Salivary progesterone profiles derived from daily sampling of 20 infertile patients not only allowed accurate assessment of ovarian dysfunction but also indicated more effectively than conventional techniques the change in hormonal status following ovulation induction therapy with clomiphene citrate or bromocriptine.
Small study found that 2 months of clomid therapy increased LH, FSH, total Testosterone, and free Testosterone over placebo. Improvement in ED was minimal and most in young men. This is consistent with other studies that have found that less effects are seen in those with multiple comorbidities.
small cohort with low serum Total Testosterone improved T:E2 ratio with clomid. Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men. This allows for an increase in gonadotropin production and thus increase in testosterone production. Aromatase inhibition therapy would likely still prove beneficial in this situation.
Nice study that looked at climid to restore HPA function and increase Testosterone stimulation and production. This study also does a good job of reviewing the mechanisms of low T. Low T is really a biomarker of poor health in men.