 Jul 14
     
    Vitamin D plays role in healthy Testes function.  This signaling occurs through genomic and non-genomic signaling pathways.  Testosterone production is influenced, sperm motility and spermatogenesis is influenced.  
Nathan Goodyear

Enclomiphene citrate stimulates testosterone p... [Fertil Steril. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25044085

enclomiphen Testosterone LH FSH men male hormone hormones

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Enclomiphen, a clomid isomer, stimulates FSH and LH to preserve spermatogenesis and Testosterone production.
Nathan Goodyear

Complete reversal of adult-onset isolated hypo... [Fertil Steril. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17070201

clomid hypogonadism low T TEstosteorne men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    study finds restoration of HPA in men with low T.  This was performed via clomid therapy at 25 to 50 mg daily for 4 months.  Increase in pulsatile LH, increase in serum Testosterone levels, and increase in sexual function was found.  Clomid restores HPA function that is suppressed from estrogen inhibition.  In this case, clomid is function as an estrogen antagonist.
Nathan Goodyear

http://medind.nic.in/icb/t06/i8/icbt06i8p711.pdf - 0 views

medind.nic.in/...icbt06i8p711.pdf

Celiac disease hypogonadism low T Testosterone fertility infertility hormone hormones

shared by Nathan Goodyear on 28 Jul 14 - No Cached
  • Nathan Goodyear on 28 Jul 14
     
    Hypogonadism appears to be associated with Celiac disease in men.  Infertility appears to be an association with women.
Nathan Goodyear

http://www.biomedcentral.com/content/pdf/1750-1172-7-11.pdf - 0 views

www.biomedcentral.com/...1750-1172-7-11.pdf

hormone hormones endocrine inborn errors of metabolism metabolism diabetes hypogonadism thyroid fertility

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    endocrine abnormalities associated with inborn errors of metabolism.
Nathan Goodyear

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4114109

statin statin therapy statins sperm men male fertility atorvastatin hormones

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • Nathan Goodyear on 04 Sep 14
     
    I really don't understand the purpose of this study.  Why give "healthy" men with normal lipids atorvastatin???  The study found a reduction in TC and LDL, but also a reduction in sperm number, decreased sperm vitality, increased sperm morphology, decreased prostatic acid pho sphatases, epididymal neutral alpha-glucosidase and L-carnitine levels resulted.  
Nathan Goodyear

A randomized, controlled trial comparing the efficacy and safety of aqueous subcutaneou... - 0 views

humrep.oxfordjournals.org/...humrep.deu194.short

BHRT HRT Progesterone infertility

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Bioidentical progesterone used in IVF.  This is not new, the SQ administration is.  So, physicians cry against BHRT, yet bioidentical progesterone has been used for years in the treatment of infertility.
trungtamnamkhoa

Penis enlargement due to where? Cause And Treatment - 1 views

trungtamnamkhoa.com/n-duong-vat-noi-mun-trang.html

penis pimples white acne male men health healthy cancer Testosterone hormone

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    The body of the white pimples is a common feature of boys entering puberty. Understanding their nature will help you no longer worry. White pimples on the penis and pores, squeezing out with a white core. Do these acne affect fertility? This top concern in many young people will be answered right after.
Nathan Goodyear

Progesterone luteal support after ovulation induction and intrauterine insemination: an... - 0 views

www.ncbi.nlm.nih.gov/...28238492

progesterone hormones infertility fertility

shared by Nathan Goodyear on 13 Mar 17 - No Cached
  • Nathan Goodyear on 13 Mar 17
     
    Progesterone in the luteal phase improves the success of gonadotropins and IUI.
Nathan Goodyear

Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US nati... - 0 views

www.bmj.com/bmj.i6865

thyroid disease thyroid functional hypothyroidism hypothroidism fertility infertility

shared by Nathan Goodyear on 13 Mar 17 - No Cached
  • Nathan Goodyear on 13 Mar 17
     
    Thyroid therapy in women with subclinical hypothyroidism found to have improved pregnancy rates (lower pregnancy loss).
Nathan Goodyear

http://www.fertstert.org/article/S0015-0282(16)62744-9/pdf - 0 views

www.fertstert.org/...pdf

male fertility male reproduction contraception vasectomy

shared by Nathan Goodyear on 04 Aug 17 - No Cached
  • Nathan Goodyear on 04 Aug 17
     
    good review of male reproductive physiology.  
Nathan Goodyear

Thieme E-Journals - Hormone and Metabolic Research / Abstract - 0 views

www.thieme-connect.com/...DOI

selenium pregnancy hormones infertility fertility DHEA hirsutism CRP MDA malondialdehyde inflammation PCOS polycystic ovary syndrome

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    Short study found that Selenium improved pregnancy rate compared to placebo, reduced DHEA, hirsutism, CRP and MDA
Nathan Goodyear

Communication between genomic and non-genomic signaling events coordinate steroid hormo... - 0 views

www.ncbi.nlm.nih.gov/...PMC5864526

genomic signaling cancer hormones non-genomic signaling

shared by Nathan Goodyear on 10 Apr 21 - No Cached
  • steroid hormones typically interact with their cognate receptor in the cytoplasm for AR, glucocorticoid receptor (GR) and PR, but may also bind receptor in the nucleus as appears to often be the case for ERα and ERβ
  • This ligand binding results in a conformational change in the cytoplasmic NRs that leads to the dissociation of HSPs, translocation of the ligand-bound receptor to the nucleus
  • In the nucleus, the ligand-bound receptor dimerizes and then binds to DNA at specific HREs to regulate gene transcription
  • ...25 more annotations...
  • some steroid hormone-induced nuclear events can occur in minutes
  • the genomic effects of steroid hormones take longer, with changes in gene expression occurring on the timescale of hours
  • Classical steroid hormone signaling occurs when hormone binds nuclear receptors (NR) in the cytoplasm, setting off a chain of genomic events that results in, among other changes, dimerization and translocation to the nucleus where the ligand-bound receptor forms a complex with coregulators to modulate gene transcription through direct interactions with a hormone response element (HRE)
  • NRs have been found at the plasma membrane of cells, where they can propagate signal transduction often through kinase pathways
  • Membrane-localized ER, PR and AR have been reported to modulate the activity of MAPK/ERK, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), nitric oxide (NO), PKC, calcium flux and increase inositol triphosphate (IP3) levels to promote cell processes including autophagy, proliferation, apoptosis, survival, differentiation, and vasodilation
  • ERα36, a 36kDa truncated form of ERα that lacks the transcriptional activation domains of the full-length protein. Membrane-localized ERα36 can activate pathways including protein kinase C (PKC) and/or mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) to promote the progression of various cancers
  • G protein-coupled receptor 30 (GPR30), also referred to as G protein-coupled estrogen receptor (GPER), is a membrane-localized receptor that has been observed to respond to estrogen to activate rapid signaling
  • hormone-responsive G protein coupled receptor is Zip9, which androgens can activate
  • GPRC6A is another G protein-coupled membrane receptor that is responsive to androgen
  • androgen-mediated non-genomic signaling through this GPCR can modulate male fertility, hormone secretion and prostate cancer progression
  • non-NR proteins located at the cell surface can bind to steroid hormones and respond by eliciting rapid signaling events
  • Estrogens have been shown to induce rapid (i.e. seconds) calcium flux via membrane-localized ER (mER)
  • ER-calcium dynamics lead to activation of kinase pathways such as MAPK/ERK which can result in cellular effects like migration and proliferation
  • 17β-estradiol (E2) has been reported to promote angiogenesis through the activation of GPER
  • Membrane NRs may also mediate rapid signaling through crosstalk with growth factor receptors (GFR)
  • A similar crosstalk occurs between the receptor tyrosine kinase insulin-related growth factor-1 receptor (IGF-IR) and ERα. Not only does IGF-IR activate ERα, but inhibition of IGF-IR downregulates estrogen-mediated ERα activity, suggesting that IGF-IR is essential for maximal ERα signaling
    • Nathan Goodyear
      Nathan Goodyear on 10 Apr 21
       
      This is a bombshell that shatters the current right brain approach to ER. It completely shatters the concept of eat sugar, whatever you want, with cancer treatment in ER+ or hormonally responsive cancer!
  • Further, ER activates IGF-IR pathways including MAPK
  • GPER is involved in the transactivation of the EGFR independent of classical ER
  • tight interconnection between genomic and non-genomic effects of NRs.
  • non-genomic pathways can also lead to genomic effects
  • androgen-bound AR associates with the kinase Src at the plasma membrane, activating Src which then leads to a signaling cascade through MAPK/ERK
  • However, Src can also increase the expression of AR target genes by the ligand-independent transactivation of AR
  • extranuclear steroid hormone actions can potentially reprogram nuclear NR events
  • estrogen modulated the expression of several genes including endothelial nitric oxide synthase (eNOS) via rapid signaling pathways
  • epigenetic changes can then mediate genomic events in uterine tissue and breast cancer cells
harshitatyagi

What is the Procedure of IVF with Donor Embryos... - 0 views

sco.lt/78SP6e

IVF IVF Treatment In Vitro Fertilization IVF Process IVF Pregnancy IVF Babies

shared by harshitatyagi on 27 Sep 22 - No Cached
  • harshitatyagi on 27 Sep 22
     
    The embryo is the combined form of a matured egg and sperm. It is generally known as the most critical stage of IVF treatment. Despite that, successful embryo implantation only decides the achievement of pregnancy, and when it fails, it obstructs the entire IVF process. It extensively occurs when a couple fails to develop a healthy embryo using their eggs and sperm because of poor health conditions.
harshitatyagi

When should IVF be done? - 0 views

www.quora.com/...Geetanjali-Kapoor-31

IVF Treatment Infertility Treatment IVF Process Secondary Infertility In Vitro Fertilization

shared by harshitatyagi on 09 Nov 22 - No Cached
  • harshitatyagi on 09 Nov 22
     
    The most generic question that interrupts every couple's mind is when the IVF process should be done. Is it done when one fails to conceive, or is it done when one suffers from secondary infertility.
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